Disclosed is an energy self-sufficient real time bio-signal monitoring and nutrient and/or drug delivery system based on salinity gradient power generation. The energy self-sufficient real time bio-signal monitoring and/or nutrient delivery system based on salinity gradient power generation includes: an electricity generation and nutrient and/or drug delivery module including a reverse electrodialysis device which generates electricity by using a nutrient and/or drug solution and discharge a diluted nutrient solution; and a bio-signal measuring unit inserted into the electricity generation and nutrient and/or drug delivery module and configured to receive electricity from the electricity generation and nutrient and/or drug delivery module and measure a bio-signal.

Iontophoretically administering a cosmetic agent requires an active electrode and a return electrode secured to the skin (150). The active electrode includes a flexible biocompatible substrate (20, 170) having a therapeutic face (106, 206) configured for disposition toward the skin (150) and an exterior periphery (32, 182) shaped to facilitate conformance of the substrate (20, 170) to the skin (150) over an intended treatment region. A flexible electrically conductive layer (110, 210) is disposed on the therapeutic face (106, 206). The side of the conductive layer (110, 210) opposite from the substrate (20, 170) defines a driving face (120, 220) to which is affixed an electrically conductive adhesive matrix (82, 192) comprised of a material capable of repeatedly releasably securing the active electrode to the skin (150) through an applied solution (156, 158) of the cosmetic agent. A power source (76, 186) electrically connectable to the return electrode and to the conductive layer (110, 210) of the active electrode causes migration of the cosmetic agent away from the adhesive matrix (82, 192) into the skin (150).

A patch having at least first and second parts is applied to the skin to prepare the skin for a transdermal device to be applied subsequently. The second part defines the area of the skin in which the required preparation process should be carried out, either by removal of a third part to form an opening in the second part or by providing preparation means such as microneedles on the underside of the second part. The second part is then removed to leave the first part adhered to the skin, which can be used as a guide for correctly locating the transdermal device so that the working area of the device and the prepared area of the skin are in alignment.

Disclosed herein are formulations of dexamethasone or a prodrug thereof suitable for delivery by ocular iontophoresis and methods of use thereof.

One subject of the invention is an article for cosmetic treatment of a body area with an electric current, comprising a support (50) comprising an electrode (1) and a counter electrode (2), said electrode and counter electrode being separated from one another by a space comprising an electrically insulating zone (3) made of a polymeric material.

The present invention relates to a device for applying a cosmetic composition (P), comprising: —a capsule (1) that delimits a housing (10), —an application member (6) positioned in the housing (10) and impregnated with a cosmetic composition (P), —an electric exciter (29) comprising at least two electrodes (4, 5) in contact with the application member (6) and making it possible to circulate an electric current between these two electrodes (4, 5).

Provided is a patch able to produce micro-current to be applied on human skin including a support for electrodes spaced from each other and apt to create voltages typical of galvanic piles, connection means between the electrodes, an adhesive layer applied on one side of the support and apt to adhere to the skin and a protection liner applied on the adhesive layer, the support being a membrane permeable to the moisture inside the electrodes, and the connection means being defined by a material that is avid of moisture, such as silica impregnating the membrane.

Tumors in portions of a subject's body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region.

Disclosed is a sheet mask for iontophoresis including: a first boring portion which is formed at least one portion of portions corresponding to eyes, a nose, and a mouth of a user face; and a second boring portion which is formed to connect an electrode portion, wherein the number of second boring portions is one to six.

A skin dressing comprising first and second electrodes, an electrical power supply not electrically connected to either or both of the first and second electrodes, and further comprising a physiologically or antimicrobially active precursor substance, the dressing being operable, when placed on a skin site to be treated, to connect the electrical power supply to both the first and second electrodes, thereby to trigger the electrochemical oxidation or reduction of the precursor substance on one of the electrodes to produce a physiologically or antimicrobially active oxidized or reduced compound which is capable of diffusing towards the skin site for the treatment thereof.