Disclosed herein are advantageous drug delivery assemblies, and related methods of fabrication and use thereof. The present disclosure provides improved drug delivery assemblies for extended drug delivery (e.g., via passive diffusion) and/or tunability, and improved systems/methods for utilizing and fabricating the drug delivery assemblies. More particularly, the present disclosure provides single or dual compartment, and dual porous membrane based (e.g., porous zinc membrane based) drug delivery assemblies for extended drug delivery (e.g., via passive diffusion) and/or tunability. The present disclosure also provides for a method for utilizing a drug delivery assembly. The assemblies can be utilized for the extended drug delivery of pharmaceuticals or the like, such as biologics, for the sustained release of medication for greater than six months to overcome difficulties with daily dosing regimes.

A fluid-management system for selectively draining fluid from a body cavity includes a valve assembly and a tube for carrying fluid from a body cavity of a person to the valve assembly. The valve assembly is configured to be positioned external to the person's body and comprises (i) an inlet, (ii) an outlet, (iii) one or more one-way valves positioned between the inlet and outlet that are each configured to open and close based on fluctuations in pressure between the person's body cavity and the one-way valve, and (iv) an adjustable outlet lock configured to selectively prevent fluid movement through the outlet.

A chest valve including: a housing including an inlet configured to connect to a chest tube, an outlet and a fluid passage from the inlet to the outlet; and a one-way valve within the housing and included in the flow passage, wherein the one-way valve includes: (i) a first tubular strip wherein having an internal air passage and a first layer defining the air passage, wherein the first layer has a first thickness and the internal air passage of the first tubular strip is included in fluid passage of the housing; and (ii) a second tubular strip wherein having a second layer with a second thickness with a second thickness greater than the first thickness, wherein an outer surface of the second tubular strip is adjacent and overlaps an outer surface of the first tubular strip.

Disclosed is a drug injection device that is fixedly implanted a patient's skull and scalp to inject a drug. The disclosed drug injection device includes a main body that is fixedly implanted in contact with a skull and has an internal hole; a main body fixing part that has an internal hole to be adjacent to the main body and is fixedly coupled to the main body; a movable part that is positioned between the main body and the main body fixing part, has a drug injection hole at a central part thereof, and is able to change its direction to a target point; a sealing part that is configured to seal the drug injection hole of the movable part, into which an injection needle for injecting a drug is inserted; a movable lid part that is positioned above the sealing part to close and fix the movable part, prevents the sealing part from being separated and escaping outside, and identifies an implantation position of the drug injection device to guide a point for repeated administration; and at least two fastening members that fasten an upper part of the main body and an upper part of the main body fixing part to the skull, in which the main body includes a support part that is positioned above the skull for support, an outer diameter of the support part is smaller than an outer diameter of the main body fixing part and is greater than an outer diameter of the movable part, and the main body and the main body fixing part are adjacently coupled to each other to accommodate and fix the movable part in the internal hole of the main body.

An implantable medical instrument for use within a body includes a container that has an opening and holds a medicinal solution, and a soft portion that closes the opening. The medical instrument further includes a power receiver that receives power transmitted externally, and a light emitter that emits light by way of the power received by the power receiver. The light emitter includes at least one of a first light emitter that emits light having a center wavelength of 600 nm or more and 1100 nm or less, and a second light emitter that emits light having a center wavelength of 400 nm or more and 480 nm or less.

Disclosed are introducer components, assemblies, and methods. For example, an introducer assembly can include a fluidly connected syringe and needle. The needle can include a needle shaft and a needle hub over a proximal portion of the needle shaft. The needle hub can include a port and a valve disposed in the port. The port can be in a side of the needle hub proximal of a proximal end of the needle shaft. The valve can be configured to form a fluid-tight seal around an elongate medical device such as an access guidewire when passed through the port and into a needle-hub lumen of the needle hub. Such an access guidewire can be disposed in the introducer assembly just proximal of a needle tip of the needle. In this way, the access guidewire can be immediately advanced into a blood-vessel lumen upon establishing a needle tract thereto with the needle.

A valve device suitable for detachably fixing to an access port and includes a fixation clip which has at least a first and second fixation member each of which have one or more rims each having a surface which veers in a direction towards the valve device. There is further provided a removing tool for removing the valve device from an access port. There is further provided a mounting tool for mounting a valve device in an access port. An assembly having a mounting tool and a valve device is also provided.

A surgical port includes a first end, a second end opposite the first end, and a longitudinal axis extending through the first end and the second end. An outer sidewall extends between the first end and the second end. First and second channels extend through the port from the first end to the second end. A first electrically conductive portion extends from the first channel to the outer sidewall, and a second electrically conductive portion extends from the second channel to the outer sidewall. The first electrically conductive portion provides a first electrically conductive path between the first channel and the outer sidewall and the second electrically conductive portion provides a second electrically conductive path the second channel and the outer sidewall. The second electrically conductive path is separate from the first electrically conductive path. Devices and methods relate to surgical ports.

Apparatus and methods for controlled arterial/venous access are provided. The apparatus and methods may include a section of tubing anastomosed to a bodily lumen. A lumen clamping means may utilize a clamp manipulator to effectively seal the tubing, and the manipulator may be operated by two fingers. A needle receptor may be utilized, and the receptor may utilize a rotating member to guide a needle inserted from outside the body, in order ensure accurate placement into a channel. The channel may be in liquid communication with the tubing. The manipulator and the needle receptor may be palpable from outside the body.

A chest drainage system securing apparatus for securing and maintaining chest drainage systems in position following placement into a human or animal patient and preventing movement or unplanned removal thereof in response to the application of significant forces in any direction thereto, be they longitudinal, torsional/rotational or bending. The securement system includes retention devices secured to a chest tube which interact with an adhesive pad releasably attached to a patient to ensure proper positioning of the chest tube. The adhesive pad includes one or more Heimlich-type valves for sealing sucking chest wounds and for sealing an incision formed in a patients skin and chest for the placement and insertion of a chest tube.