A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity.

Wirelessly networked systems of implantable and non-implantable medical devices with networking protocols, software, and hardware that allow for communications and energy transfer between different the medical devices (free standing, implants and wearables) using ultrasonic waves. The networks and methods of use are used to construct cardiac pacing, deep brain stimulation, and neurostimulation networks based on ultrasonic wide band technology.

One aspect is a process for producing a segmented electrode, including providing a pipe made of metal having an outer side and an inner side, wherein the inner side of the pipe forms a hollow space. A support structure is arranged in the hollow space, so that the support structure mechanically stabilizes the pipe. Intermediate spaces are formed in the pipe, which define a plurality of segments in the pipe. An electrically insulating material is introduced into the intermediate spaces and thus forming electrically insulating areas, wherein a boundary layer is in each case defined between the segments and the areas. The pipe is cut so that several segmented ring-shaped electrodes are formed therefrom. The support structure is removed from the pipe.

A system and method for selecting leadwire stimulation parameters includes a processor iteratively performing, for each of a plurality of values for a particular stimulation parameter, each value corresponding to a respective current field: (a) shifting the current field longitudinally and/or rotationally to a respective plurality of locations about the leadwire; and (b) for each of the respective plurality of locations, obtaining clinical effect information regarding a respective stimulation of the patient tissue produced by the respective current field at the respective location; and displaying a graph plotting the clinical effect information against values for the particular stimulation parameter and locations about the leadwire, and/or based on the obtained clinical effect information, identifying an optimal combination of a selected value for the particular stimulation parameter and selected location about the leadwire at which to perform a stimulation using the selected value.

Devices, systems, and techniques are disclosed for determining spatial relationships between electrodes implanted within a patient. In one example, a medical device delivers, via a first electrode, an electrical stimulus and senses, for each other electrode, a respective electrical signal indicative of the electrical stimulus. The medical device determines, for each other electrode, a respective value for each respective electrical signal. The medical device determines, based on the respective values for each respective electrical signal and values of tissue conductivity of tissues of the patient interposed between the first electrode and the other electrodes, spatial relationships between the first electrode and each other electrode of the plurality of electrodes.

Systems and methods for ruggedized neural probes are provided. Such probes may be adapted for penetrating tissue. An exemplary ruggedized penetrating electrode array system includes an elongate shank having one or more electrodes disposed on at least one exterior surface thereof and a backend structure. A proximal end of the elongate shank is secured to the backend structure. The exemplary array system further includes an elongate carrier secured to the backend structure and extending away from the backend structure toward the distal end of the elongate shank, the elongate carrier being more rigid than the elongate shank. Methods for fabricating such an array system are also provided.

A charging energy control system includes an implantable medical device (IMD) and an external charger for effectuating wireless power transfer. The IMD receives charging energy to recharge a battery during an ON period and rejects the charging energy during an OFF period. A series switch is disposed between the IMD's coil and rectifier circuitry that is controlled by voltage regulation circuitry operative to generate a clamp control signal configured to detune the coil in the OFF state.

A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead.

In some examples, a method including detecting, via processing circuitry, an induced voltage in at least one of an electrode or a lead conductor of an implantable medical device, wherein the induced voltage is induced in the at least one of the electrode or the lead conductor of the implantable medical device by a radio frequency (RF) field generated by a magnetic resonance imaging (MRI) scanner; and modifying, via the processing circuitry, an MRI scan based on the detected induced voltage.

A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon's perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.