Disclosed is a functional drug injection module including: an injection unit including a body that is elongated, keeps a functional drug therein, has an outlet formed at a front end thereof, and is open at a rear end thereof, and a piston that is inserted in the body through the rear end of the body and discharges the functional drug by longitudinally sliding; a cover unit at least partially formed like a projection, inserted in the outlet, and adjust opening/closing of the outlet by selectively separating; and a sealing unit surrounding the injection unit and the cover unit, having a first crease formed in a longitudinal direction of the injection unit, and separating from the injection unit together with the cover unit by being divided along the first crease by external force.

A knitted stent and a knitted stent system are disclosed, the knitted stent system comprising the knitted stent, a knitted stent (100) is formed by spirally coiling a knitted wire about an axis in an interlaced manner. The knitted wire includes at least one elastic metal tube (110), each elastic metal tube (110) defining a first lumen and having a wall in which release holes (111) in communication with the first lumen are formed. The first lumen can serve as a drug receptacle. A drug can be filled in the receptacle and released from the release holes (111). In this way, the knitted stent (100) can be used as a base of a drug-loaded stent, thus solving the problem of poor geometric compliance and fatigue resistance arising from the use of conventional drug-loaded stents.

A device for insertion into a cavity, such as the vagina of a mammal, the device comprising a body for insertion into the cavity comprising a variable geometry retention mechanism, one or more active-impregnated matrices supported by the body, the matrix or matrices having (i) a ratio of exposed surface area to volume of 11.5:1 to 18.5:1, or (ii) a ratio of exposed surface area to weight of 11:1 to 17:1, or (iii) both (i) and (ii).

Disclosed herein are advantageous drug delivery assemblies, and related methods of fabrication and use thereof. The present disclosure provides improved drug delivery assemblies for extended drug delivery (e.g., via passive diffusion) and/or tunability, and improved systems/methods for utilizing and fabricating the drug delivery assemblies. More particularly, the present disclosure provides single or dual compartment, and dual porous membrane based (e.g., porous zinc membrane based) drug delivery assemblies for extended drug delivery (e.g., via passive diffusion) and/or tunability. The present disclosure also provides for a method for utilizing a drug delivery assembly. The assemblies can be utilized for the extended drug delivery of pharmaceuticals or the like, such as biologics, for the sustained release of medication for greater than six months to overcome difficulties with daily dosing regimes.

The present disclosure is in the field of gastric resident systems. A device for extended retention in a stomach is provided. The device includes: first, second, and third arms, the second and third arms being pivotally connected to respective ends of the first arm. The device is configured to transform between a compressed configuration and an expanded configuration. The device further includes a biasing member configured to bias the device into the expanded configuration whereby the second and third arms are configured to mechanically engage each other to retain the system in the expanded configuration.

Methods and compositions for delivering medicine and other substances to the brain and the body via the cribriform plate using foamable compositions are described. Methods and compositions for improving nasal hygiene and moisturizing the nasal cavity using foamable compositions are also described.

Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the article includes dimensions configured for transesophageal retrieval. In some cases, the articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an immunomodulator.

A miniature device configured to be maneuvered within a patient under manipulation by an external magnetic field and to selectively perform a predefined function is provided. The miniature device comprises a shell defining therewithin an internal cavity, and a magnetic arrangement disposed within the cavity. The miniature device is configured such that the magnetic arrangement, within a rotating magnetic field, effects one of performance of the function and propulsion of the miniature device within the patient, and, within a magnetic field gradient, effects the other of performance of the function and propulsion of the miniature device within the patient.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.