A mixing vial having a hollow interior chamber with a tubular portion having distal and proximal open ends and a stopper positioned in sealing relationship in the tubular portion, the stopper having a hollow interior chamber with an open end and a dislodgeable plug positioned in and sealing the open end.

A system for injecting includes a syringe body defining a proximal opening and a distal needle interface. The system also includes a plunger member defining a plunger interior and configured to be manually manipulated to insert a stopper member relative to the syringe body. The plunger member includes a needle retention feature disposed in the plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The system further includes a needle hub assembly coupled to the distal needle interface of the syringe body. The needle assembly includes a needle having a needle proximal end feature, a hub, and a needle latching member configured to couple the needle to the hub. The needle is retractable into plunger interior upon manipulation of the plunger member to actuate the energy-storage member latching member.

The present disclosure relates to an injection device for expelling of a dose of a medicament. The injection device includes an elongated housing with a distal end and a proximal end opposite to the distal end. The elongated housing has a body and a protective cap. A medicament container has a barrel having a first cavity in a proximal direction by a first stopper slidably arranged inside the barrel. The protective cap is configured to abut on a distally facing abutment portion of the barrel. The body is configured to abut on a proximally facing abutment portion of the first stopper. The first stopper is movable in distal direction relative to the barrel from an initial position into a priming position by moving the protective cap along the proximal direction relative to the body from a preset position into an activation position.

A syringe device with preferred and alternate embodiments structured to store, mix (if appropriate), and dispense multiple compounds (fluids, gels, suspensions, powdered solids, etc.) without the need for multiple syringes or the repeated use of a syringe. In a first embodiment, the device stores two separate compounds for use and mixes the compounds before dispensing the combined mixture. In a second embodiment, the device stores two separate fluids for use and dispenses the first fluid followed sequentially by dispensing the second. The device may be used with a variety of dispensing structures such as an applicator or a cannula (syringe needle). The present invention finds specific application, for example, in a syringe device for storing and combining a diluent with a lyophilized drug/vaccine. Overall, the device structures a unique arrangement of chambers and channels for the accurate storage, mixing, and dispensing of multiple compounds (fluids, gels, suspensions, powdered solids, etc.).

A method for preparing a pre-filled multi-chamber injection system includes providing an injection system body, the injection system body defining an open proximal end, a body interior, and an open distal end. The method also includes introducing a first substance into a distal end of the body interior. The method further includes disposing a distal stopper member in the body interior, the distal stopper member and the injection system body defining proximal and distal chambers in the body interior. Moreover, the method includes introducing a second substance into the body interior. In addition, the method includes disposing a proximal stopper member in the body interior. The method also includes inserting an elongate member at least partially into the body interior, the elongate member having a plurality of flow channels for fluidly coupling the proximal and distal chambers. The method further includes coupling a plunger member to the proximal stopper member.

Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

Disclosed herein are systems and methods for the injection of viscous fluids. For example, inventive systems and methods for injecting viscous fluids, such as concentrated drug formulations, via droplet lubrication are described.

The single-use safety syringe having a manual and/or automatic retracting needle preventing re-use thereof comprises a needle, a piston with a tightening seal and a cylindrical body having, at an end thereof, a connector provided with a calibrated attaching hole for the needle and open, at another end thereof, for inserting the piston, comprising, internally of the cylindrical body, a separating seal of a first chamber comprised between the separating seal and the connector in which a first active ingredient is positioned and a second chamber comprised between the separating seal and the tightening seal in which a second active ingredient is positioned, the separating seal having a connecting channel between the first and second chamber, closed by a pressure limiting valve, first engaging means further being provided, activatable for engaging the separating seal to the needle and second engaging means activatable for engaging the separating seal to the piston.

A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments, and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

The present disclosure provides methods of preparing a medical solution. In some aspects, the medical solution can be prepared from mixing a first liquid with a second liquid or mixing a solid component with a liquid in an autoinjector. In some aspects, the heat released from the mixing can promote solubility of a dry medicament in the solution.