The invention features methods and devices useful for stimulating brain tissue in a subject via electrodes within cranial bone. These methods and devices may be utilized for the detection, prevention, and/or treatment of neurological disorders via electric stimulation. Additionally, the methods and devices disclosed herein may be useful for the treatment, inhibition, and/or arrestment of the growth of tumors.

An implantable neural interface system comprising: at least one electrode; a spine providing a passage for electrical conductors connectable to a pulse generator and the at least one electrode; at least one arm extending from the spine, wherein the electrode is positioned on the arm; and a strain relief feature configured to reduce strain in relative movement of portions of neural interface system to accommodate a curvature in an axis of a target on or in which the neural interface is provided.

An implantable nerve stimulator is implanted in a patient near a nerve target. The implantable nerve stimulator has a plurality of electrodes through which stimulation is provided to the nerve target. The relative location of the nerve target and the electrodes may be determined by applying stimulation to the nerves via each of the electrodes, determining an effect of the stimulation for each of the electrodes, and mapping a location of the nerve relative to the electrodes based on the effect of the stimulation for each of the electrodes.

A medical robot system, including a robot coupled to an effectuator element with the robot configured for controlled movement and positioning. The system may include a transmitter configured to emit one or more signals, and the transmitter is coupled to an instrument coupled to the effectuator element. The system may further include a motor assembly coupled to the robot and a plurality of receivers configured to receive the one or more signals emitted by the transmitter. A control unit is coupled to the motor assembly and the plurality of receivers, and the control unit is configured to supply one or more instruction signals to the motor assembly. The instruction signals can be configured to cause the motor assembly to selectively move the effectuator element.

Methods, systems and devices for treating chronic pain by inducing stimulation to a predetermined region of the brain and measuring neural activity response to the stimulation and evaluating a neuroplasticity and/or excitability of neural-structures in a predetermined brain region, then stimulating the predetermined brain region to treat the chronic pain.

Devices and methods for manipulating devices such as micro-scale devices are provided. The devices can include a tether of various materials surrounded by a stiff body. The tether interfaces with microscale devices to draw them against the stiff body, holding the microscale devices in a locked position for insertion into or extraction out of tissue. The tensional hook and stiff body are configurable in a multitude of positions and geometries to provide increased engagement. Such configurations allow for a range of implantation and extraction surgical procedures for the device within research and clinical settings.

The present disclose generally relates to systems and methods for active titration of one or more cranial or peripheral nerve stimulators to treat obstructive sleep apnea. The active titration can be accomplished in an automated fashion by a closed-loop process. The closed-loop process can be executed by a computing device that includes a non-transitory memory storing instructions and a processor to execute the instructions to perform operations. The operations can include defining initial parameters for the one or more cranial or peripheral nerve stimulators for a patient; receiving sensor data from sensors associated with the patient based on a stimulation with the one or more cranial or peripheral stimulators programmed according to the initial parameters; and adjusting the initial parameters based on the sensor data.

An apparatus and method is provided for intraoperative tissue stimulation during port-based surgery. The apparatus includes an access port and electrical terminals attached to the access port for tissue stimulation. In an alternative embodiment, the apparatus may include an access port, with or without electrical terminals attached to the access port for tissue stimulation, and electrocorticography sensors attached to the access port. The method includes inserting an access port into a tissue, applying an electrical potential to the tissue using electrical terminals attached to the access port, and measuring consequent neural activity using electrocorticography sensors attached to the access port.

A universal implantable integrated circuit medical device platform having integral and monolithic circuit traces. The platform allows for implanting into a mammalian body single and multi-functional interface devices for sensing, monitoring stimulating and/or modulating physiological conditions within the body. Microelectronic circuitry may be integrated onto the platform or may be joined as modular components to the platform.

Provided are a method, server, and computer program for designing a customized headgear for transcranial direct current stimulation. According to one embodiment, there is provided a method for designing a customized headgear for transcranial direct current stimulation performed by a computing device and applying electrical stimulation to a preset target point in a brain of a subject, the method including: acquiring a head image of the subject; generating a headgear mask by using the acquired head image; generating a stimulator mask by using an optimal stimulation position combination for applying the electrical stimulation to the preset target point; and generating a customized headgear mask for the subject by performing a subtraction operation between the generated headgear mask and the generated stimulator mask.