A manually operated mechanical pump for drug infusion through a syringe including a plunger slidable within a syringe body to cause drug contained within the syringe body to exit a front opening of the syringe. The pump has a pump body with an open front end, to which the syringe attaches, and an open rear end, at which a drive member is associated movably relative to the pump body. A pair of thrust members are provided between the drive member and the syringe to impart longitudinal thrust in a distal direction onto the plunger to cause the drug to exit the front opening. An elastic element is provided between the thrust members to store and release elastic energy when the first thrust member proximal to the drive member is manually actuated, thus causing the second thrust member proximal to the syringe to advance as the drug exits the front opening.

According to one example of the present disclosure an infusion device is configured to control a medication delivery apparatus to intravenously deliver a pharmaceutical preparation to a patient. The infusion device comprises a processor and a memory storing instructions executable by the processor to cause the medication delivery apparatus to deliver the pharmaceutical preparation to the patient according to a predetermined dose profile. The predetermined dose profile is designed to deliver a therapeutic dose of the pharmaceutical preparation to the patient over a predetermined infusion time in a manner which facilitates safe detection of an adverse reaction of the patient to the pharmaceutical preparation, or desensitization the patient to the pharmaceutical preparation, during a first stage of administering the therapeutic dose.

An infusion system and method configured to identify a break in static friction between a plunger and an infusate cartridge during an infusion of infusate for the purpose of providing a more consistent flow of infusate and promoting a more efficient use of energy. The infusion system and method can include monitoring of force between a drive mechanism and the plunger for a decrease in a rate of the force over time during actuation of the drive mechanism, thereby indicating a break in static friction between the plunger and the cartridge, and determining a low power consumption sleep duration based on an advancement of the actuator following the break in static friction.

A medical device is disclosed, which includes: an operation reception unit; a position acquisition unit capable of acquiring position information of a detection target that is in contact with or proximity to the operation reception unit, the position information being based on a position on the operation reception unit; and a control unit that identifies an operation input by the detection target based on a change in the acquired position information.

A fluid pathway connection includes a piercing member, a connection hub, and a sliding pierceable seal, wherein the sliding pierceable seal is configured to move from a first position, where the piercing member is initially retained within a sterile cavity between the connection hub and the sliding pierceable seal, to a second position, where the pierceable seal has been penetrated by the piercing member. A filter may be utilized to enclose the sterile cavity from the outside environment. The fluid pathway connection may further be configured to move to a third position where one or more interconnects and/or one or more corresponding contacts are permitted to transmit a signal to the user. Such fluid pathway connections may be integrated into a drug container having a barrel and a plunger seal. A drug delivery pump includes such integrated fluid pathway connections and drug containers.

A user-initiated fluid pathway connection includes: a connection hub, a piercing member, a sterile sleeve, and a drug container having a cap, a pierceable seal, a barrel, and a plunger seal, wherein the piercing member is initially retained within the sterile sleeve between the connection hub and the pierceable seal of the drug container. The connection hub may include an internal aperture within the connection hub which functions as a flow restrictor and wherein a piercing member is connected to one end of the internal aperture and a fluid conduit is connected to another end of the internal aperture. A drug delivery pump with integrated sterility maintenance features includes a housing, upon which an activation mechanism, an insertion mechanism, a fluid pathway connection as described above, a power and control system, and a drive mechanism connected to a drug container are mounted. Methods of assembly and operation are also provided.

Devices for transferring fluid to or from a subject include a plunger assembly coupled to or coupleable to a cannula assembly to allow target fluid to be “front-loaded” into a distal end of the cannula assembly while the stylet is withdrawn a distance to create a vacuum and define a flow channel.

A fluid delivery device includes a housing having a bottom surface configured to be coupled to the skin surface. The fluid delivery device includes a cartridge prefilled with a fluid and configured to be inserted into the housing. The cartridge has a septum configured to be generally perpendicular to the bottom surface when the cartridge is inserted in the housing. The fluid delivery device includes a needle assembly that has a needle that includes a fluid coupling end and a delivery end. The fluid coupling end of the needle is fluidly disengaged from the cartridge in an initial position. The delivery end of the needle extends past the plane of the bottom surface and the fluid coupling end of the needle extends through the septum in a deployed position.

A fluid injector system (1000) is configured to perform an injection protocol. The fluid injector system includes a housing (11) and a controller (900) operatively associated with a user input device (40) and a fluid actuator (16). The controller includes at least one processor programmed or configured to determine an orientation of the housing, receive at least one signal from the user input device, determine a direction of fluid actuation based on the orientation of the housing and the at least one signal, and actuate the fluid actuator in the direction of fluid actuation. The direction of fluid actuation corresponds to at least one of actuating the fluid actuator to inject fluid from a fluid reservoir and actuating the fluid actuator to draw fluid into the fluid reservoir.

Delivery systems and their methods of use for delivering one or more therapeutic compounds to a user are described. A delivery system may include an implantable pump and an external actuator. The implantable pump may include an actuatable portion that may be actuated to dispense a volume of fluid. The external actuator may include a pusher configured to deform skin to engage an actuatable portion of the pump. The external actuator may also include a positioning magnet configured to magnetically attract a portion of the implantable pump such that the external actuator and the pump may be aligned prior to applying force to the portion of the skin between the external actuator and the actuatable portion of the pump.