A drive mechanism for a medication delivery device containing a resilient member and having a rotation member configured to be rotated in a first direction during setting of a dose of a medication and to be rotated in a second direction during delivery of the dose, where the rotation member is coupled to a drive member that is coupled to a piston rod such that on dose delivery the piston rod is displaced in a distal direction to dispense a medicament and where the resilient member prevents movement of the drive member and the piston rod during dose setting.

A plunger (1) for a medical delivery device comprises: a rod element (2) having a distal end (22) and a proximal end, and a stopper (3) mounted to the rod element (2) at its distal end (22). The rod element (2) has a first form fit structure (24) and the stopper (3) has a second form fit structure (31). The stopper (3) is locked to the rod element (2) by the first form fit structure (24) of the rod element (2) and the second form fit structure (31) of the stopper (3) engaging each other.

Fluid dispensing device, having a pump connected to a reservoir and to a head. A piston (22) is connected to a piston rod (25) and provided with a push-button (26) to actuate the pump. A spring (27) brings the piston to the rest position after actuation. The body has a T-like connection (24), with a first branch connected to the metering chamber, a second branch connected to the reservoir and a third branch is connected to the head. A first valve (41) is provided in the second branch and a second valve (51) in the third branch, the valves are urged against the first and second respective valve seats (43, 53). The device has dose a adjustment (28, 29) cooperating with the piston rod and has a bush (29) coaxially around the piston rod movable to adjust the rest position of the piston.

The invention relates to a pre-filled injection device with a non-removable cartridge embedded in the housing structure and wherein the piston rod drive mechanism comprises a threaded piston rod which is moved helically in a nut secured to the housing structure. During assembly of the injection device it is possible to eliminate the air-gap between the plunger in the cartridge and the piston rod means by moving the nut element for the drive mechanism axially during assembly. In an alternative solution, the piston rod comprises a telescopic element which can slide axially in relation to the piston rod to obtain the zero position.

A syringe (1) comprises a barrel (2), a stopper (3) and a plunger (4). The barrel (2) has a hollow interior, an orifice (21) and an opening (22) opposite to the orifice (21). The stopper (3) is arranged in the hollow interior of the barrel (2) thereby defining a sealed chamber (5) in the interior of the barrel (2). The stopper (3) is displaceable in the interior of the barrel (2) thereby varying a volume of the chamber (5). The plunger (4) extends through the opening (22) of the barrel (2) into the hollow interior of the barrel (2). The plunger (4) has a distal end (41) outside of the barrel (2) and a proximal end (42) inside the hollow interior of the barrel (2). The stopper (3) has a distal face (31) directed towards the plunger (4), a proximal face (32) directed towards the chamber (5) and an internal cavity (33) opening at the distal face (31). The syringe (1) is equipped with a sealing structure sealing the cavity (33) of the stopper (3) such that the cavity (33) of the stopper (3) is microbiologically sealed.

The present invention provides a two-step auto-injection apparatus consisting of a housing, a protective sleeve cylinder, a pre-filled injection assembly and a drive feedback apparatus, wherein the pre-filled injection assembly is loaded into the housing, and the protective sleeve cylinder covers a needle of the pre-filled injection assembly, so that the protective sleeve cylinder directly contacts an injecting portion and the function of injection can be realized by pressing to trigger the drive feedback apparatus during use, thereby facilitating quick operation with a needle tip hidden in the whole process; the drive feedback apparatus of a piston in a needle cylinder is driven to combine a release mechanism with an ejection mechanism and a feedback mechanism, and the release mechanism is triggered by pressing the protective sleeve cylinder, so that the ejection mechanism is released, and the ejection mechanism interacts with the feedback mechanism in a form of collision, for example, to generate a sound signal and/or a haptic signal in the moment of release for prompting a patient to begin an injection; when the ejection mechanism finishes movement, the ejection mechanism interacts again with the feedback mechanism in the form of collision, for example, to generate the sound signal and/or the haptic signal for promoting the patient to finish the injection.

A syringe system and components thereof are disclosed. The system may include a syringe body having a hollow lumen, a proximal open end, and a distal end. The syringe body may be configured to house a fluid therein. The syringe system may further include a plunger positioned in the hollow lumen of the syringe body, forming a seal with an inner wall of the syringe body. The plunger may include a removable piston having a shaft extending from the distal end towards the proximal open end, a stopper removably connected to a distal portion of the shaft, and at least one coupler attached to the distal portion of the shaft. The stopper may be configured to slidably move within the hollow lumen to facilitate movement of the fluid within the syringe body. The coupler may be configured to facilitate removal and attachment of the stopper from the piston.

A drug delivery device for sequentially delivering a predefined plurality of fixed doses, wherein the drug delivery device comprises a housing assembly, a drive mechanism comprising a drive tube and adapted to sequentially deliver the predefined plurality of doses, and an activation mechanism for activating the drive mechanism. The drive mechanism further comprises a pre-strained torsional drive spring (108, 208) conserving an initial amount of energy, and adapted for rotating the drive tube, wherein each activation of the drive mechanism, and completion of a drive tube dose sequence reduces the amount of conserved energy in the drive spring, and wherein the initial amount of conserved energy, which is the conserved energy before the first activation, is sufficient to deliver the predefined plurality of fixed doses.

Described herein is a generalized injection device for delivering formulations of various mechanical properties to precise locations. Of particular interest is the manifestation intended for the application of a thermally responsive hydrogel to the tear duct for the purpose of occlusion, as a treatment for symptoms associated with dry eye syndrome. Further, a modular solution to the need for an injection device across a variety of applications, mechanism, and physical considerations is provided. This disclosure provides examples of methods for precise injection of low volumes, moisture retention in pre-filled injection devices, and actuation for automatic or manual injection, to name a few.

A crawling mechanism for a drug delivery device has a central longitudinal axis and is arranged to crawl in an axial direction. The crawling mechanism includes a housing and one or more swing members pivotally coupled to the housing that are arranged to swing relative to the housing between an initial position and a terminal position suitable for urging crawling of the mechanism.