A male connector (100) includes a first fitting structure (127) on an inner circumferential surface of a hood (120) surrounding a male member (110). A female connector (200) includes a rotating cylinder (250) rotatably provided on a female connector main body (210) that includes a partition member (220) made of an elastic material. A second fitting structure (257) is provided on an outer circumferential surface of the rotating cylinder. When the male connector is connected to the female connector, the male member passes through a slit (223) of the partition member, the female connector is inserted into the hood, and the first fitting structure fits to the second fitting structure.

A male connector (100) includes a first fitting structure (127) on an inner circumferential surface of a hood (120) surrounding a male member (110). A female connector (200) includes a rotating cylinder (250) rotatably provided on a female connector main body (210) that includes a partition member (220) made of an elastic material. A second fitting structure (257) is provided on an outer circumferential surface of the rotating cylinder. When the male connector is connected to the female connector, the male member passes through a slit (223) of the partition member, the female connector is inserted into the hood, and the first fitting structure fits to the second fitting structure.

An instrument having a dosing unit connected to a handle or housing of instrument. The dosing unit may include a reusable actuator with a drive unit and a single-use cartridge. The Cartridge may have a cylinder and a piston, and may be filled by a user prior to the intervention or may be prefilled by the manufacturer. The dosing unit is brought into an open position offset from housing by, for example, operating a latch slider and pulling the dosing unit in a proximal direction. After insertion of the cartridge, the dosing unit may be moved toward housing and the latched slider will lock the dosing unit into a closed position.

An instrument having a dosing unit connected to a handle or housing of instrument. The dosing unit may include a reusable actuator with a drive unit and a single-use cartridge. The Cartridge may have a cylinder and a piston, and may be filled by a user prior to the intervention or may be prefilled by the manufacturer. The dosing unit is brought into an open position offset from housing by, for example, operating a latch slider and pulling the dosing unit in a proximal direction. After insertion of the cartridge, the dosing unit may be moved toward housing and the latched slider will lock the dosing unit into a closed position.

An adapter for connecting a first connector to a second connector can include a proximal portion configured to linearly engage the first connector with a snap-fit engagement. The adapter can include a distal portion configured to rotationally engage the second connector. Rotation of the adapter relative to the second connector can advance a male luer of the first connector into substantially sealing engagement with a female luer on the second connector. The adapter can be configured to displace a collar on the first connector when coupled to the first connector. The second connector can include a proximal portion that is configured to engage the first connector, such as with a snap-fit engagement.

A valve assembly including a housing having a base and an outer shell, which forms a proximal cavity and a distal cavity joined by a canal; an inner housing configured for longitudinal movement within the distal cavity; a seal positioned within the distal cavity that together with the longitudinal movement of the inner housing regulates the flow of fluid through the valve assembly; and one or more selected from the group consisting of the base notched with one or more notches and the inner housing having one or more through slots aligned to permit access to the one or more notches, the seal being a reversibly deformable sealing pin, and a torque limiter mechanism configured to resist the longitudinal movement of the inner housing distally until a sufficient radial force is applied.

Couplers are described herein. A coupler includes a coupler body, a plurality of first retaining fingers, and a plurality of second retaining fingers. The coupler body includes a first end and a second end, and defining a cavity, the cavity configured to receive a first connector and a second connector. The plurality of first retaining fingers are configured to engage against a collar of the first connector to prevent axial motion of the first connector relative to the coupler. The plurality of second retaining fingers are configured to engage against a shoulder of the second connector with a retention force, and release the second connector by radially expanding in response to a pullout force exerted on the second connector exceeding the retention force.

A connector set includes a male connector; and a female connector. The male connector includes: a hollow rod-shaped flow path connection portion that defines a first flow path therein and that has a first axis as a center, and a lock protrusion that has an inner peripheral edge extending in a circumferential direction around the first axis. The female connector includes: a cap, a housing, and a valve body. The cap includes: a top wall, and a cylindrical outer peripheral wall extending from an outer peripheral edge of the top wall and that has a second axis as a center. The housing includes: a cylindrical wall, and an engagement protrusion protruding from an outer peripheral surface of the cylindrical wall so as to form a lower surface configured to engage with the lock protrusion to lock the male connector.

A connector set includes a male connector; and a female connector. The male connector includes: a hollow rod-shaped flow path connection portion that defines a first flow path therein and that has a first axis as a center, and a lock protrusion that has an inner peripheral edge extending in a circumferential direction around the first axis. The female connector includes: a cap, a housing, and a valve body. The cap includes: a top wall, and a cylindrical outer peripheral wall extending from an outer peripheral edge of the top wall and that has a second axis as a center. The housing includes: a cylindrical wall, and an engagement protrusion protruding from an outer peripheral surface of the cylindrical wall so as to form a lower surface configured to engage with the lock protrusion to lock the male connector.

Some fluid coupling devices described herein are configured for use in fluid systems for purposes of providing a single-use, aseptic disconnection functionality that substantially prevents fluid spillage when being disconnected. In some embodiments, the coupling portions cannot be reconnected to each other after being disconnected from each other.