Systems, methods, and computer-readable media for enabling ultraviolet radiation treatments are provided.

Catheter tube capable of irradiating laser optimized in light radiation efficiency and distribution, used in photosensitization reaction treatment is provided by simple process. Catheter tubes provided to medical device inserted into a living body to irradiate target site for treatment or examination with a light to treat or examine the site. The tubes being formed of material optically having transparency, provided with insertion hole for light diffusing body, and one or more other holes different from the insertion hole, in a manner extending in longitudinal direction of catheter tubes. Inside the other holes, space is present adjacent to inner wall thereof, the inner wall forming optical interface between the material and gas phase or liquid phase in the space, which are different from each other in refractive index, to conjointly form reflection surface for adjusting radiation distribution of light emitted by light diffusing body.

Disclosed are embodiments of a method for affecting thrombi formation on an indwelling catheter. The method involves the step of providing an intravenous catheter. The intravenous catheter includes an inner surface and an outer surface, and the intravenous catheter is located within a blood vessel. A light diffusing element is inserted into the intravenous catheter. Light is emitted from the light diffusing element such that the light irradiates the intravenous catheter. The light emitted from the light diffusing element is configured to promote or hinder thrombi formation on the inner surface or outer surface of the intravenous catheter. Also disclosed are an illumination system for affecting thrombi formation on an intravenous catheter as well as an indwelling intravenous catheter system.

A stent device including a stent coated with a photosensitizer, the stent including a pair of electrodes; and a circuit fixed to the stent, the circuit including a light emitting diode, a power receiving means for wirelessly receiving power from the outside, and converting the power to electric power; a second communicating means for receiving a control command from the outside; and a second control means for applying, based on the control command, the electric power to the electrodes causing an electric current to flow through the stent between the electrodes, the flow causing heating of the stent, and for controlling a temperature of the stent to provide hyperthermia therapy to a tumor, the second control means further for applying, based on the control command, the electric power to the light emitting diode to emit a predetermined wavelength of light to the photosensitizer to provide photodynamic therapy to the tumor.

The invention relates to a device (17) for treatment of body tissue, in particular for the permanent occlusion of varicose veins, preferably in the lower limbs, of varicocele and/or of vascular malformations and/or for the use in aesthetic surgeries, preferably laser assisted lipolysis, and/or for tumor treatment by means of laser induced thermotherapy and/or photodynamic therapy, by means of a light diffuser (13) circumferentially and endoluminally irradiating said tissue by laser light energy, said diffuser (13) being connected at its proximal end to a source (10) of laser light energy via a flexible wave guide (12) comprising a fiber optic core (1) covered by an optical cladding (2) having a refractive index smaller than that of the core (1), wherein in the cladding (2) and/or in the core (1) imperfections (18) are provided, designed as recesses and adapted to direct the light, preferably to refract and/or reflect the light propagating within the core (1) and/or its optical cladding (2) in generally radial directions, wherein a cap (7) transparent to the laser light enclosing the distal end of the core (1) and its optical cladding (2) in a fluid tight and/or liquid tight manner is provided. According to the invention the device (17) is characterized in that the outer surface (19) of said optical cladding (2) is fused in the region (A) between said imperfections (18) to the inner surface (21), preferably the inner diameter, of the cap (7) and/or in that the outer surface (19) of said optical cladding (2) extending over a distance in front and/or behind the region (A) provided with the imperfections (18) is fused to the inner surface (21), preferably the inner diameter, of the cap (7).

An apparatus and methods for tissue restoration are provided. The apparatus may include a catheter shaft extending from a proximal end to a distal tip, the catheter shaft defining lumens including an inflation lumen and a light fiber lumen, a coated balloon positioned on a translucent distal segment of the catheter shaft proximal to the distal tip in fluid communication with the inflation lumen, the coated distal balloon comprising a translucent material and a coated material on an outer surface of the coated balloon, and a light fiber positioned in the catheter shaft in the light fiber lumen and extending through the translucent distal segment.

An illumination system for a medical technology therapy and/or diagnosis system is provided. The system includes a light source, an optical waveguide, and an optical element in the form of a diffuser element. The optical waveguide has a first end that is connectable or assignable to the light source and the diffuser element is arranged at a second end of the optical waveguide so that light from the optical waveguide is injected into the optical element. The optical element has a lateral surface covered by a reflector layer at least in a section thereof. The reflector layer includes a mirror layer. The optical element has a light-reflecting area covered by the reflector layer and a light-transmissive area that is free of the reflector layer. Thus, light injected into the optical element is reflected on the light-reflecting area and emitted from the light-transmissive area.

A treatment method is disclosed capable of reducing the burden on a patient and enhancing the effect of killing tumor cells. The method includes administering an antibody-photosensitive substance into a vein; inserting an endoscope from a mouth, a nose, or an anus and bringing the endoscope to a vicinity of a tumor after the administering of the antibody-photosensitive substance into the vein; placing an optical fiber into the tumor or in the vicinity of the tumor; irradiating at least one of the tumor, the vicinity of the tumor, or a regional lymph node with a first near-infrared ray by the optical fiber; and irradiating the antibody-photosensitive substance bound to a tumor cell membrane in the tumor cell with a second near-infrared ray after the irradiating with the first near-infrared ray, the second near-infrared ray having a shorter wavelength than that of the first near-infrared ray.

The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Provided are conformable light delivery devices for increasing light penetration depth and related methods. The device may comprise a microarray of tissue penetrating members, each member having a distal end and a proximal end, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member and a substrate that supports the tissue penetrating members, wherein the substrate is optionally a flexible substrate.