Methods, implantable devices, and systems for treating a cancer or inhibiting cancer growth or recurrence in a subject are described herein. Such methods can include electrically stimulating a thoracic splanchnic nerve (such as a greater splanchnic nerve) of the subject with a plurality of electrical pulses emitted from one or more electrodes m electrical communication with the splanchnic nerve, wherein the plurality of electrical pulses triggers one or more action potentials in the splanchnic nerve to increase circulating natural killer (NK) cells in the subject. An implantable device may include one or more electrodes configured to be in electrical communication with a thoracic splanchnic nerve of a subject with cancer, and be configured to operate the one or more electrodes to electrically stimulate the splanchnic nerve with a plurality of electrical pulses that triggers one or more action potentials in the splanchnic nerve that increase circulating NK cells.

Apnea events may be detected based on a primary biomarker, e.g., respiration, in the one or more physiological signals. The apnea events may be characterized as one of an obstructive sleep apnea (OSA) event, a central sleep apnea (CSA) event, or a combination OSA/CSA event based on a secondary biomarker, e.g., a frequency spectrum or a morphology of the respirations in the one or more physiological signals. A first electrical stimulation may be provided to treat OSA in response to a first one or more of the apnea events being characterized as OSA events. A second electrical stimulation may be provided to treat CSA in response to a second one or more of apnea events being characterized as CSA events. A third electrical stimulation may be provided to treat combination OSA/CSA in response to a third one or more of the apnea events being characterized as combination OSA/CSA events.

The present specification discloses devices and methodologies for the treatment of GERD. Individuals with GERD may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow, have improved energy storage requirements, enable improved LES function while concurrently delivering additional health benefits, and enable improved LES function post stimulation termination.

A method for estimating an offset between a first group and a second group of contacts with respect to a longitudinal direction. Each group of contacts includes a plurality of electrodes arranged along a surface of a body of a lead. The method includes the steps of: (a) Selecting a number of electrode pairs, each electrode pair including an electrode of the first contact group and an electrode of the second contact group, and measuring the impedances between the electrodes of each selected electrode pair; (b) pre-conditioning the measured impedances for attenuating unwanted noise to generate pre-conditioned impedances, and (c) determining the lead offset using the pre-conditioned impedances.

A method, system, and apparatus for temporarily modifying an impedance of a neural stimulator. The apparatus includes an antenna comprising a first pole and a second pole, a switching circuit configured to output switched signals, a rectifier configured to receive switched signals from the switching circuit, a plurality of electrodes, and a controller, wherein the switching circuit, based on the control signal, modifies one or more of a first pole signal or a second pole signal. The impedance may be modified via one or more switches in a switching circuit of the neural stimulator. The impedance change may be sensed by an external circuit. Also, an electrode-tissue impedance of the neural stimulator may be determined and an impedance of an external circuit modified based on the electrode-tissue impedance of the neural stimulator.

An example method includes receiving one or more physiological signals; detecting an apnea event based on the one or more physiological signals; determining that the apnea event cannot be characterized as one of a normal, OSA (obstructive sleep apnea), CSA (central sleep apnea), or combination OSA/CSA event; and outputting an electrical stimulation as a default based on determining that the apnea event cannot be characterized as a normal event, an OSA event, a CSA event, or combination OSA/CSA events.

An Example of a system for providing a patient with pain management may include a sleep monitoring circuit, a pain relief device, and a control circuit. The sleep monitoring circuit may be configured to sense one or more sleep signals from the patient and to determine a sleep state of the patient using the one or more sleep signals. The one or more sleep signals may include one or more physiological signals corresponding to the sleep state of the patient. The pain relief device may be configured to deliver one or more pain relief therapies. The control circuit may be configured to control the delivery of the one or more pain relief therapies using therapy parameters and to adjust the therapy parameters based on the determined sleep state.

A method for assisting and tracking a user with a neurological disorder includes receiving, from a user interface, a selection of a physical activity that the user wishes to perform. The method further includes sending a control signal to a neurostimulation device, the control signal including instructions for the neurostimulation device to implement a neurostimulation therapy regimen corresponding to the selected physical activity that the user wishes to perform. The method also includes receiving an activity feedback signal from at least one sensor, the activity feedback signal including information regarding performance of the selected physical activity when performed by the user. The method further includes sending a monitoring signal to a remotely located caregiver device, the monitoring signal including activity data derived from the information regarding performance of the selected physical activity.

The present invention relates to systems and methods for planning and/or providing neuromodulation. An example system includes a first data input module for stimulation related basic data, a second data input module for stimulation related response data, a transfer module configured and arranged such that the stimulation related basic data received by the data input module are linked and/or translated into and/or with the response data and/or artificial response data created by the transfer module, wherein the data generated by the transfer module are transfer data, the transfer data comprising link data and/or translation data and/or artificial response data, and a mapping module configured and arranged such that based on the stimulation related basic data and stimulation related response data and the transfer data a digital characteristic map is generated, which describes an interrelation between the stimulation related basic data and the stimulation related response data and the transfer data.

The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting the perception of pain while preserving other sensory and motor function, and proprioception.