Four dimensional (4D) energy-field package assembly for projecting energy fields according to a 4D coordinate function. The 4D energy-field package assembly includes an energy-source system having energy sources capable of providing energy to energy locations, and energy waveguides for directing energy from the energy locations from one side of the energy waveguide to another side of the energy waveguide along energy propagation paths.

Lighting systems, methods, and devices for protecting human circadian neuroendocrine function during night use are described. Suitable lighting conditions can be provided for a working environment while protecting the circadian neuroendocrine systems of those occupying the illuminated workplace during the night. Lighting systems, methods, and devices can provide substantive attenuation of the pathologic circadian disruption in night workers. Lighting systems, methods, and devices can attenuate the specific bands of light implicated in circadian disruption. LED lighting systems, methods, and devices can provide increased intensity at a different portion of the spectrum than conventional LEDs, providing a useable white light even when unfavorable portions of the wavelength are attenuated by a notch filter. LED lighting systems, methods, and devices can switch between a daytime configuration and a night time configuration, wherein the daytime configuration provides unfiltered light and the night time configuration provides filtered light.

A deep brain stimulation transparent electrode array and a neural signal detection method using the same are proposed. The deep brain stimulation transparent electrode array includes a biocompatible dielectric substrate, a plurality of electrode sites arranged on one side of the substrate, a plurality of electrically conductive contacts arranged on the other side of the substrate, and an interconnector extended from each electrode site so as to be connected to each contact. The deep brain stimulation transparent electrode array is capable of conducting deep brain electrical stimulation and brain wave detection while minimizing image distortion in magnetic resonance imaging, and accuracy of the deep brain electrical stimulation and the brain wave detection may be increased by enhancing ability to carry electric current and minimizing the image distortion in the magnetic resonance imaging.

A photothermal treatment device includes: irradiation means that irradiates a lesion tissue in a body cavity with heating light; a thermo-endoscope including endoscopic imaging means that images the inside of the body cavity and thermographic imaging means that images a surface temperature of a tissue in the body cavity as a thermal image; and control means (control personal computer (PC)) that controls an output and an irradiation time of the irradiation means based on temperature information of the thermal image obtained from the thermographic imaging means.

An implantable light delivery device comprises: a core portion cladded in a cladding, the core portion comprising upconversion nano-particles (UCNPs) encapsulated in an encapsulation material. The implantable light delivery device may be used in treatments such as photodynamic therapy to provide an emission of light at a wavelength configured by the selection of UCNPs. The encapsulation material may comprise hydrogel and the cladding may comprise fluorinated ethylene propylene.

A theranostic laser system for light-activated drug delivery and monitoring. The system includes a light source, a light receiver and a coupler for simultaneously coupling a first optical delivery fiber to the light source for transmitting one or more first downstream light signals from the light source to the first optical delivery fiber and to the light receiver for transmitting one or more first upstream light signals from the first optical delivery fiber to the light receiver.

Devices and related methods for impinging light on tissue to induce one or more biological effects, and more particularly illumination devices and related methods for phototherapeutic light treatments in the presence of vitamins are disclosed. Biological effects may include at least one of inactivating and inhibiting growth of one or more combinations of microorganisms and pathogens, including but not limited to viruses. Phototherapeutic light treatments in the presence of vitamins may involve providing one or more vitamins in the form of a coating or film on a surface of a target tissue and irradiating the target tissue with light. By performing the phototherapeutic light treatment in the presence of vitamins, efficacy of the light treatment may be improved, thereby reducing viral loads and/or reducing doses of light received by the target tissue.

A treatment method and a treatment system capable of treating a tumor while checking a degree of destruction of tumor cells due to emission of light and improving a treatment effect. A treatment system configured to irradiate a photosensitive substance accumulated in a tumor cell of breast cancer with excitation light, and includes: an optical device including an optical fiber configured to propagate light between a proximal portion and a distal portion of the optical device, and including, at the distal portion, an irradiation unit configured to emit light outward, and a detection unit configured to detect external light. The distal portion of the optical device is configured to be inserted into a lactiferous duct from a lactiferous duct orifice.

Provided herein are biocompatible scaffolds engineered to convey growth stimulatory light to cells and augment their growth on the scaffolds both in vitro and in vivo. Also provide are methods of modifying biocompatible transparent waveguides to control delivery of light from the waveguide material.

The present invention relates to light therapy devices and related methods to treat the female genitalia and areas proximal thereto, including the vaginal cavity and vulvar regions in cisgender females or transgender females who have undergone sex reassignment, in particular for post-surgical indications, vaginal rejuvenation, or other medical conditions suitable for treatment with light therapy. The devices and methods are configured to provide a therapeutic amount of low level light therapy to a patient in need of treatment thereof.