An implantable pump includes a rigid housing with an oblate spheroid shape and having an inner chamber divided by a movable elastomeric membrane into a gas sub-chamber which is connectible through a drive line to an external pneumatic source, and a blood sub-chamber which is connectible through a graft assembly to an anatomical heart. The housing includes a blood port opening oriented at an angle and at the upper apex of the housing and connected to the blood sub-chamber, and a gas port opening to the gas sub-chamber that is situated at a lower apex of the housing. The pump is provided with a drive line that includes a gas conduit and a heart sensor, the drive line connectible to a drive system that is capable of delivering gas flow through the drive line gas conduit in response to signals driven by the heart sensor.

An implantable pump includes a rigid housing with an oblate spheroid shape and having an inner chamber divided by a movable elastomeric membrane into a gas sub-chamber which is connectible through a drive line to an external pneumatic source, and a blood sub-chamber which is connectible through a graft assembly to an anatomical heart. The housing includes a blood port opening oriented at an angle and at the upper apex of the housing and connected to the blood sub-chamber, and a gas port opening to the gas sub-chamber that is situated at a lower apex of the housing. The pump is provided with a drive line that includes a gas conduit and a heart sensor, the drive line connectible to a drive system that is capable of delivering gas flow through the drive line gas conduit in response to signals driven by the heart sensor.

Mechanical circulatory supports configured to operate in series with the native heart are disclosed. In an embodiment, an intravascular propeller is installed into the descending aorta and anchored within via an expandable anchoring mechanism. The propeller and anchoring mechanism may be foldable so as to be percutaneously deliverable to the aorta. The propeller may have foldable blades. The blades may be magnetic and may be driven by a concentric electromagnetic stator circumferentially outside the magnetic blades. The stator may be intravascular or may be configured to be installed around the outer circumference of the blood vessel. The support may create a pressure rise between about 20-50 mmHg, and maintain a flow rate of about 5 L/min. The support may have one or more pairs of contra-rotating propellers to modulate the tangential velocity of the blood flow. The support may have static pre-swirlers and or de-swirlers. The support may be optimized to replicate naturally occurring vortex formation within the descending aorta.

A pump system is provided comprising a diaphragm fluid pump which can be fluidically connected to a heart and/or at least one blood vessel by means of an inlet cannula and an outlet cannula and is adapted for generating a pulsatile fluid flow for supporting a cardiac activity of the heart, a working pressure source connected to the diaphragm fluid pump by means of a pressure line and adapted for providing a working pressure for driving the diaphragm fluid pump, a control unit adapted for controlling the working pressure, a first flow sensor adapted for detecting a first cannula flow signal corresponding to an inlet flow in the inlet cannula or an outlet flow in the outlet cannula, a working pressure sensor adapted for detecting a working pressure signal corresponding to the working pressure in the pressure line.

A device and method for diverting a portion of oxygenated blood from a lower pressure region, e.g., left atrium or pulmonary vein, and providing it to the aorta, bypassing the left ventricle, operating at least in part, on the Venturi effect. The device includes a first conduit that diverts a portion of blood from the aorta to a parallel flow path. The device includes a second conduit that delivers blood from the lower pressure region to the first conduit. The blood from the lower pressure region in the second conduit is combined with the blood from the aorta in the first conduit and returned to the aorta. The second conduit is coupled to the first conduit at or near a narrow segment of the first conduit. A Venturi effect at or near the narrow segment draws the blood from the lower pressure region into the first and/or second conduit.

An implantable renal replacement therapy device may include: a first catheter configured to be inserted into a blood vessel in a subject's body; a pump in fluid communication with the first catheter, the pump is configured to pump subject's blood from the blood vessel; a filter in fluid communication with the pump, the filter is configured to: receive the subject's blood from the pump, and filter the received blood to provide a filtered blood and a filtrate liquid, wherein the filter is in fluid communication with the first catheter to cause an outflow of the filtered blood from the filter to the blood vessel; and a second catheter in fluid communication with the filter and configured to be inserted into an urinary bladder in the subject's body to cause an outflow of the filtrate liquid from the filter to the urinary bladder.

The present disclosure provides medical devices, systems and methods and in particular to devices and methods useful for anchoring graft materials to bodily structures.

The present technology provides a blood pump device and associated systems and methods of use thereof to assist blood circulation in a patient. The blood pump device includes a flexible member disposed within a housing. Movement of the flexible member in the housing varies the volume of chambers within the housing and effectuates pumping of blood to and from a vessel in fluid connection with a chamber of the blood pump device.

A system and method for increasing the speed of blood and wall shear stress (WSS) in a peripheral vein for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the vein is provided. The method includes pumping blood at a desired rate and pulsatility. The pumping is monitored and adjusted, as necessary, to maintain the desired blood speed, WSS and pulsatility in the peripheral vein in order to optimize the rate and extent of dilation of the peripheral vein.

A system and method for increasing the speed of blood and wall shear stress (WSS) in a peripheral vein for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the vein is provided. The method includes pumping blood at a desired rate and pulsatility. The pumping is monitored and adjusted, as necessary, to maintain the desired blood speed, WSS and pulsatility in the peripheral vein in order to optimize the rate and extent of dilation of the peripheral vein.