A sensing system for sensing a potential complication at a venous catheter site. The system includes a sensor module for attachment at the site of the catheter. The sensor module includes a pressure sensor configured to generate pressure data representing measured pressure at the site of the catheter; a temperature sensor configured to generate temperature data representing measured temperature at the site of the catheter; and two pairs of bio impedance electrodes that generate bioelectrical signals representing bioelectrical activity at the site of venous catheter and a transmitter for transmitting the pressure, temperature data and bio impedance data. The system also includes a computing device configured to receive the response signal that includes the generated pressure, temperature and bio impedance data; and transmit the pressure temperature and bio impedance data to a user device for comparing the generated pressure temperature bio impedance data to threshold values indicative of intravenous complications.

Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device involves obtaining one or more measurement values of a physiological condition in the body of a user during an initial monitoring period and determining a fasting reference value for a metric based on the one or more measurement values. After the initial monitoring period, the method continues by obtaining an updated measurement value during a fasting period, determining a current value for the metric based at least in part on the updated measurement value, and generating a notification in response to a deviation between the current value and the fasting reference value exceeding a threshold indicative of insertion site loss or other loss of effectiveness.

A catheter system may include a catheter lumen, first and second electrodes, and a sensor in communication with the first and second electrodes. The sensor may be configured to detect at least one of: a bulk volume of blood within a blood vessel and extravasation of a drug from the blood vessel into soft tissue adjacent the blood vessel. Other catheter systems may include a catheter lumen and a sensing chip coupled to the catheter lumen. The sensing chip may be configured to detect at least one of: a bulk volume of blood within a blood vessel and extravasation of a drug from the blood vessel into soft tissue adjacent the blood vessel.

Systems and methods for drug delivery with pressure sensitive control are disclosed. A drug delivery system may include a reservoir filled or fillable with a drug, a drug delivery device coupled to the reservoir to deliver the drug from the reservoir to a patient, a pressure sensor, an output device, and a controller. The controller may be configured to determine if the drug delivery device has completed delivering a dose of the drug to the patient, and if delivery of the dose of the drug is complete, to measure tissue back pressure using the pressure sensor. Subsequently, the controller may be configured to determine if the tissue back pressure is below a first predetermined value, and if so, control the output device at least once and/or control a mechanism to retract an administration member from the patient.

Systems and methods are provided for measuring depth, position, and/or angle of a cannula in a medical drug delivery device. In particular, a drug delivery device having a cannula is positioned adjacent to tissue, a voltage pulse is provided to the cannula, a charge is measured at an electrode in the drug delivery device, and the depth of penetration of the cannula is determined based in part on the charge at the first electrode. Systems and methods described herein can be used to determine subcutaneous insertion depth in a wearable bolus injector. In some implementations, insertion depth determination is achieved through capacitive sensors which measure needle depth in a drug delivery device.

Infusion systems and methods for administering an infusion fluid into a patients anatomic space at a variable flow rate without flow control include an administration set having a flexible tube fluidically connected to a needle connector, the needle connector including a receiving end fluidically connected to flexible tube, and an administering end opposite the receiving end and fluidically connected with an infusion needle, and the infusion needle having an inside diameter of about 0.0104 inches to about 0.0135 inches and fluidically connected to the administering end of the flexible tubing to deliver the infusion fluid to the patients anatomic space at variable flow rates dependent upon the saturation of the infusion fluid at the patients injection site.

An automated dose-response record system including a module for housing waste-heat producing electronic and electromechanical medical equipment including at least one physiologic monitor, and including a system to measure, temporally correlate and record dose and response events.

Drug delivery system including: a reservoir having a meander shape or spiral shape, the reservoir including an inlet and a filter; a capacitance measurement device configured to determine a parameter of the reservoir; and a micropump configured to deliver a fluid from the reservoir to an outlet.

The present disclosure provides systems and methods for managing blood glucose in a subject. An insulin delivery cannula may comprise a hollow tube comprising proximal and distal ends, the proximal end in fluid communication with an insulin source, and the distal end configured to deliver insulin into a subcutaneous space. An insulin infusion pump may be fluidically coupled to the proximal end, and attached to the insulin delivery cannula directly or via an intervening tube. The glucose sensor and the insulin delivery cannula may be configured to be inserted into the subcutaneous space simultaneously by a single insertion device. A lumen of the insulin delivery cannula may be contiguous with a lumen of tubing from the insulin infusion pump. Electrical conductors for the electrodes may be disposed on a wall of the tubing or attached to a surface of the tubing, and establish an electrical connection with an electronic module.

Disclosed are an automatic medication delivery system includes a stress detection and response algorithm or application that may operate in cooperation with a medication delivery algorithm or application. Execution of the instructions of the stress detection and response application causes a processor to obtain a respective measurement value related to a physiological condition of a user from one or more sensors. The obtained respective measurement values are evaluated against a respective threshold measurement value. The processor determines, based on the evaluation of the obtained respective measurement values, a degree of stress the user is experiencing. In response to the determination of the degree of stress the user is experiencing, the processor may modify an imminent dosage of a liquid drug to be delivered, a time of delivery of the imminent dosage, or both. A dosage of the liquid drug may be expelled based on the modifying.