According to one example of the present disclosure an infusion device is configured to control a medication delivery apparatus to intravenously deliver a pharmaceutical preparation to a patient. The infusion device comprises a processor and a memory storing instructions executable by the processor to cause the medication delivery apparatus to deliver the pharmaceutical preparation to the patient according to a predetermined dose profile. The predetermined dose profile is designed to deliver a therapeutic dose of the pharmaceutical preparation to the patient over a predetermined infusion time in a manner which facilitates safe detection of an adverse reaction of the patient to the pharmaceutical preparation, or desensitization the patient to the pharmaceutical preparation, during a first stage of administering the therapeutic dose.

A wearable infusion pump assembly. The wearable infusion pump assembly includes a reservoir for receiving an infusible fluid and a fluid delivery system configured to deliver the infusible fluid from the reservoir to an external infusion set. The fluid delivery system includes a controller, a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the external infusion set, the pump assembly comprising a pump plunger, the pump plunger having distance of travel, the distance of travel having a starting position and an ending position, at least one optical sensor assembly for sensing the starting position and ending position of the pump plunger distance of travel and sending sensor output to the controller, and a first valve assembly configured to selectively isolate the pump assembly from the reservoir, wherein the controller receives the sensor output and determines the total displacement of the pump plunger.

A wearable infusion pump assembly. The wearable infusion pump assembly includes a reservoir for receiving an infusible fluid and a fluid delivery system configured to deliver the infusible fluid from the reservoir to an external infusion set. The fluid delivery system includes a controller, a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the external infusion set, the pump assembly comprising a pump plunger, the pump plunger having distance of travel, the distance of travel having a starting position and an ending position, at least one optical sensor assembly for sensing the starting position and ending position of the pump plunger distance of travel and sending sensor output to the controller, and a first valve assembly configured to selectively isolate the pump assembly from the reservoir, wherein the controller receives the sensor output and determines the total displacement of the pump plunger.

This invention is an air block for industrial, medical, and non-medical uses. For example, the air block is connected to the proximal end of a vascular access catheter. The air block is either removably connected to the proximal end of the catheter or it is integral to the proximal end of the catheter. The air block permits introduction of other catheters or instrumentation through its central lumen and on into a lumen of the catheter while minimizing fluid loss or gain into the catheter. The air block further prevents air from entering the catheter and provides for removal of the air or other gas from the central lumen before it can enter the catheter where it could cause harm to the patient. The air block can be attached to various standard proximal catheter terminations including Luer fittings and hemostasis valve outer barrels.

This invention is an air block for industrial, medical, and non-medical uses. For example, the air block is connected to the proximal end of a vascular access catheter. The air block is either removably connected to the proximal end of the catheter or it is integral to the proximal end of the catheter. The air block permits introduction of other catheters or instrumentation through its central lumen and on into a lumen of the catheter while minimizing fluid loss or gain into the catheter. The air block further prevents air from entering the catheter and provides for removal of the air or other gas from the central lumen before it can enter the catheter where it could cause harm to the patient. The air block can be attached to various standard proximal catheter terminations including Luer fittings and hemostasis valve outer barrels.

Disclosed is a combination of an infusion set consisting of infusion tubing and needle connected to a drug cartridge, the latter comprising a cylindrical body of inner diameter and having an open rear end, wherein a stopper is slidably disposed within the body. In an initial state after the cartridge has been filled, the stopper is partially disposed within the body such that the stopper protrudes from the rear end of the body by a distance. Pushing the stopper into the cartridge by said distance, i.e. until the stopper is flush with the rear end, displaces a predetermined volume according to E, B and the cylindrical geometry of the cartridge, which is large enough to effect complete air priming of the cartridge, infusion tubing and infusion needle.

A valve assembly including a housing having a base and an outer shell, which forms a proximal cavity and a distal cavity joined by a canal; an inner housing configured for longitudinal movement within the distal cavity; a seal positioned within the distal cavity that together with the longitudinal movement of the inner housing regulates the flow of fluid through the valve assembly; and one or more selected from the group consisting of the base notched with one or more notches and the inner housing having one or more through slots aligned to permit access to the one or more notches, the seal being a reversibly deformable sealing pin, and a torque limiter mechanism configured to resist the longitudinal movement of the inner housing distally until a sufficient radial force is applied.

A system and method for determining the fill volume of a fluid chamber includes a fluid injector, at least one fluid chamber in fluid communication with the fluid injector, one or more sensors positioned relative to the at least one fluid chamber and configured to detect a position of a liquid-gas interface of the fluid contained in the at least one fluid chamber, and at least one processor in communication with the sensors and the fluid injector, and configured to: determine the position of the liquid-gas interface of the fluid, calculate the volume of fluid in the at least one fluid chamber based on the position of the liquid-gas interface, and at least one of: i) display the volume of the fluid; ii) enable the fluid injector to perform an action; and iii) disable the fluid injector from performing the action.

A wearable infusion pump assembly. The wearable infusion pump assembly includes a reservoir for receiving an infusible fluid and a fluid delivery system configured to deliver the infusible fluid from the reservoir to an external infusion set. The fluid delivery system includes a controller, a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the external infusion set, the pump assembly comprising a pump plunger, the pump plunger having distance of travel, the distance of travel having a starting position and an ending position, at least one optical sensor assembly for sensing the starting position and ending position of the pump plunger distance of travel and sending sensor output to the controller, and a first valve assembly configured to selectively isolate the pump assembly from the reservoir, wherein the controller receives the sensor output and determines the total displacement of the pump plunger.

A wearable infusion pump assembly. The wearable infusion pump assembly includes a reservoir for receiving an infusible fluid and a fluid delivery system configured to deliver the infusible fluid from the reservoir to an external infusion set. The fluid delivery system includes a controller, a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the external infusion set, the pump assembly comprising a pump plunger, the pump plunger having distance of travel, the distance of travel having a starting position and an ending position, at least one optical sensor assembly for sensing the starting position and ending position of the pump plunger distance of travel and sending sensor output to the controller, and a first valve assembly configured to selectively isolate the pump assembly from the reservoir, wherein the controller receives the sensor output and determines the total displacement of the pump plunger.