A device for reducing foreign body response in a subject caused by an electrode implanted in a subject's tissue. A base is secured to the subject, having a base aperture in proximity to the target site. The base can receive and align a body thereon. A body contains a chamber extending between a chamber aperture, aligned with the base aperture, at one end and a chamber opening at an opposite end. The chamber contains an acoustic coupling medium, such as polyvinyl alcohol cryogel, transmits acoustic vibrations from a transducer without altering their frequency. The transducer is mounted to the device and is configured to transmit acoustic vibrations into the chamber and through said acoustic coupling medium to the subject tissue at the target site, creating an acoustic field in the target site sufficient to reduce foreign body response in the subject where the electrode contacts the target tissue.

Devices, systems, and techniques for controlling electrical stimulation therapy are described. In one example, a system is configured to deliver, via a first electrode combination, a first stimulation pulse to a portion of a spinal cord of a patient located caudally of a spinal cord injury location of the spinal cord of the patient; sense, via a second electrode combination, an evoked compound action potential (ECAP) signal elicited by the first stimulation pulse; identify, by processing circuitry, a characteristic of the ECAP signal; determine, by the processing circuitry and based on the characteristic of the ECAP signal, a therapy parameter value that at least partially defines a second stimulation pulse; and deliver the second stimulation pulse according to the determined therapy parameter value.

The present invention relates to a control system for a movement reconstruction and/or restoration system for a patient, comprising a movement model generation module to generate movement model data information, an analysis module receiving and processing data provided at least by the movement model generation module, wherein the control system is configured and arranged to prepare and provide on the basis of data received by the movement model generation module and the analysis module a movement model describing the movement of a patient and providing, on the basis of the movement model, stimulation data for movement reconstruction and/or restoration.

This application is generally related to systems and methods for providing a medical therapy to a patient by tracking patient activity and adjusting medical therapy based on occurrence of different types of activities performed by the patient including user indicated activities inputted from an icon driven user interface of an external patient controller device.

A mobility augmentation system assists a user's movement by determining a corresponding electrical stimulation for the movement. A wearable stimulation array includes sensors, electrodes, an electrode multiplexer, and a controller that executes the mobility augmentation system. The sensors measure movement data, and the mobility augmentation system applies a movement model to the measured movement data. The model can determine different electrical actuation instructions depending on the movement stimulated. For example, to stimulate a knee flexion, the movement model output enables a first set of the electrodes to operate as cathodes and a second set of electrodes to operate as anodes. To stimulate a knee extension, the first set of electrodes can be enabled to operate as anodes and a third set of electrodes as cathodes. The user can provide feedback of the applied stimulation, which the system can use to retrain the model and optimize the stimulation to the user.

A flexible sheet for neurostimulation has a flexible non-conductive substrate matrix in which electrodes are embedded along a lower surface. Electrically conductive wires extend from the electrodes through the flexible substrate to another exterior surface of the substrate. Methods of making the flexible sheet and making a device using the flexible sheet are also disclosed.

Techniques for modeling therapy fields for therapy delivered by medical devices are described. Each therapy field model is based on a set of therapy parameters and represents where therapy will propagate from the therapy system delivering therapy according to the set of therapy parameters. Therapy field models may be useful in guiding the modification of therapy parameters. As one example, a processor compares an algorithmic model of a therapy field to a reference therapy field and adjusts at least one therapy parameter based on the comparison. As another example, a processor adjusts at least one therapy parameter to increase an operating efficiency of the therapy system while substantially maintaining the modeled therapy field.

A system and method for restoring inspiratory muscle function to restore breathing and expiratory muscle function to restore an effective cough in the same individual, wherein the systems that selectively activate the inspiratory or expiratory muscle function are separately ground to limit or prevent the flow of electrical current to both the expiratory and inspiratory muscles at the same time and to avoid damaging either neuromuscular system. Also described is the method by which the inspiratory or expiratory muscles are activated selectively to optimize the action of the inspiratory muscles to restore breathing and to optimize the action of the expiratory muscles to restore cough.

A garment is wearable on an anatomical region and includes electrodes contacting the anatomical region when the garment is worn on the anatomical region. An electronic controller is configured to detect electromyography (EMG) signals as a function of anatomical location and time using the electrodes, and identify tremors as a function of anatomical location and time based on the EMG signals.

A method of controlling a movement of a hybrid robot including a locomotion stimulation device carried by an animal includes monitoring, via a positioning component the locomotion stimulation device, a position and an orientation of the hybrid robot; providing, via a stimulator of the locomotion stimulation device, a stimulus to the animal based on an angular difference between the orientation with respect to a direct path from the position to a predetermined destination to control the movement of the hybrid robot; monitoring, via the positioning component, one or a combination of a displacement, a velocity or an acceleration of the hybrid robot in response to the stimulus; ceasing provision of the stimulus to the animal in response to the one or the combination of the displacement, the velocity or the acceleration being below a corresponding pre-defined minimum so as to allow the animal to roam freely.