A trial stimulation system includes a trial electrical stimulator. Additionally, systems for securing a disposable trial stimulator to the body of a patient are described, which may function to improve the durability of the system during the trial period and reduce the risk of damage or malfunction to the system due to lead/electrode dislocation and/or off-label uses like showering or bathing with the trial stimulator still secured to the body.

Electrodes that are configured to apply energy within the tissue while moving relative to the tissue. The apparatuses (devices, assemblies, systems) described herein may be configured with one or more electrodes that may move slightly in oscillatory movement and/or rotation relative to the tissue. The apparatuses described herein may be used to apply energy to a patient while minimizing or preventing the unintended modification of the tissue adjacent to the electrode, such as by arcing.

Disclosed herein are systems and methods for electrically modulating tissue. Systems can include a current generator; at least one implantable working electrode, the at least one implantable working electrode configured to be in electrical communication with the current generator; at least one indifferent electrode; and a controller configured to signal the current generator to: generate a set of currents with a set of initial polarities to be delivered to the working electrodes; and wherein the at least one indifferent electrode absorbs a bias current which is equal in magnitude and opposite in polarity to a summation of the set of currents.

This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 0.01 nanoseconds at the full-width-at-half-maximum. This treatment may at least prevent growth of the lesion.

A neuromonitoring needle electrode placement gun which includes a housing, at least a first needle electrode and housing assembly, an elongated channel dimensioned and configured for accommodating axial movement of the at least a first needle electrode and housing assembly within the channel and for directing movement of the at least a first needle electrode and housing assembly and a pusher dimensioned and configured for engaging the at least a first needle electrode and housing assembly and for axially displacing the at least a first needle electrode and housing assembly.

Disclosed herein are methods, devices, and systems for evaluation, diagnosis, prevention, and treatment of peripheral neuropathies.

Pursuant to embodiments of the present invention, a method of performing electronically controlled electrotherapy may include modifying or killing target cells and simultaneously modifying a secondary outcome by delivering electrical pulses and dynamically adjusting an energy delivery profile of the electrical pulses in response to a measurement. The secondary outcome may be a physical outcome, a biological outcome, and/or a systemic outcome.

A trial stimulation system includes a trial electrical stimulator. Additionally, systems for securing a disposable trial stimulator to the body of a patient are described, which may function to improve the durability of the system during the trial period and reduce the risk of damage or malfunction to the system due to lead/electrode dislocation and/or off-label uses like showering or bathing with the trial stimulator still secured to the body.

A novel electroporation device for the delivery of vaccines that is both effective in generating a protective immune response and tolerable delivery to a subject (or near painless); and also methods of using same device to vaccinate a subject against a variety of infectious diseases and types of cancer in a near painless.

A cosmetic method for treating a skin of a person is presented, the method comprises inserting one or more needles to one or more depths into the skin of the person such that at least a tip of at least one needle of the one or more needles is deployed within a muscle layer of the person's skin; applying a negative DC voltage to the one or more needles, while a skin of the person is in contact with a positive electrode to form one or more closed circuits of DC current through the person's body; and providing the DC current for a pre-selected amount of time to damage and/or ablate muscles and/or muscle nerve cells in the muscle layer; thereby providing a skin treatment comprising reducing and/or smoothing wrinkles from the person's skin.