A trans mucosal neuromuscular electrical stimulation device including a mouthpiece, electrodes associated with the mouthpiece. The device and/or mouthpiece incorporates electrical circuitry operatively connecting to the electrodes to a power source and is configured to provide, in use, electrical stimulation to one or more palate and/or tongue muscles via the electrodes through the oral mucosa. The treatment regime, including the location of stimulation and the parameters used, is designed to increase resting muscle tone and/or muscle tone during sleep.

The disclosed subject matter is directed to a surgical implant and a device for its activation. The surgical implant comprises a substantially planar central body portion having a top side and a bottom side and at least two adjustable wing portions. In addition, the implant comprises at least two connecting members, each one of the at least two connecting members extending from opposite sides of the central body portion, the each one of the at least two connecting members being configured for flexibly connecting each one of the at least two wing portions at opposite sides to said central body portion.

Apnea events may be detected based on a primary biomarker, e.g., respiration, in the one or more physiological signals. The apnea events may be characterized as one of an obstructive sleep apnea (OSA) event, a central sleep apnea (CSA) event, or a combination OSA/CSA event based on a secondary biomarker, e.g., a frequency spectrum or a morphology of the respirations in the one or more physiological signals. A first electrical stimulation may be provided to treat OSA in response to a first one or more of the apnea events being characterized as OSA events. A second electrical stimulation may be provided to treat CSA in response to a second one or more of apnea events being characterized as CSA events. A third electrical stimulation may be provided to treat combination OSA/CSA in response to a third one or more of the apnea events being characterized as combination OSA/CSA events.

Medical devices and methods of medical treatment for the electrical stimulation of target nerves to enhance waste clearance in the brain for treating neurological disorders such as Alzheimer's disease (AD), including prodromal, mild cognitive impairment (MCI) and early stage Alzheimer's disease.

Devices for treating obstructive sleep apnea include appliances for securing to one or more teeth of a patient and connected to a lingual bridge configured to change shape and apply pressure to a patient's tongue, preventing backward movement of the tongue and blockage of the patient's airway. The lingual bridge is composed of a shape memory alloy to allow the bridge to change shape once deployed in a patient's oral cavity and exposed to increased temperature in the patient's mouth. Pulse generators and electrodes are included to electrically stimulate the nerves and muscles of the tongue to assist in keeping the tongue from moving backward in the mouth during sleep.

A sensory unit for implant-supported dental implants or prostheses. The main unit is composed of two or more subunits, or devices. One of the units is placed in the region of the implant head, and will have the function of transforming the mechanical forces into an electrical signal. It can also be placed in the masticatory region of implant supported bridges or overdenture, to perform the same function, i.e., transforming mechanical loads into an electrical signal. A second unit, will receive by a wired or wireless electronic communication the electrical signal, and will convert it into a neurological stimulus perceived sensorially by the sensory endings of the trigeminal nerve, unilaterally, or bilaterally. This second unit will be arranged in the submucosa, in the vicinity of the nerve ending, taking advantage of the anatomical depressions or recesses in the region, and will establish a gradient of neurological stimulation towards the nerve ending.

An electric field generating device for oral care of the present invention includes: at least one electrode configured to receive a driving signal and generate an electric field corresponding to the driving signal; and a signal supply part configured to generate the driving signal by mixing an AC signal and a DC signal and supply the driving signal to an electrode.

Provided is a mouthpiece which is mounted in an oral cavity for use in changing the shape of the skull including the maxillary bone and is composed of a plurality of segment pieces, at least some of the segment pieces being configured to approach or be spaced apart from each other by means of a screw, wherein the surfaces of the segment pieces facing or contacting the skin in the oral cavity are configured such that the segment pieces overlap with each other, such that a gap does not occur in spite of the approaching or spacing-apart movement of the segment pieces relative to each other.

Intraoral appliances are disclosed that provide electrical stimulation to tissue in a patient's oral cavity in a manner that reduces apnea events during sleep. A representative appliance can induce a current or currents through tissue and/or anatomical structures in a manner that maintains upper airway tone and/or patency.

An example method includes receiving one or more physiological signals; detecting an apnea event based on the one or more physiological signals; determining that the apnea event cannot be characterized as one of a normal, OSA (obstructive sleep apnea), CSA (central sleep apnea), or combination OSA/CSA event; and outputting an electrical stimulation as a default based on determining that the apnea event cannot be characterized as a normal event, an OSA event, a CSA event, or combination OSA/CSA events.