Disclosed is a vibration stimulation device. The vibration stimulation device includes a box having a cavity, vibrators disposed in the cavity; light emitting elements disposed between the vibrators or disposed on the vibrators, an upper vibration layer configured to connect the vibrators and the light emitting elements to edges of the box on the cavity, and bumps disposed on the vibrators.

A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.

An adjustable illuminator for photodynamically diagnosing or treating a surface includes a plurality of first panels and at least one second panel. The plurality of first panels have wider widths and the at least one second panel has a narrower width. The narrower width is less than the wider widths. The illuminator further includes a plurality of light sources, each mounted to one of the plurality of first panels or the at least one second panel and configured to irradiate the surface with substantially uniform intensity visible light. The plurality of first panels and the at least one second panel are rotatably connected. The at least one second panel is connected on each side to one of the plurality of first panels. The second panel acts as a “lighted hinge” to reduce or eliminate optical dead spaces between adjacent panels when the illuminator is bent into a certain configuration.

A surgical site infection management lighting system and method that utilizes Far Ultraviolet C radiation that is safely used to eliminate or reduce surgical site infections. An integrated visible lighting system that includes far ultraviolet radiation doses that are safe for human cell exposure and patient and medical practitioner because of the designed and engineered and computer programmed for pathogen destruction at low doses. The lighting and electromagnetic radiation system provides illumination and for high visibility which provides medical staff optimal vision while performing a surgical or medical procedure. The system further uses electromagnetic radiation frequency of 1.489-1.350 PHz and other frequencies that are pre-engineering and computer programmed for each electromagnetic radiation event during a surgical or medical procedure. The system will efficiently and safely keep all doses substantially low and safe for human exposure while effectively killing and destroying pathogens.

A self-administrable system for improving athletic performance of a subject, the said system comprising: configured irradiation units comprising a first, a second, a third and a fourth configured irradiation unit, wherein: (A) said first configured irradiation unit is positioned to direct light energy to a first region of the brain comprising the OZ position of the primary visual cortex; (B) said second configured irradiation unit is positioned to direct light energy to a second region of the brain comprising the CZ position of the primary sensorimotor cortex; (C) said third configured irradiation unit is positioned to direct light energy to a third region of the brain comprising the C3 position of the primary sensorimotor cortex; and (D) said fourth configured irradiation unit is positioned to direct light energy to a fourth region of the brain comprising the C4 position of the primary sensorimotor cortex.

Embodiments of an improved photodynamic therapy device are provided. An example of the device includes an irradiation head having a first end and a surface at a second end, the surface having a radius of curvature. The device also includes a plurality of light sources disposed on the curved surface. The plurality of light sources are configured to emit light having at least one wavelength corresponding approximately to an excitation peak of at least one photosensitizer. The light emitted by the plurality of light sources is focused to a focal point based on the radius of curvature of the surface and a target surface (e.g., a corneal surface of an eye) may be positioned at the focal point for treatment.

An adjustable illuminator for photodynamically diagnosing or treating a surface includes a plurality of first panels and at least one second panel. The plurality of first panels have wider widths and the at least one second panel has a narrower width. The narrower width is less than the wider widths. The illuminator further includes a plurality of light sources, each mounted to one of the plurality of first panels or the at least one second panel and configured to irradiate the surface with substantially uniform intensity visible light. The plurality of first panels and the at least one second panel are rotatably connected. The at least one second panel is connected on each side to one of the plurality of first panels. The second panel acts as a “lighted hinge” to reduce or eliminate optical dead spaces between adjacent panels when the illuminator is bent into a certain configuration.

Systems and methods are disclosed for configuring a light integrated device, and include receiving sensed data from a first sensor, providing the sensed data from the first sensor to a machine learning model, receiving a machine learning output from the machine learning model based on the sensed data from the first sensor, the machine learning output comprising a light integrated device configuration, wherein the light integrated device configuration comprises a dual light emitting diodes (LED) setting, and configuring the light integrated device based on the light integrated device configuration.

A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.

A self-administrable apparatus for performing non-invasive neurostimulation therapy of a living mammal on-demand, said self-administrable non-invasive neurostimulation apparatus comprising: one or more configured irradiation units comprising a portable hollow casing having fixed dimensions, a sized internal spatial volume and an external surface configuration suitable for application to a body, and a controller assembly able to control on-demand delivery of light energy from said configured irradiation units into an interior part of the body in-vivo.