Method and system for providing basal profile modification in insulin therapy for use with infusion devices includes periodically monitoring the analyte levels of a patient for a predetermined period of time in order to determine, based on the monitored analyte levels, an appropriate modification factor to be incorporated into the underlying basal profile which was running at the time the periodic monitoring of the analyte levels were performed.

An ambulatory infusion pump can include a maximum bolus override procedure. When a bolus amount greater than a maximum bolus amount is requested, the pump can provide an alert indicating that the amount requested exceeds the maximum bolus amount. If the user confirms the request in response to the alert, the bolus amount can be delivered to the user. The amount delivered in response to the confirmation can be a first portion of the bolus amount. A reminder can then be provided that a second portion of the bolus amount that is a remaining portion of the requested bolus amount was also requested. If a second confirmation is received in response to the alert, the second portion of the bolus amount can also delivered to the user.

According to one example of the present disclosure an infusion device is configured to control a medication delivery apparatus to intravenously deliver a pharmaceutical preparation to a patient. The infusion device comprises a processor and a memory storing instructions executable by the processor to cause the medication delivery apparatus to deliver the pharmaceutical preparation to the patient according to a predetermined dose profile. The predetermined dose profile is designed to deliver a therapeutic dose of the pharmaceutical preparation to the patient over a predetermined infusion time in a manner which facilitates safe detection of an adverse reaction of the patient to the pharmaceutical preparation, or desensitization the patient to the pharmaceutical preparation, during a first stage of administering the therapeutic dose.

An injection system has: an injection device that injects a drug solution; and a sound detection device that detects sound while a subject is being imaged and generates first data based on the sound, wherein the injection device has a data generation unit that acquires the first data, and a history generation unit that generates injection history data of the drug solution, and the data generation unit generates second data in which the first data is associated with time data in common with the injection history data.

An injection system has: an injection device that injects a drug solution; and a sound detection device that detects sound while a subject is being imaged and generates first data based on the sound, wherein the injection device has a data generation unit that acquires the first data, and a history generation unit that generates injection history data of the drug solution, and the data generation unit generates second data in which the first data is associated with time data in common with the injection history data.

Disclosed herein are apparatuses and methods for a user-wearable infusion pump actuated with a shape memory alloy (SMA) wire. Embodiments enable an SMA wire driven infusion pump using a single length of SMA wire to provide multiple pulse sizes and corresponding medicament dispensing sizes. The multiple pulse sizes can include a larger pulse size for larger volumes to limit battery drain but smaller pulse sizes for precision of delivery.

Disclosed herein are apparatuses and methods for a user-wearable infusion pump actuated with a shape memory alloy (SMA) wire. Embodiments enable an SMA wire driven infusion pump using a single length of SMA wire to provide multiple pulse sizes and corresponding medicament dispensing sizes. The multiple pulse sizes can include a larger pulse size for larger volumes to limit battery drain but smaller pulse sizes for precision of delivery.

An apparatus including a controller can determine a rate of change of a blood glucose level of a subject from blood glucose data and determine if there is a risk of the blood glucose level going high or low.

Aspects of the present disclosure describe systems and methods for predicting an intra-aortic pressure of a patient receiving hemodynamic support from a transvalvular micro-axial heart pump. In some implementations, an intra-aortic pressure time series is derived from measurements of a pressure sensor of the transvalvular micro-axial heart pump and a motor speed time series is derived from a measured back electromotive force of a motor of the transvalvular micro-axial heart pump. Furthermore, in some implementations, machine learning algorithms, such as deep learning, are applied to the intra-aortic pressure and motor speed time series to accurately predict an intra-aortic pressure of the patient. In some implementations, the prediction is short-term (e.g., approximately 5 minutes in advance).

A pump device includes a pump driver comprising a first diaphragm and a second diaphragm, the first and second diaphragms each comprising a middle portion bounded by an outer portion, the first and second diaphragms being spatially separated from each other at the respective outer portions, and coupled together at the respective middle portions. The pump also includes a fluid passageway and a pump chamber fluidly connected to the fluid passageway, wherein the pump chamber comprises a moveable wall coupled to the pump driver at the middle portions of the first and second diaphragms such that a fluid movement between the pump chamber and the fluid passageway is induced by movement of the middle portions. An input device is configured to obtain a target flow rate. A controller is configured to operate the pump driver and a flow regulator based on signals received from a flow detector.