An infusion system and method configured to identify a break in static friction between a plunger and an infusate cartridge during an infusion of infusate for the purpose of providing a more consistent flow of infusate and promoting a more efficient use of energy. The infusion system and method can include monitoring of force between a drive mechanism and the plunger for a decrease in a rate of the force over time during actuation of the drive mechanism, thereby indicating a break in static friction between the plunger and the cartridge, and determining a low power consumption sleep duration based on an advancement of the actuator following the break in static friction.

An injection system can have a Syringe Dose and Position Apparatus (SDPA) mounted to a syringe. The SDPA can have one or more circuit boards. The SDPA can include one or more sensors for determining information about an injection procedure, such as the dose measurement, injection location, and the like. The SDPA can also include a power management board, which can be a separate board than a board mounted with the sensors. The syringe can also include a light source in the needle. Light emitted from the light source can be detected by light detectors inside a training apparatus configured to receive the injection. The syringe can have a power source for powering the sensors and the light source. The SDPA and the power source can be mounted to the syringe flange.

An injection system can have a Syringe Dose and Position Apparatus (SDPA) mounted to a syringe. The SDPA can have one or more circuit boards. The SDPA can include one or more sensors for determining information about an injection procedure, such as the dose measurement, injection location, and the like. The SDPA can also include a power management board, which can be a separate board than a board mounted with the sensors. The syringe can also include a light source in the needle. Light emitted from the light source can be detected by light detectors inside a training apparatus configured to receive the injection. The syringe can have a power source for powering the sensors and the light source. The SDPA and the power source can be mounted to the syringe flange.

An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

A calibration system for calibrating a pressure output of a fluid injector having a housing configured for connecting to the fluid injector; a drive member engagement portion configured for contacting a drive member of the fluid injector; a compressible member, which may have a known modulus of compression, connected at its proximal end to the drive member engagement portion, wherein the compressible member is compressed with movement of the drive member of the fluid injector between a first, uncompressed position and a second, at least partially compressed position of the fluid injector in a distal direction; and a sensor connected to the compressible member is described. The sensor is configured for measuring at least one of a force imparted by the drive member and a displacement of the drive member when the compressible member is in the second, at least partially compressed position. The system may generate a calibration curve for the drive member of the fluid injector and allow the generation of a fault condition. Methods for calibrating a fluid injector are also described.

A device for positioning a needle tip to a desired location by signaling pressure change is provided. The device includes a barrel, a piston, a biasing element, and a plunger. The barrel defines a reservoir, and it includes a distal end connectable to a puncturing apparatus. The plunger is slidably engaged with the piston, and both are movable within the reservoir. The biasing element connects the plunger and the piston, and its change in length corresponds to the relative position of the plunger and piston. In operation, the piston is at a first position relative to the plunger when the biasing element is at a first length. The piston later moves to a second relative position in response to the biasing element's change of the length resulting from a pressure change inside the reservoir when the puncturing apparatus reaches a location of a mass. The position's change of the piston is visually detectable.

A device for positioning a needle tip to a desired location by signaling pressure change is provided. The device includes a barrel, a piston, a biasing element, and a plunger. The barrel defines a reservoir, and it includes a distal end connectable to a puncturing apparatus. The plunger is slidably engaged with the piston, and both are movable within the reservoir. The biasing element connects the plunger and the piston, and its change in length corresponds to the relative position of the plunger and piston. In operation, the piston is at a first position relative to the plunger when the biasing element is at a first length. The piston later moves to a second relative position in response to the biasing element's change of the length resulting from a pressure change inside the reservoir when the puncturing apparatus reaches a location of a mass. The position's change of the piston is visually detectable.

Cellular therapy infusion devices for the delivery of media including cellular therapies to a patient's tissue, cells, and/or blood include a barrel, a plunger that fits within the barrel, a syringe shaft, and a pressure relief system configured to achieve and/or maintain a desired level of pressure and/or force within the device so that cellular behavior and/or viability is not adversely impacted by the mechanical forces exerted thereon via depressing the plunger into the barrel so the cellular therapy media may be pushed from the barrel into a patient delivery device for administration to the patient. The cellular therapy infusion devices may cooperate with and/or fit into cellular therapy infusion systems designed to create and/or maintain preferred conditions for the cellular therapy media stored in the barrel and automatically administer the cellular therapy media from the cellular therapy infusion device to the patient in a steady, regulated, and/or preferred manner.

An ocular medical injector is provided for drug delivery. A method includes inserting a puncture member of the medical injector into the eye until the puncture member reaches the SCS. The puncture member defines a lumen therethrough. With the puncture member disposed within the SCS, a flexible cannula is advanced distally through the lumen of the puncture member, beyond the distal end portion of the puncture member and along the SCS towards a posterior region of the eye. The flexible cannula has an atraumatic distal tip and defines a lumen therethrough. With the distal tip of the flexible cannula disposed within the SCS beyond a distal end portion of the puncture member, a therapeutic substance is administered to the SCS.

The present disclosure relates in one aspect to a measuring arrangement for measuring a volume occupied by a liquid medium inside a liquid reservoir, the measuring arrangement including a container having an interior volume containing a gas reservoir filled with a gaseous medium and containing a liquid reservoir filled with a liquid medium, wherein the gas reservoir and the liquid reservoir are hermetically separated by an impenetrable separation wall, a volume modulator to induce a volume change of the gas reservoir, a pressure sensor arranged inside the gas reservoir to measure a pressure change of the gaseous medium in response to the volume change of the gas reservoir, and a controller connectable to the pressure sensor, wherein the controller is configured to calculate the volume of the liquid reservoir on the basis of the pressure change and the volume change.