A system for at least partial closed-loop control of a medical condition is disclosed. The system includes at least one medical fluid pump. The medical fluid pump including a sensor for determining the volume of fluid pumped by the pump. Also, at least one continuous analyte monitor, and a controller. The controller is in communication with the medical fluid pump and the at least one continuous analyte monitor. The controller includes a processor. The processor includes instructions for delivery of medical fluid based at least on data received from the at least one continuous analyte monitor.

Pump cassettes, wound-treatment apparatuses and methods. In some embodiments, a pump cassette comprises: a pump body having a pump chamber, an inlet valve in fluid communication with the pump chamber, and an outlet valve in fluid communication with the pump chamber; a diaphragm coupled to the pump body such that the diaphragm is movable to vary a volume in the pump chamber; and an identifier configured to store one or more properties of the pump cassette such that the identifier is readable by an automated reader to determine the one or more properties. In some embodiments, the pump cassette is configured to be removably coupled to a wound-treatment apparatus having an actuator such that the actuator can be activated to move the diaphragm.

This application relates to a wearable multi-shot injection patch. In one aspect, the patch includes a base that has a bottom surface and a top surface and is configured so that the bottom surface is disposed against a patient's skin. The patch may also include a first container that is supported by the base and accommodates a first drug, and a second container that is supported by the base and accommodates a second drug. The patch may further include a first pyrotechnic charge disposed between the top surface and the first container inside the base, and a second pyrotechnic charge disposed between the top surface and the second container inside the base. The patch may further include one or more electronic components configured to detonate the first pyrotechnic charge and the second pyrotechnic charge.

A device is disclosed that is configured as a fully autonomous and integrated wearable apparatus for diabetes management. The device comprise a self-pressurized reservoir for storing the medication for subsequent delivery to a patient, a needle for delivering the medication to the patient subcutaneously, a first MEMS device configured as a microvalve in a fluid path between the self-pressurized reservoir and needle for controlling flowrate of medication through the needle as the self-pressurized reservoir discharges, a second MEMS device configured as a micropump configured to increase flowrate of the medication in the fluid path to ensure a constant flowrate in the fluid path as the self-pressurized discharges independent of orientation of the device, a flow sensor configured to measure flowrate in the fluid path for controlling microvalve and micropump, and control circuitry connected to the microvalve, micropump and flow sensor for controlling operation of the micropump and microvalve.

A filling aid device for filling a reservoir. The device includes a cover portion comprising a septum window; a slider beam comprising a septum cover; and a first filling aid tab attached to the slider beam, the first filling aid tab in slidable relation to the cover from a first position to a second position, wherein when the filling aid device is in an unlocked position, the septum cover is located below the septum window, wherein when the first filling aid tab is moved from the first position to the second position, the septum cover is moved from below the septum window, and the filling aid device is in the locked position.

An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and pivotally movable about a pivot pin relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are pivotally movable about the pivot pin in a radially inward direction to engage with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.

A method of dispensing a therapeutic fluid from a line includes providing an inlet line connectable to an upstream fluid source. The inlet line is in downstream fluid communication with a pumping chamber. The pumping chamber has a pump outlet. The method also includes actuating a force application assembly so as to restrict retrograde flow of fluid through the inlet while pressurizing the pumping chamber to urge flow through the pump outlet. A corresponding system employs the method.

The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

A system for controlled delivery of a medical fluid may include an elastomeric pump, a valve member fluidly coupled to the elastomeric pump at one side and a catheter at an opposite side for delivering the medical fluid to a patient, and tubing fluidly coupling the elastomeric pump and the valve member. The elastomeric pump may include an elastomeric membrane and a shell surrounding the elastomeric membrane. The pressure of the medical fluid may be greater than a pressure of the vein to keep the vein open. The valve member may be movable between an initial closed position, a fully open position where the medical fluid is delivered to the vein of the patient at a predetermined fluid flow rate, and at least one intermediate open flow position where the medical fluid is delivered to the vein of the patient at a flow rate below the predetermined fluid flow rate.

A medicinal liquid supply control apparatus according to an embodiment of the present disclosure includes a reservoir located on a second channel to define an internal space that stores a medicinal liquid, an inlet hole and an outlet hole being formed in one portion of an outer surface of the reservoir and connected to the internal space, and a reservoir support part on which the one portion of the reservoir is fixed, an inlet connection hole connected to the inlet hole and an outlet connection hole connected to the outlet hole being formed at the reservoir support part.