A pump device includes a pump driver comprising a first diaphragm and a second diaphragm, the first and second diaphragms each comprising a middle portion bounded by an outer portion, the first and second diaphragms being spatially separated from each other at the respective outer portions, and coupled together at the respective middle portions. The pump also includes a fluid passageway and a pump chamber fluidly connected to the fluid passageway, wherein the pump chamber comprises a moveable wall coupled to the pump driver at the middle portions of the first and second diaphragms such that a fluid movement between the pump chamber and the fluid passageway is induced by movement of the middle portions. An input device is configured to obtain a target flow rate. A controller is configured to operate the pump driver and a flow regulator based on signals received from a flow detector.

A wearable infusion pump assembly. The wearable infusion pump assembly includes a reservoir for receiving an infusible fluid and a fluid delivery system configured to deliver the infusible fluid from the reservoir to an external infusion set. The fluid delivery system includes a controller, a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the external infusion set, the pump assembly comprising a pump plunger, the pump plunger having distance of travel, the distance of travel having a starting position and an ending position, at least one optical sensor assembly for sensing the starting position and ending position of the pump plunger distance of travel and sending sensor output to the controller, and a first valve assembly configured to selectively isolate the pump assembly from the reservoir, wherein the controller receives the sensor output and determines the total displacement of the pump plunger.

Various exemplary methods, systems, and devices for injection pump needle mechanics are provided.

A wearable infusion pump assembly. The wearable infusion pump assembly includes a reservoir for receiving an infusible fluid and a fluid delivery system configured to deliver the infusible fluid from the reservoir to an external infusion set. The fluid delivery system includes a controller, a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the external infusion set, the pump assembly comprising a pump plunger, the pump plunger having distance of travel, the distance of travel having a starting position and an ending position, at least one optical sensor assembly for sensing the starting position and ending position of the pump plunger distance of travel and sending sensor output to the controller, and a first valve assembly configured to selectively isolate the pump assembly from the reservoir, wherein the controller receives the sensor output and determines the total displacement of the pump plunger.

Various exemplary liquid drug pumps with a flexible drug reservoir are provided. In general, a pump includes a flexible reservoir configured to contain a liquid drug therein for delivery to a patient wearing the pump. The reservoir is configured to be filled with the drug from a drug storage container, which can either be external to the pump or disposed within the pump.

The present disclosure relates to a medical pump for dispensing a liquid. The medical pump includes a housing, a receptacle and a piston. The housing includes an inlet for receiving said liquid and an outlet for dispensing said liquid. The receptacle includes a chamber and a passage that is in fluid communication with the chamber. The receptacle is received in the housing and is axially movable relative to the housing from a filling position, wherein the passage fluidly communicates the chamber with the inlet, to a dispensing position, wherein the passage fluidly communicates the chamber with the outlet. The piston is received in the chamber and is configured such that when the receptacle is in the filling position the piston is axially moveable relative to the receptacle and when the receptacle is in the dispensing position the piston is axially moveable relative to the receptacle.

A substance delivery device engages with a reservoir, and includes a pump that draws therapeutic substance from the reservoir into a pump chamber of the delivery device without changing the internal dimensions of the reservoir. The volume of the therapeutic substance within the pump chamber varies in response to changes in the internal dimensions of the pump chamber. An orientation sensor generates an output indicating an orientation of the delivery device with respect to gravity. Control circuitry drives the pump to: calculate a volume of the substance within the reservoir, draw the substance into the pump chamber in response to (i) the calculated volume, in combination with (ii) an output from the orientation sensor that the delivery device is in an orientation that allows the substance to be drawn from the reservoir, and deliver the substance from the pump chamber to the subject. Other applications are also described.

An improved device delivers a fluid medicament to the subcutaneous tissue of a user. The device is better suited for patients with Parkinson's Disease and other central nervous system disorders, than conventional infusion devices. The device can include a reusable part including a drive component (e.g., motor) and control electronics and a disposable part including a medicament reservoir. Medicament can be evacuated from the medicament reservoir by a plunger assembly that includes a plunger attached to a lead screw that is rotated by a nut, all within the disposable part. The device can be fluidically coupled with the tissue via a flexible cannula. Various embodiments relate to an improved cannula insertion mechanism that delivers the cannula under a force applied by a spring. Various embodiments relate to improved filling of the device, for example, using a vial adapter and an automated filling station.

An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and pivotally movable about a pivot pin relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are pivotally movable about the pivot pin in a radially inward direction to engage with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.

A method of dispensing a therapeutic fluid from a line includes providing an inlet line connectable to an upstream fluid source. The inlet line is in downstream fluid communication with a pumping chamber. The pumping chamber has a pump outlet. The method also includes actuating a force application assembly so as to restrict retrograde flow of fluid through the inlet while pressurizing the pumping chamber to urge flow through the pump outlet. A corresponding system employs the method.