In one aspect, the disclosure relates to methods and compositions, i.e., pharmaceutical formulations, for treating and preventing diabetic foot ulcers. In a particular aspect, the disclosed methods and compositions pertain to water-based pharmaceutical formulations that are useful for administration in an aqueous foot bath. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

A treatment system for debriding a treatment area of a tissue site and applying negative pressure is disclosed. In some embodiments, the treatment system may include an ultrasonic bubble generator fluidly coupled to a negative-pressure source, fluid source, and a dressing. Fluid may be drawn from the fluid source to the ultrasonic bubble generator, whereby micro-bubbles and ultrasonic waves may be generated in the fluid before the fluid is instilled to the dressing.

A hysteroscopic fluid management system includes a saline source with an electrolyte concentration, at least one pressure mechanism for circulating saline to and from a targeted site and through a filter having filter characteristics back to the source, and a controller. The controller provides a saline inflow in a first flow path to the site and a saline outflow in a second flow path from the site through the filter and back to the source at a controlled flow rate. A diagnostic or therapeutic procedure is performed at the site in the presence of the saline. The filter characteristics and the controlled flow rate are selected to (1) cause substantially no change in the electrolyte concentration in the saline, (2) to prevent hemolysis of greater than 5% of filtered red blood cells exposed to the saline, and/or (3) to minimize effect on prothrombin time of plasma exposed to the filter.

A device and a method for a lavage-type introduction of a stool transplant or of another, local or topically effective substance through the anus into the colon of a patient, wherein the substance to be introduced is flushed also into the upper parts of the colon of the patient in a torrent-like manner through correspondingly large-lumen catheters; said device comprises an ano-rectal placed head part remaining inside the patient from the beginning until the end of the application and a system of exchangeable bags, which are connectable to the head part, whereby two different types of bags can be applied, one of which is designed for the cleaning lavage, while the another is designed for the introduction of a substance or a transplant.

An apparatus and method use a catheter for specific and discriminate treatment of central nervous system disease. With the catheter, selective hypothermia to the brain and/or the spinal cord for injury protection can be achieved without the need for systemic cooling. The catheter is also capable of draining excess cerebrospinal fluid.

A wound irrigation system and method of making and using. The system uses a pored, closed-ended delivery conduit to enhance the consistency and speed with which anti-microbial or related irrigation fluids may be delivered in order to promote cleansing, debridement and biofilm reduction in wounds. The ease of use of the system as a moist wound healing cascade makes it applicable to both in-home and in-facility environments that is not offered through traditional instillation negative pressure systems. In one form, the fluid delivery conduit is used as part of a dual-conduit approach in order to also help promote the removal of drainage, waste, irrigation overflow or other fluid from the wound. Utilization of such a pored, closed-ended delivery conduit in conjunction with a separate drainage conduit infusing helps reduce the frequency of dressing changes as well as the likelihood of microorganism formation and colonization.

The apparatus pre-treats fluid and then delivers it to a patient during surgery, for example a hyperthermic intra-peritoneal chemotherapy (HIPEC) procedure. It comprises a reservoir (2) for the fluid, a reversible pump (10) and a valve assembly (22). In a recirculation mode, the pump (10) is operated in one direction to draw fluid from the reservoir (2), through the valve assembly (22) and back to the reservoir (2), while the fluid is pre-treated by heating, for example. In a fluid delivery mode, the pump (10) is operated in an opposite direction to draw fluid from the reservoir (2) and deliver the fluid through the valve assembly (22) to a port (30) from which it can be supplied to the patient. A second pump (12) may be provided for drawing fluid from the patient via a return port (48). The pumps (10,12) may be peristaltic pumps integrated with the walls of the reservoir (2).

A hysteroscopic fluid management system includes a saline source with an electrolyte concentration, at least one pressure mechanism for circulating saline to and from a targeted site and through a filter having filter characteristics back to the source, and a controller. The controller provides a saline inflow in a first flow path to the site and a saline outflow in a second flow path from the site through the filter and back to the source at a controlled flow rate. A diagnostic or therapeutic procedure is performed at the site in the presence of the saline. The filter characteristics and the controlled flow rate are selected to (1) cause substantially no change in the electrolyte concentration in the saline, (2) to prevent hemolysis of greater than 5% of filtered red blood cells exposed to the saline, and/or (3) to minimize effect on prothrombin time of plasma exposed to the filter.

A peristaltic pump includes a first motor shaft, a second motor shaft, a first pump head, a second pump head, and a motor. The first pump head is operably coupled to the first motor shaft such that the first pump head is rotated in response to rotation of the first motor shaft. The second pump head is operably coupled to the second motor shaft such that the second pump head is rotated in response to rotation of the second motor shaft. The motor is configured to rotate the first and second motor shafts. The pump head has a first mode in which the first pump head is rotated and the second pump head is idle and a second mode in which the first pump head is idle and the second pump head is rotated.

A peristaltic pump includes a first motor shaft, a second motor shaft, a first pump head, a second pump head, and a motor. The first pump head is operably coupled to the first motor shaft such that the first pump head is rotated in response to rotation of the first motor shaft. The second pump head is operably coupled to the second motor shaft such that the second pump head is rotated in response to rotation of the second motor shaft. The motor is configured to rotate the first and second motor shafts. The pump head has a first mode in which the first pump head is rotated and the second pump head is idle and a second mode in which the first pump head is idle and the second pump head is rotated.