An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case arranged to be held by a user, a tubular chassis telescoped in the case and biased against the case so as to protrude from the case. The injector also includes a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe. A trigger button is distally arranged in or on the case, wherein the trigger button is initially coupled to the case in a manner to protrude distally from the case and interlocked to the chassis in a manner preventing the trigger button from disengaging the case.

A medicament delivery device system for delivery of a medicament from a cartridge (10). The system comprises a first container (11) for storage of a first substance, a second container (12) received in the first container (11) for storage of a second substance, and valve means (68) for closing a distal end of the second container (12). The system further comprises a disposable cassette (102) and a reusable firing unit (200). The cassette (102) has a body (104) for receiving the cartridge (10), and a mixing element (148) for displacing the second substance into the first chamber (16) in a mixing stroke, to mix with the first substance to form the medicament. The firing unit (200) comprises a drive element (208) for expelling the medicament from the first chamber (16) in a delivery stroke and a trigger arrangement (240) for initiating the delivery stroke.

The present disclosure is generally directed to a delivery device housed within an outer cartridge and useful for delivering a fluid to the IO space of a subject at a relatively constant volumetric flow rate over an extended period of time. The delivery device may be fluidly coupled to an existing IO access device or IV line positioned in the IO space of the subject or may be coupled to an IO access device disposed within the outer cartridge.

A fluid dispensing device adapted for intramuscular injection into a living organism is provided. The device has an energy storage arrangement providing energy in at least two bursts. The first burst is provided from a first energy source and is that which is necessary to pierce the skin of the living organism and insert the needle to the injection site. The second burst is provided by a second energy source and is that which is necessary to pump the fluid out of the reservoir and into the living organism. Optionally, the remaining energy is used to retract the needle out of the living organism. Together with a prescribed operating sequence of the device, use of the two sources of energy contained in the device is optimized to provide the at least two bursts of energy.

Drug delivery devices are provided having a needle assembly portion and a drug device portion, where the needle assembly portion is removably coupleable to the drug device portion. In some embodiments, the needle of the needle assembly may be moveable from a retracted position to an extended position for piercing into a subjects skin. In some embodiments, the needle may also be moveable back to a retracted position.

A device for extracting a fluid from an ampoule, comprising a plunger body (2) arranged for enclosing an ampoule (3), and a syringe body (4) movable relative to the plunger body (2). The syringe body (4) comprises a piston member (6) and an outer tubular casing (8) concentrically arranged around the piston member (6). The piston member (6) comprises an insertion end (10), receivable within the plunger body (2) and arranged for insertion in the ampoule (3), an ejection end (12) attached to the outer tubular casing (8), and a lumen (14) extending between the insertion end (10) and the ejection end (12). The plunger body (2) and the syringe body (4) form an actuating arrangement of the device (1) arranged to move the piston member (6) through the ampoule (3) during operation and forcing a fluid from the ampoule (3) through the lumen (14).

An injection device (100), including a base (104), a sliding body (116) slidably connected to the base (104), a double-ended needle (120) fixed to the sliding body (116), a biasing member (124) for proximally biasing the sliding body (116) with respect to the base (104), and for retracting the needle (120) into the device (100) subsequent to activation of the device (100), a medicament cartridge (128) for holding a medicament, slidably connected to the sliding body (116), and a stopper (132) slidably disposed within the medicament cartridge (128). The base (104) has a proximal end (108) and a surface (164) disposed at a distal end (112) thereof for contacting a patient's skin. The base (104) also has a first locking mechanism. The sliding body, (116) has a locking feature and a second locking mechanism. The second locking mechanism locks the medicament cartridge (128) relative to the sliding body (116) upon completion of displacement of the medicament cartridge (128) relative to the sliding body (116). The first locking mechanism and the locking feature interact to lock the sliding member (116) relative to the base subsequent to retraction of the needle (120) into the device (100).

A storage and mixing device includes a mixing compartment, two pistons that each extend from the mixing compartment and end in a displacement section, each piston defining a passageway having a first opening communicating with the mixing compartment and a second opening communicating with an inlet at the displacement section, and a housing having two piston guides and a cartridge compartment connected to the piston guide, each piston guide slidably receiving one of the pistons, and each cartridge compartment receiving a removable cartridge that includes a cavity for containing separate substances and an opening sealed by a cartridge seal. The displacement section of each piston includes a piercing member for piercing the cartridge seal of the cartridge arranged in the corresponding cartridge compartment, such that the displacement section enters the cartridge cavity and displaces the contained substance into the mixing compartment via the inlet and the passageway.

A dental anesthetic buffer system has a carpule having a first end and a second end, a capsule at least partially disposed within the carpule proximate the first end so as to fluidly seal the first end, and a membrane disposed proximate the second end so as to fluidly seal the second end. A liquid anesthetic is contained within the carpule between the first end and the second end. A liquid buffer is contained within the capsule. An activator is disposed proximate the buffer and extends from the carpule first end. The activator is manually moved from a first position to a second position so as to release the buffer from the capsule and combine the buffer with the anesthetic.

An apparatus includes a housing, an energy storage member, a carrier, a medicament container, and a delivery control mechanism. The housing defines a gas chamber configured to receive pressurized gas from the energy storage member to pressurize the gas chamber. The carrier has a proximal surface that defines a portion of the gas chamber. The medicament container is coupled to the carrier and has a distal end portion coupled to a delivery member. The medicament container contains a medicament and includes an elastomeric member that seals the medicament within the medicament container. The delivery control mechanism is coupled to a proximal end portion of the medicament container and includes a flow restriction member for regulating a pressure supplied by the gas chamber and entering into the medicament container that acts on the elastomeric member.