A method and system capable of applying microwave therapy guided by thermoacoustic imaging and/or thermoacoustic thermometry is disclosed. The system includes a thermoacoustic imaging system and/or a thermoacoustic thermometry system that generate(s) a map of a region of interest; and a microwave therapy system that targets the region of interest using the map, and that applies the microwave therapy to the targeted region of interest. Treatment of the targeted region of interest may be employed by the microwave therapy system using real-time feedback from the thermoacoustic imaging system and/or the thermoacoustic thermometry system. Imaging and therapy may be automatically co-registered.

The invention relates to medical therapy of detrimental lesions. A system treats with non-invasive arrays of non-ionizing energy-radiation sources. The external sources focus energy dose distribution to a selected volume in a body. Energy output is directed towards a pathologic location and quenched around other sites or healthy tissue. Beam aiming is done without source movement. Targeted, volumetrically discrete energy deposition can beneficially manipulate lesions within the body. The purpose of the focused and enhanced energy deposition is to repair or disable pathologic physiology or structures, nerve pathways, extracellular fluid, and misfolded proteins. Locally augmented energy is used to enhance immunity, release pharmaceutical compounds from energy-sensitive vesicles and reconfigure or eliminate misfolded proteins and their aggregates. Targeted tissue may have enhanced sensitivity to received energy via a non-ionizing-radiation, treatment-localizing agent. This system optimizes delivery of non-ionizing, non-ablating electromagnetic or mechanical energy, degrading or repairing an abnormality upon interaction with it.

Provided are a heat treatment device and a method and apparatus for detecting an abnormality in the heat treatment. The heat treatment device includes a radio wave signal generator configured to generate target radio wave signals for heat treatment, a radio wave signal transmitter which includes an antenna configured to transmit the target radio wave signals to a body, a radio wave signal detector configured to detect the target radio wave signals from the antenna, a ratio information determiner configured to determine ratio information about a signal phase and a signal strength by comparing a reference target radio wave signal included in the detected target radio wave signals and each of the other target radio wave signals, and an abnormality occurrence determiner configured to determine whether an abnormality occurs in the heat treatment device based on the determined ratio information and predefined reference ratio information.

This application provides a physical targeted hyperthermia system used for tumor therapy and a control method thereof. The system mainly includes a hyperthermia apparatus body, a microwave radiation device, a microwave receiving device, a microwave imaging unit, a microwave temperature-measuring unit, a hyperthermia solution generating unit, a hyperthermia solution executing unit, and a hyperthermia control device. The hyperthermia apparatus body is used to provide stable supporting surface for a patient and to provide an mounting sites for related function devices, the microwave radiation device is used to generate a microwave with a set wavelength and a set frequency radiating toward a set direction, the microwave receiving device and the microwave imaging unit are used to accurately position the tumor tissue, the hyperthermia solution generating unit is used to generate hyperthermia parameter information, and the hyperthermia solution executing unit is used to generate corresponding hyperthermia solution execution information.

This application provides a preparation method of a heating fluid used for biological targeted hyperthermia, a heating fluid preparation device, a biological targeted hyperthermia apparatus, and a control method of the biological targeted hyperthermia, in which the biological targeted hyperthermia apparatus includes: a heating fluid injection device configured to inject a heating fluid into a body circulatory system of a therapy subject; a microwave radiation device configured to provide microwave radiation with a set wavelength and a set frequency; a microwave imaging temperature-measuring device configured to detect a temperature and a position of the heating fluid in the therapy subject, and output a thermal imaging signal; and a control device used for receiving the thermal imaging signal and controlling the microwave radiation device to output the microwave radiation with the set wavelength and the set frequency.

Low power MASER (Microwave Amplification by Stimulated Emission of Radiation) radiation is used to non-invasively record molecular activity in a biological object such as a brain. Low power MASER radiation is also used to neuromodulate molecular targets via Rabi coupling, resulting for example in conformational and function change in specific molecular targets such as ligand-gated ion channels, voltage-gated ion channels, G-proteins, or dopamine receptors. The method can be used to change the energy state of targeted molecules via energization or enervation, or to ablate targeted molecules.

A phased-array MASER detector for synthetic aperture interferometric three-dimensional imaging. The detector elements, for example 10.sup.2-10.sup.6 zero bias Schottky detector diodes with sufficient sensitivity to reliably detect various values of MASER radiation, are arranged in layers offset in three dimensions. The phased-array MASER detector is particularly useful for detecting characteristics in a biological object using low energy (2-10 Watts), coherent MASER radiation. MASER intensity data of an interferometric pattern is collected by the detector array, is deconvolved, and is used to generate three-dimensional energy activity maps for a given time slice or on a time-shifting basis.

Low power MASER (Microwave Amplification by Stimulated Emission of Radiation) radiation is used to non-invasively record molecular activity in a biological object such as a brain. Low power MASER radiation is also used to neuromodulate molecular targets via Rabi coupling, resulting for example in conformational and function change in specific molecular targets such as ligand-gated ion channels, voltage-gated ion channels, G-proteins, or dopamine receptors. The method can be used to change the energy state of targeted molecules via energization or enervation, or to ablate targeted molecules.

An apparatus comprises a flexible substrate, a phased array antenna system disposed on the substrate, and a wearable applicator. The flexible substrate is configured to conform to a shape corresponding to a portion of a human body. The phased array antenna system comprises a plurality of antenna elements configured to resonate in response to an input signal and to generate a collective output electromagnetic pattern to propagate wirelessly to a target region in a human body. The wearable applicator is configured to align the collective output electromagnetic pattern with the target region.

Low power MASER (Microwave Amplification by Stimulated Emission of Radiation) radiation is used to non-invasively record molecular activity in a biological object such as a brain. Low power MASER radiation is also used to neuromodulate molecular targets via Rabi coupling, resulting for example in conformational and function change in specific molecular targets such as ligand-gated ion channels, voltage-gated ion channels, G-proteins, or dopamine receptors. The method can be used to change the energy state of targeted molecules via energization or enervation, or to ablate targeted molecules.