A dynamic gas-flow wound dressing assembly and method for enhancing the effect of generated gas flow across a wound creates spacing between a medical dressing cover and the wound to enhance ventilation. The assembly provides a medical dressing cover that covers a wound. The medical dressing couples to a gas flow framing structure having a gas inlet and enclosed gas outlets. A high rate gas flow is introduced through gas flow framing structure. The gas discharges to cross the wound. A scaffolding partition member serves as a resilient spacer between the gas flow framing structure and wound, enhancing ventilation by forces on the skin and directing gas flow. The scaffolding includes intake ports and outlet ports in fluid communication with inlets and outlets of gas flow framing structure. The scaffolding carries generated gas flow from the gas flow framing structure to wound, covering a larger gas flow volume across wound.

This disclosure describes devices, systems, and methods related to oxygenated hemoglobin, the generation thereof, and the use thereof. An exemplary oxygenated hemoglobin therapy system includes an oxygen source configured to provide oxygen and a hemoglobin source configured to provide topical hemoglobin. The therapy system may also include a mixer which has a first inlet, a second inlet, and an outlet. The mixer is configured to mix the oxygen and the topical hemoglobin to form a mixture and to provide the mixture to a dressing via the outlet. The therapy system may further include the dressing. The oxygenated hemoglobin therapy systems described herein are suitable for use in medical devices, such as bandages, drapes, dressings, and wound closures.

A wound care device for delivering topical oxygen therapy, negative pressure wound therapy, and a low intensity vacuum therapy for treatment of a wound. The wound care device may include an oxygen supply MEA, an oxygen consuming MEA, a vacuum pump and motor, a pressure sensor, and a power supply and electronic controls. A dressing may be connected to the wound care device for administering topical continuous oxygen therapy and simultaneous negative pressure wound therapy to a wound. A canister or exudate trap may be positioned between the dressing and the vacuum supply port of the vacuum pump to collect and store exudates from the wound. The canister may be combined with the dressing.

Systems include a receiving port configured to receive a cartridge configured to store a material capable of being aerosolized, a sensor configured to generate one or more measurements based on ambient conditions of a housing, an aerosolizer configured to aerosolize the material in response to receiving a signal, and a controller comprising one or more processors configured to generate the signal provided to the aerosolizer, and further configured to control operation of the aerosolizer via the signal.

A medical gauze and gas flow assembly and method of applying a medical gauze with gas flow over a wound, provides a medical dressing cover that couples to a gas flow framing structure. The gas flow framing structure provides a flow of gas over a wound. A medical grade gauze material adheres to the lower surface of the medical dressing cover, so as to create spacing between the medical grade gauze material and the wound treatment area. The gas flow is directed between the medical grade gauze material and the wound treatment area. The gas flow vents to ambient though the gas permeable medical dressing cover. When degraded, the assembly is replaced or only the medical dressing cover and medical grade gauze material is replaced. The synergistic combination of a medical grade gauze material that is a gas permeable, with a gas flow structure that discharges gas over the wound enhances healing the wound.

A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.

Multistage vaporizers, such as for use in medical treatment systems, as well as related methods are described. In one example, a multistage vaporizer includes a first reservoir configured to hold a liquid and one or more pumping transducers positioned in the first reservoir. The multistage vaporizer also includes a second reservoir and one or more vaporizing transducers positioned in the second reservoir. The one or more pumping transducers positioned in the first reservoir are configured to generate and move droplets of a liquid in the first reservoir to the second reservoir, and the one or more vaporizing transducers positioned in the second reservoir are configured to create a vapor of the liquid in the second reservoir.

An apparatus for use in applying a therapy to a human limb includes a bag for surrounding all or part of the limb. The apparatus also includes a connection arrangement, mounted to a wall of the bag in a distal portion of the bag, that enables therethrough a flow of a gas between a pressure-regulating device and an interior space of the bag. The apparatus also includes a gas-permeable strip affixed to an interior surface of the bag and having a length equal to at least 70% of the bag's length. The distal end of the strip is in communication with the connection arrangement in the distal portion of the bag, and a proximal end of the strip is disposed in a proximal portion of the bag. The strip contains a partially compressible, gas-permeable material forming a lengthwise gas-flow pathway.

A system for delivery of gas to a tissue, comprises: a first container containing the gas, an applicator having a distal end arranged to deliver the gas to the tissue, a second container containing a purging gas; and a flow control system for controlling flow of gas. The system also comprises a three-port valve having a first port for receiving the gas from the first container, a second port for receiving the purging gas from the second container, and a third port in fluid communication with the applicator. The valve is switchable between a first state at which the first port fluidly connects to the third port, and a second state at which the second port fluidly connects to the third port.

Embodiments of the present disclosure provide systems and devices for delivering gaseous Nitric Oxide (gNO) under therapeutic parameters to reduce infection in a subject. Certain embodiments include devices and systems for delivering pressurized gNO to reduce bioburden and promote healing in the wounds of subjects having various disease conditions, including skin and soft tissue infections (SSTIs) and osteomyelitis. In some embodiments, the present disclosure provides portable wound healing devices for delivering pressurized gNO to the site of a wound to treat various disease conditions in a subject. Other embodiments relate to systems and devices for delivering and for monitoring gaseous Nitric Oxide (gNO) under therapeutic parameters of use to treat a subject. In certain embodiment, the devices include a subject interface unit comprising sensors for detecting gNO pressure and/or gNO flow.