A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity.

Apparatuses and methods are disclosed for efficient wireless powering of an electrical load with precise external control over pulsed voltage waveform and metering of charge delivered. The system interfaces to an inductive coil for RF power delivery from an external duty-cycled RF power transmitter, and the electrical load. The electrical load may be a photosensitive array of electrodes for an optically addressed, electrically activated retinal prosthesis. The voltage waveform to activate the load is controlled by the transmitted RF amplitude, including switching between cathodic and anodic phases of electrical stimulation. Charge delivered to the load is quantified as discharge events through a series capacitor, transmitted by backtelemetry to the receiver for continuous monitoring throughout the stimulation phases. The subject disclosure further provides for calibration of voltage amplitude and charge metering, to compensate for variable wireless link and load conditions, through additional stimulation phases with a supplementary load with known and stable characteristics.

A trial stimulation system includes a trial electrical stimulator. Additionally, systems for securing a disposable trial stimulator to the body of a patient are described, which may function to improve the durability of the system during the trial period and reduce the risk of damage or malfunction to the system due to lead/electrode dislocation and/or off-label uses like showering or bathing with the trial stimulator still secured to the body.

This application is generally related to systems and methods for providing a medical therapy to a patient by tracking patient activity and adjusting medical therapy based on occurrence of different types of activities performed by the patient including user indicated activities inputted from an icon driven user interface of an external patient controller device.

A method and apparatus for treatment of heart failure by increasing secretion of endogenous naturetic hormones ANP and BNP such as by stimulation of the heart atria. Heart pacing is done at an atrial contraction rate that is increased and can be higher than the ventricular contraction rate. Pacing may include mechanical distension of the right atrial appendage. An implantable device is used to periodically cyclically stretch the walls of the appendage with an implanted balloon.

Delivery devices, systems, and methods for delivering implantable leadless pacing devices are disclosed. An example delivery device may include an outer tubular member including a lumen extending from a proximal end to a distal end thereof and an intermediate tubular member including a lumen extending from a proximal end to a distal end thereof. A distal holding section may be coupled to the intermediate tubular member and define a cavity therein for receiving a proximal implantable leadless pacing device and a distal implantable leadless pacing device in a linear arrangement. The distal holding section may have a proximal body portion and a distal body portion. The proximal body portion may be more flexible than the distal body portion. An inner tubular member including a lumen extending from a proximal end to a distal end thereof may be slidably disposed within the lumen of the intermediate tubular member.

An example of a system for programming neurostimulation according to a stimulation configuration may include stimulation configuration circuitry, volume definition circuitry, stimulation effect circuitry, and recording circuitry. The stimulation configuration circuitry may be configured to determine the stimulation configuration. The volume definition circuitry may be configured to determine stimulation field model(s) (SFM(s)) each representing a volume of tissue activated by the neurostimulation. The stimulation effect circuitry may be configured to determine a stimulation effect type for each tagging point specified for the SFM(s) and to tag the SFM(s) at each tagging point with the stimulation effect type determined for that tagging point. The stimulation effect type for each tagging point is a type of stimulation resulting from the neurostimulation as measured at that tagging point. The recording circuitry may be configured to generate SFM data representing the determined SFM(s) with the stimulation effect type tagged at each tagging point.

Embodiments presented herein are generally directed to techniques for separately transferring power and data from an external device to an implantable component of a partially or fully implantable medical device. The separated power and data transfer techniques use a single external coil and a single implantable coil. The external coil is part of an external resonant circuit, while the implantable coil is part of an implantable resonant circuit. The external coil is configured to transcutaneously transfer power and data to the implantable coil using separate (different) power and data time slots. At least one of the external or internal resonant circuit is substantially more damped during the data time slot than during the power time slot.

An implantable medical device (IMD) and method are provided. The IMD includes a sensing channel configured to obtain biological signals indicative of biological behavior of an anatomy of interest over a period of time. The biological behavior has a feature of interest that repeats over time. The biological signals have clinically relevant (CR) segments that include information related to the feature of interest. The biological signals have non-clinically relevant (NCR) segments that do not include information related to the feature of interest. At least one of circuitry or a processor are configured to compare the biological signals to an amplitude window to distinguish the CR segments from the NCR segments, save to memory the CR segments and delete the NCR segments, save to memory time information indicative of a duration of the NCR segments that were deleted and to form a lossy compressed data set for the biological signals.

Techniques are described for providing a therapeutic pseudo-constant DC current in an implantable stimulator using pulses whose positive and negative phases are not charge balanced. Such charge imbalanced pulses act to charge any capacitance in the current path between selected electrode nodes, such as the DC-blocking capacitors and/or any inherent capacitance such as those present at the electrode/tissue interface. These charged capacitances act during quiet periods between the pulses to induce a pseudo-constant DC current. Beneficially, these DC currents can be small enough to stay within charge density limits and hence not corrode the electrode or cause tissue damage, and further can be controlled to stay within such limits or for other reasons. Graphical user interface (GUI) aspects for generating the charge imbalanced pulses and for determining and/or controlling the pseudo-constant DC current are also provided.