Methods and systems for modulation and mapping of brain tissue in a subject using an ultrasound assembly are provided. An exemplary method for modulation uses an ultrasound assembly including a housing and an ultrasound transducer joined to the housing. The method includes securing the housing to the head of the subject with the ultrasound transducer aligned with a region of the brain tissue to target the region of the brain tissue for modulating, and providing focused ultrasound at an acoustic pressure to the targeted region using the ultrasound transducer to induce cavitation proximate the targeted region. The method further includes detecting a cavitation signal magnitude from the induced cavitation corresponding to the acoustic pressure and modulating the targeted region.

An apparatus and method for automatically lysing a clot to recanalize vessels using ultrasound, with or without nanoparticles, microbubbles, thrombolytic drugs or other agents, is described herein. At least one ultrasound transducer with a specified geometry, bandwidth and/or transmit pulse characteristics can generate a more uniform 3-dimensional volume of defocused acoustic energy into a target area of the body. When an agent (such as, but not limited to, microbubbles) is used to lyse a clot, a certain level of ultrasound energy may be desired in order to effect certain actions or states of the agent. Bone attenuation may present an issue inhibiting sufficient ultrasound energy from reaching the agent in order to attain the desired agent action. The relative patient dimensions and location of the clot may also present an issue.

The disclosure describes imaging and therapy techniques comprising nanodroplets. More particularly, aspects of the disclosure relate to the use of nanodroplets to modify nanobubbles or microbubbles to provide improved imaging and/or therapeutic techniques and compositions.

Approaches for focusing an ultrasound transducer having multiple transducer elements include generating the first sonication to one or more target regions and measuring the first set of reflection signals resulting from the first sonication; based on the first set of reflection signals, determining whether a target number or a target occurrence rate of focusing events has been reached; if not, generating the second sonication at an adjusted acoustic power to the target region(s) and measuring the second set of reflection signals resulting from the second sonication; and based at least in part on the second set of reflection signals, adjusting a parameter value associated with one or more transducer elements so as to improve an ultrasound focus at the target region(s).

A therapeutic apparatus for therapeutic ultrasonic treatment of a tissue region that contains a flowing liquid has at least one ultrasonic source and a control unit for activating the ultrasonic source in order to radiate ultrasonic pulses according to a pulse parameter set into the tissue region. The therapeutic apparatus has a measuring system configured to determine a flow velocity of the liquid and a focus control system configured to move a focus region of the ultrasonic pulse relative to the tissue region over a longitudinal portion. A movement direction of the focus region therein corresponds to a flow direction of the liquid and a movement velocity of the focus region corresponds to the flow velocity.

A histotripsy device may include a headset configured to be mounted to an about a cranium of a human or animal, at least one transducer mounted to the headset and positioned such that, with the headset mounted to and about the cranium, the at least one transducer is positioned over and in contact with at least one temporal or suboccipital region of the cranium, wherein the at least one transducer is configured to emit focused radiation in at an ultrasonic frequency or frequency range, at least one processor, and at least one memory having instructions stored therein executable by the at least one processor to cause the at least one processor to activate the at least one transducer to produce at least one pulse of ultrasonic radiation having a pulse duration of 1 milliseconds or longer.

One or more devices, systems, and methods are described which together provide sonoluminescence biophysical oscillation technique(s) (SBOT(s)) that improve debilitated states of health for individuals comprising; biophysical oscillations that initiate, sustain, and/or control one or more sound emitting devices including speakers capable of providing harmonic and subharmonic sound and including music and/or individual musical notes that provide sound tracsons and one or more light emission devices including projectors that provide light wave emission traclums which are capable of imparting color changes, wherein tracsons and traclums provide auditory and visual stimuli that result in energy changes that create acoustic and tracson/traclum excitations. The tracson/traclum excitations are applied in an external manner to one or more bodies of humans and in some cases could be applied to animals.

The present disclosure is directed to fatty-acid glycerol ester derivative compounds containing a targeting bisphosphonate group. The disclosure further includes pharmaceutical or biomedical compositions comprising these compounds, and methods of using these compounds and compositions forming microbubbles. The microbubbles have affinity for metal-containing, especially calcium-containing, bodies and/or biological targets. In certain embodiments, these compositions are useful for providing targeted placement of microbubbles capable of cavitation on application of high frequency energy.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are systems and methods for acoustically coupling a histotripsy therapy system to the skin of a patient to provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

Multifunctional ultrasound systems and methods for body section registration and mapping of microbubble dynamics. A system is provided that includes one or more micromachined ultrasonic transducer arrays (MUTAs) configured to capture a high-resolution image of at least a portion of a body section using ultrasound and monitor microbubble activity during ultrasound treatment. The system includes an image registration module configured to spatially register the high-resolution image with a reference image. The system includes electronics configured to control one or more of drive signal amplitude, frequency filtering, multiplexing, and DC bias voltage. The system can be configured to control ultrasound treatment based on the monitoring of the microbubble activity during treatment.