Lighting systems, methods, and devices for protecting human circadian neuroendocrine function during night use are described. Suitable lighting conditions can be provided for a working environment while protecting the circadian neuroendocrine systems of those occupying the illuminated workplace during the night. Lighting systems, methods, and devices can provide substantive attenuation of the pathologic circadian disruption in night workers. Lighting systems, methods, and devices can attenuate the specific bands of light implicated in circadian disruption. LED lighting systems, methods, and devices can provide increased intensity at a different portion of the spectrum than conventional LEDs, providing a useable white light even when unfavorable portions of the wavelength are attenuated by a notch filter. LED lighting systems, methods, and devices can switch between a daytime configuration and a night time configuration, wherein the daytime configuration provides unfiltered light and the night time configuration provides filtered light.

Lighting systems, methods, and devices for protecting human circadian neuroendocrine function during night use are described. Suitable lighting conditions can be provided for a working environment while protecting the circadian neuroendocrine systems of those occupying the illuminated workplace during the night. Lighting systems, methods, and devices can provide substantive attenuation of the pathologic circadian disruption in night workers. Lighting systems, methods, and devices can attenuate the specific bands of light implicated in circadian disruption. LED lighting systems, methods, and devices can provide increased intensity at a different portion of the spectrum than conventional LEDs, providing a useable white light even when unfavorable portions of the wavelength are attenuated by a notch filter. LED lighting systems, methods, and devices can switch between a daytime configuration and a night time configuration, wherein the daytime configuration provides unfiltered light and the night time configuration provides filtered light.

A therapeutic lighted catheter that can provide therapeutic light within a biological fluid passage for purposes of treatment and/or curing of materials within the passage. The catheter includes an elongated shaft having a first end and a second end positioned opposite the first end, the elongated shaft including a lumen extending substantially therebetween, and at least one light emitting element positioned within the elongated shaft. A control system is in electronic communication with the light emitting element and provides power thereto such that the powered light emitting element applies a light within the biological fluid passage for therapy and/or curing. The catheter can also include a means to apply a curable material.

Systems are provided for compact implantable multi-site optical stimulation and/or combined electrical and optical stimulation of spinal cord, brain, dorsal root ganglion, peripheral nerve, or other tissue. High-power LEDs or other light-emitting elements are provided at the site of stimulation, avoiding complex fiber optics or other means for coupling light from a distant laser along a stimulator to target tissue. Colocation of electrical stimulation contacts and light emitters allows the same tissue to be stimulated electrically and optically, at the same time or according to an alternating or other pattern of combined electrical and optical stimulation. These stimulators can be used as part of permanently implanted systems and/or as part of temporary, percutaneous stimulator systems. Optical and/or combined electrical and optical stimulation can be provided for pain relief, to encourage wound healing in nervous or non-nervous tissue, or to provide other clinical benefits.

A device, for vision training and therapy, comprises a spectacle frame including a left rim, a right rim, and a bridge connecting the left rim and the right rim, wherein the left rim and the right rim include a plurality of therapeutic light sources located along the left rim and the right rim, for providing light therapy to the eyes of a user, a longitudinal member connected with the spectacle frame, and extending away from the spectacle frame, along the line of sight of the user, wherein the longitudinal member includes a plurality of colored light sources connected by a white stripe arranged to be viewable by both eyes of the user and a controller connected with the plurality of therapeutic light sources and the plurality of colored light sources. Further, the longitudinal member is extendible through an extension mechanism attached to the spectacle frame.

A noninvasive method of reducing a user's body apparent body fat by applying a device emitting high power light having a wavelength shorter than 1065 nm externally through the skin of the patient. The device is placed on or attached to one or more areas of a patient's body. Sufficient energy, with a targeted value of 6.6 J/cm absorbed, is applied to one or more of those areas to cause a reduction in the measurement in the energized areas. The preferred methodology uses LEDs at about 532 nm and 635 nm. Targeted energy levels are a minimum of 2 W/cm for LED emissions applied every other day for a minimum of 75 seconds per exposed area; until desired amount of size reduction is achieved.

A stimulation system includes an energy source, an electronics unit with a controller, and an actuator that is coupled with the electronics unit and/or the energy source. The actuator emits electromagnetic waves for stimulation of genetically manipulated tissue. The electronics unit is disposed in a housing. The stimulation system is configured for at least temporary implantation in a human or animal body. The controller controls the stimulation of tissue in the body by way of the electromagnetic waves emitted by the actuator. A selector of the stimulation system selects the area of the said tissue for stimulation. The selector includes a masking device for masking certain areas of the tissue, so that an intensity of the stimulation for the masked areas is reduced or equal to zero.

Methods, systems, and devices for integrated photo-responsive contouring treatment are described. Methods include identifying a region of skin corresponding to a contouring treatment of the skin. The region of skin may be provided with a photo-responsive material overlying a portion of the region of the skin. Methods may include identifying one or more treatment regions overlapping the photo-responsive material. The treatment regions may be identified at least in part to apply the contouring treatment. Methods may include determining an irradiation profile for each of the one or more treatment regions to contour each respective treatment region as part of applying the contouring treatment. Methods may also include irradiating the photo-responsive material at the one or more treatment regions in accordance with the respective irradiation profiles. Irradiating the photo-responsive material may induce a localized change in shape of the photo-responsive material in the respective treatment regions.

This disclosure relates generally to medical devices, systems, and methods for activation of a photoactive agent during a medical procedure. In an aspect, a catheter system for activation of a photoactive agent may comprise a catheter comprising an elongate shaft comprising a proximal portion, a distal portion, and a first lumen extending along the elongate shaft. A first flexible circuit may be disposed about the distal portion of the elongate shaft. A plurality of first light-emitting diodes (LEDs) may be disposed along the first flexible circuit. A second flexible circuit may be disposed about the distal portion of the elongate shaft. A plurality of second LEDs may be disposed along the second flexible circuit. A control unit may be coupled to the proximal end of the elongate shaft. The communications cable may be disposed within the catheter and may electrically couple the first LEDs with the control unit.

Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material. Wherein, when the eyelid is positioned between the energy transducer and the scleral shield, the light energy from the energy transducer and the heated energy-absorbing material of the scleral shield conductively heats a target tissue region sufficiently to melt meibum within meibomian glands located within or adjacent to the target tissue region.