A system and related method for eliminating microbes from a metal orthopedic appliance includes a counter electrode and working electrode used for applying treatment, and a reference electrode used for monitoring safety parameters. The working electrode is the implanted appliance. Electrical current is applied between the counter electrode and the working electrode to create electrochemical current through the system and create electrochemical reactions on the surface of the working and counter electrode. The chemical species created at the working electrode provide a mechanism to disrupt and kill microbes on that surface, including bacterial biofilms commonly found on infected orthopedic implants. Circuitry connected to the electrodes keeps the applied current constant and allows the voltage between the working and counter electrode to vary. The reference electrode monitors the voltage at the working electrode in order to provide feedback to a processor as part of a feedback mechanism. The processor is programmed with software logic, preventing the voltage from drifting to ranges that correlate with metal immunity or corrosion regions by limiting or altering the applied current.

A system and related method for eliminating microbes from a metal orthopedic appliance includes a counter electrode and working electrode used for applying treatment, and a reference electrode used for monitoring safety parameters. The working electrode is the implanted appliance. Electrical current is applied between the counter electrode and the working electrode to create electrochemical current through the system and create electrochemical reactions on the surface of the working and counter electrode. The chemical species created at the working electrode provide a mechanism to disrupt and kill microbes on that surface, including bacterial biofilms commonly found on infected orthopedic implants. Circuitry connected to the electrodes keeps the applied current constant and allows the voltage between the working and counter electrode to vary. The reference electrode monitors the voltage at the working electrode in order to provide feedback to a processor as part of a feedback mechanism. The processor is programmed with software logic, preventing the voltage from drifting to ranges that correlate with metal immunity or corrosion regions by limiting or altering the applied current.

The invention features methods and devices useful for stimulating brain tissue in a subject via electrodes within cranial bone. These methods and devices may be utilized for the detection, prevention, and/or treatment of neurological disorders via electric stimulation. Additionally, the methods and devices disclosed herein may be useful for the treatment, inhibition, and/or arrestment of the growth of tumors.

The invention features methods and devices useful for stimulating brain tissue in a subject via electrodes within cranial bone. These methods and devices may be utilized for the detection, prevention, and/or treatment of neurological disorders via electric stimulation. Additionally, the methods and devices disclosed herein may be useful for the treatment, inhibition, and/or arrestment of the growth of tumors.

A brain stimulation simulation system and method according to a preset guide system using an anonymized data-based external server are provided. According to various embodiments of the present invention, provided is a brain stimulation simulation method according to a preset guide system using an external server, the method performed by a computing device, the method including: a first server generating a global matrix for performing brain stimulation simulation on a plurality of objects by using a plurality of brain models for each of the plurality of objects; and a second server being provided with the generated global matrix from the first server and performing the brain stimulation simulation on the plurality of objects by using the provided global matrix.

The present invention relates to an artificial joint comprising a first joint portion (101), a second joint portion (105) and an intermediate portion (103). The first joint portion and the second joint portion each comprise an electrically conductive material and the intermediate portion comprises a non-conductive material and is arranged in between the first joint portion and the second joint portion such that the first joint portion is electrically isolated from the second joint portion. The artificial joint further comprises an internal electronic unit (110) provided inside of the isolating portion being connected to the first joint portion via at least one first electrode (111) and to the second joint portion via at least one second electrode (113). Thus, a first voltage can be applied to the first joint portion and a second electric voltage can be applied to the second joint portion, the voltages being with reference to a common reference potential.

The present invention provides for the intratumoral delivery of immunomodulators. In particular, it provides delivery of co-stimulatory molecules using intratumoral electroporation. The present invention provides a method for the treatment of malignancies, wherein the administration of a plasmid encoding for a therapeutic costimulatory protein, in combination with electroporation has a therapeutic effect on primary tumors as well as distant tumors and metastases.

The present invention provides for the intratumoral delivery of immunomodulators. In particular, it provides delivery of co-stimulatory molecules using intratumoral electroporation. The present invention provides a method for the treatment of malignancies, wherein the administration of a plasmid encoding for a therapeutic costimulatory protein, in combination with electroporation has a therapeutic effect on primary tumors as well as distant tumors and metastases.

Methods, systems and devices for treating chronic pain by inducing stimulation to a predetermined region of the brain and measuring neural activity response to the stimulation and evaluating a neuroplasticity and/or excitability of neural-structures in a predetermined brain region, then stimulating the predetermined brain region to treat the chronic pain.

Methods, systems and devices for treating chronic pain by inducing stimulation to a predetermined region of the brain and measuring neural activity response to the stimulation and evaluating a neuroplasticity and/or excitability of neural-structures in a predetermined brain region, then stimulating the predetermined brain region to treat the chronic pain.