In one aspect, an ingestible, electrical device, comprises one or more electrodes comprising a biocompatible conducting material and a biocompatible insulating material; a generator connected to the one or more electrodes; and an outer casing enclosing the one or more electrodes and the generator, the outer casing configured to dissolve in an aqueous environment of the organism; wherein the one or more electrodes have a first form factor when enclosed in the outer casing and a second form factor following a dissolution of the outer casing, the first form factor is a form factor that is collapsed an increased amount relative to an amount that the second form factor is collapsed, and the second form factor is a form factor that is collapsed a decreased amount relative to an amount that the first form factor is collapsed.

A cuff is described for a target anatomic feature within a body, along with a system for utilizing the cuff. The cuff includes a band defining a circumferential opening extending along a length of the band; and a pair of engagement surfaces defined by or affixed to the cuff, the engagement surfaces structured for application of a spreading force to be distributed continuously along a portion of the circumferential opening, thereby increasing the circumferential opening and expanding the cuff for a closed configuration to an open configuration sized for placement of the cuff. The cuff is structured to remain in the closed configuration in the absence of the spreading force and automatically return to the closed configuration after removal of the spreading force.

Example devices and techniques are disclosed for delivering neurostimulation therapy transesophageally. An example device includes stimulation circuitry configured to generate a transesophageal stimulation signal. The example device includes memory configured to store stimulation parameters that at least partially define the transesophageal stimulation signal and processing circuitry communicatively coupled to the memory, and the stimulation circuitry. The processing circuitry is configured to determine a maximum transesophageal stimulation amplitude value. The processing circuitry is configured to control the stimulation circuitry to generate the transesophageal stimulation signal based at least in part on at least one of the stimulation parameters or the maximum transesophageal stimulation amplitude such that an amplitude of the transesophageal stimulation signal does not exceed the maximum transesophageal stimulation amplitude.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent.

A system for fecal propulsion includes one or more sensors, a stimulator, one or more pairs of electrodes, a controller and a programming device. The sensors detect at least one marker of colonic activity from the enteric, autonomic and/or somatic nervous system. The stimulator generates energy of a particular waveform, intensity and/or time-course to modulate targeted neural circuitry with stimulation parameters being adaptable and dynamic to accommodate the various types of modulated tissues. The electrodes deliver stimulation to the enteric, autonomic and/or somatic nervous systems to control fecal propulsion. The controller and programing device change the stimulation parameters in real-time based on sensor feedback to acutely drive the circuitry from rest to productive defecation. The stimulation waveforms can be simultaneously or sequentially delivered to condition some tissues, while modulating others. The system is adaptive and can be driven through a data analytic repository and machine learning algorithm.

Methods of preventing, treating, and/or controlling a hemorrhage in an organ of a patient include providing electrical stimulation to the arteries, veins, nerves innervating the arteries or veins, or walls of the organ. The apparatus has at least one electrode operably connected to a stimulus generator and placed in electrical communication with an artery, vein, nerve, or organ wall. An electrical stimulus generator causes an electrical stimulus to be administered to the artery, vein, nerve, or wall through the at least one electrode, where the electrical stimulus is effective for preventing, treating, and/or controlling a hemorrhage.

Where an implanted reservoir for intestinal contents is formed from surgically modified intestine that has been cut along a mutual contact line of laterally adjacent sections of a bent portion of intestine and connected so that the resulting upper and lower halves of the intestine form an intestinal wall of the reservoir, the system for emptying such intestinal reservoir comprises an artificial flow control device implantable in the patient's body and adapted to control flow of the intestinal contents from said reservoir, the flow control device comprising at least one pump adapted to act on said intestinal wall so as to reduce the reservoir's volume, thereby emptying the reservoir. The system may further comprise an entry valve upstream of the reservoir and an exit valve downstream from the reservoir. The pump may be an electrical stimulation type pump, a hydraulically acting type pump or/and a mechanically acting type pump.

The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting the perception of pain while preserving other sensory and motor function, and proprioception.

A method and system for combination therapy utilizing local drug delivery and radiotherapy at a target site of body tissue are provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site of internal body tissue. A counter electrode is in electrical communication with the source electrode, and is configured to cooperate with the source electrode to form a localized electric field proximate to the target site. A cargo may be delivered to the target site when exposed to the localized electric field. Radiotherapy is applied to the target site in combination with the local drug delivery.

An ingestible medical device that includes an ingestible capsule. Within the ingestible capsule is a non-refillable drug dispenser containing a therapeutic agent. The capsule can also include a real-time clock. A controller within the capsule can be operatively connected to the drug dispenser and can include a memory module and a processor operable to execute a software application stored on the memory module to control the operation of the drug dispenser to administer the therapeutic agent according to a real-time schedule measured via the real-time clock. The ingestible medical device can also include an iontophoretic circuit or system for drug delivery as well as physiological sensors to detect the occurrence or worsening of a medical condition.