A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove and a helical spline. The inner housing helical spline guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing.

The present disclosure relates to a dosing mechanism for a drug delivery device for selecting and dispensing a number of user-variable doses of a medicament. The dosing mechanism comprises a housing, a piston rod, and a driving mechanism for rotating the piston rod and/or a movement application component, which is directly engaged with the piston rod, in a dispense rotational direction with respect to the housing for dose dispense. The dosing mechanism further comprises a rotational end stop mechanism for terminating dose dispense with a first engagement means, which is rotationally fixed with respect to the piston rod and/or the movement application component, and a second engagement means, which is prevented from rotation with respect to the housing in the dispense rotational direction at an end of dose dispense. In order to improve the dose delivery accuracy, the second engagement means directly engages the first engagement means. disclosure

A medication injection method where a dose set knob of a medication injection pen is rotated with respect to the housing of the medication injection pen during dose setting and dose correcting, a driver is selectively engages with the dose set knob, the driver being rotatably fixed with respect to the housing during dose setting and dose correcting, the driver is moved axially with the dose set knob during the dose setting and the dose correcting, and the driver is rotated with the dose set knob during an injection.

A drug injection device includes a housing with a cartridge having a predetermined drug volume, a dose setting mechanism for setting a drug dose, and a dose delivery mechanism. A dose setting service element rotates about a longitudinal axis during the drug dose setting. The dose setting mechanism has a last dose setting device to prevent setting of a drug dose greater than the drug volume remaining in the cartridge. The last dose setting device includes a pinion coaxial with the longitudinal axis that rotates about the longitudinal axis with the dose setting service element during drug dose setting, and a rack engaged with the pinion that moves parallel to the longitudinal axis when the pinion rotates. The pinion and the rack have mutual abutment elements that prevent further rotation of the pinion after the rack has travelled an axial length correlated to the predetermined drug volume.

Embodiments described herein generally relate to devices, systems and methods for measuring a volume or number of doses remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a light guide disposed and configured to reflect electromagnetic radiation toward the container. The dose measurement system also includes a light guide disposed and configured to emit electromagnetic radiation into the light guide. A plurality of sensors are located in the apparatus that are optically coupleable to the light guide and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light guide. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors. The processing unit is further operable to convert the received data into a signature representative of the electromagnetic radiation detected by the plurality of sensors.

A dosing mechanism for an injection device includes a dose-setting element with a first element coupled thereto, which, during dose setting, is rotatable relative to a second element about a main rotation axis in a first direction and, during dose discharge, is fixed in rotation relative to the second element. The first and the second elements are coupled via a sleeve-shaped stop element, which forms a stop abutment. The dosing mechanism includes a stop, and the stop abutment, during the rotation of the first element in the first direction, executes a movement to a stop position where the stop abutment strikes the stop and prevents rotation of the first element relative to the second element in the first direction of rotation. The sleeve-shaped stop element is rotatable about a secondary rotation axis, which is offset parallel to or offset at an angle to the main rotation axis.

A drug delivery device includes a housing and a movable member, which is arranged to be rotatable in an incrementing direction and a decrementing direction, the movable member being operatively coupled to an energy storage member and biased to rotate into the decrementing direction by energy stored or storable in the energy storage member. Rotation of the movable member in the incrementing direction increases the energy stored in the energy storage member. The drug delivery device also includes a locking system including a locking feature, a block feature, and a release member, wherein the locking feature is arranged to cooperate with the block feature to form a releasable locking interface configured such that, when the releasable locking interface is established, rotational movement of the movable member relative to the housing is blocked in the decrementing direction, and when the releasable locking interface is released, the movable member is rotatable in the decrementing direction.

Some aspects of the present disclosure relate to a drive mechanism for a drug delivery device. The drive mechanism includes: a piston rod to operably engage with a piston of a cartridge to displace the piston in a distal direction during a dose dispensing action, at least one actuation member mechanically coupled with the piston rod to induce a distally directed displacement of the piston rod when actuated by a user, a control to ascertain at least one predefined condition of use, and at least one interlock member coupled with the control to mechanically obstruct displacement of the piston rod if the condition of use is not fulfilled.

The present invention provides a piston rod displacement mechanism for a pen injection device, comprising: a tubular housing (2) extending along a reference axis and comprising an interior housing surface (3) with a first engagement structure (4), a nut member (5) fixed within the tubular housing (2), a piston rod (15) comprising a first non-self-locking thread (18) having a first thread direction and a first thread pitch and being engaged with the nut member (5), and a second non-self-locking thread (17) superposed on the first non-self-locking thread (18), the second non-self-locking thread (17) having a second thread direction and a second thread pitch, and a dose dial sleeve (20) operable to advance the piston rod (15) in the nut member (5), the dose dial sleeve (20) comprising an exterior sleeve surface (21) with a second engagement structure (24) being in sliding engagement with the first engagement structure (4), and an interior sleeve surface (23) with a third engagement structure (29) being engaged with the second non-self-locking thread (17). One of the first engagement structure (4) and the second engagement structure (24) comprises a closed-circuit track configuration and the other of the first engagement structure and the second engagement structure comprises a track follower, and the closed-circuit track configuration comprises a helical track portion (24h) having a helical track direction equaling the second thread direction and a helical track pitch equaling the second thread pitch, and an axial track portion (24a) extending between a distal track end (24d) and a proximal track end (24p) and being connected to the helical track portion (24h) at the distal track end (24d).

A drug injection device includes a housing with a cartridge having a predetermined drug volume, a dose setting mechanism for setting a drug dose, and a dose delivery mechanism. A dose setting service element rotates about a longitudinal axis during the drug dose setting. The dose setting mechanism has a last dose setting device to prevent setting of a drug dose greater than the drug volume remaining in the cartridge. The last dose setting device includes a pinion coaxial with the longitudinal axis that rotates about the longitudinal axis with the dose setting service element during drug dose setting, and a rack engaged with the pinion that moves parallel to the longitudinal axis when the pinion rotates. The pinion and the rack have mutual abutment elements that prevent further rotation of the pinion after the rack has travelled an axial length correlated to the predetermined drug volume.