According to an exemplary embodiment of the present disclosure, high intensity focused ultrasound device delivering high intensity focused ultrasound is disclosed. The high intensity focused ultrasound device comprising: a gripping part constituting a part of an outer housing of the high intensity focused ultrasound device and forming a grippable shape by a user; and an action part positioned at least partially on an extension line of a vertical cross-section of the gripping part and transmitting high intensity focused ultrasound generated from the high intensity focused ultrasound device to an outside.

Disclosed herein is a non-invasive treatment system using intermedium, and an exemplary treatment system is configured to output high-intensity focused ultrasound to remove bone tissue, inject an acoustically-transparent medium into a part where the bone tissue is removed to generate an intermedium, and output therapeutic ultrasound that passes through the intermedium. Accordingly, the bone tissue is removed in a non-invasive way using high-intensity focused ultrasound, and the intermedium is generated at the bone tissue removed site, to increase the penetration of therapeutic ultrasound or generate ultrasound itself, thereby improving an ultrasound treatment effect while minimizing the side effect (for example, infection of dura mater) of invasive surgery methods.

The present disclosure provides an ultrasonic transducer and a focused ultrasound treatment device. The ultrasonic transducer includes a sound generation unit and a sound emitting surface, the sound emitting surface being a spherical surface having a first notch, a second notch and a third notch, wherein one great circle of a sphere corresponding to the sound emitting surface is a main great circle, the first notch and the second notch are respectively positioned at two intersections of the spherical surface and a diameter perpendicular to the main great circle, and the third notch connects the first notch with the second notch; each cross-section of the sound emitting surface parallel to the main great circle is in a shape of an arc; and the ultrasonic wave generated by the sound generation unit is focused on a center of the sphere corresponding to the sound emitting surface.

Systems and methods are provided for ultrasound stimulation for immunomodulation treatment. Ultrasound stimulation of the spleen may be used to alter immune and thereby inflammatory responses of a subject by modulating specific biomarkers or cytokines associated with inflammation. A closed-loop or responsive ultrasound stimulation of the spleen may be implemented by tracking biomarkers in the blood that indicate when the stimulation is working. Modulation of specific cytokines and/or erythrocyte sedimentation rate may be performed in response to ultrasound stimulation in a diseased state.

Structures and methods for ultrasound treatment of neurological and psychological conditions, using energy levels which do not cause heating or cavitation. The structure includes an outer casing comprising a first material, and a disk positioned inside the outer casing. The disk comprises a second material that differs in composition from the first material and that has a higher acoustic attenuation of ultrasound energy than the first material.

Methods and systems for tuning lithotripsy frequency to target size are disclosed. In one embodiment, a lithotripsy system for comminuting a stone in a body includes: a burst wave lithotripsy (BWL) therapy transducer configured to transmit smooth ultrasound waves within a burst of ultrasound waves toward the stone; and a controller configured to determine operating frequency of the ultrasound waves of the therapy transducer. The operating frequency of the ultrasound waves is determined as:

[00001]$f=\mathrm{Const}.\frac{c}{d}$ where: d is a diameter of the stone, f is the frequency of the ultrasound waves, c is a wave speed in the stone, and Const. is a predetermined constant.

Systems and methods can include wearable, non-invasive ultrasound modalities for treating a variety of medical conditions, including but not limited to peripheral vascular disease. The modality could be therapeutic ultrasound (TUS), and be configured to promote angiogenesis within a patient via stimulation of cavitation and shear stress, among other mechanisms.

Methods of treating the skin and in particular removing pigment from a tattoo are provided. In preferred embodiments, a piezoelectric transducer is placed at a plurality of locations above the skin and focused acoustic waves at 7 MHz or more are transmitted into the skin. The focal point of the focused acoustic waves is between 0.1 mm and 5 mm below the surface of the skin. The design of the piezoelectric transducer along with the frequency of operation are carefully chosen to create points of treatment with a desired size and shape. The correct amount of energy is supplied to the points of treatment to produce a lesion of a desired size and shape. The lesions are spaced and located to effect the treatment of the skin.

An ultrasonic apparatus (100) for creating a holographic ultrasound field (1) comprises an ultrasound source device (10) being adapted for creating an ultrasound wave, and a transmission hologram device (20) having a transmission hologram (21) and an exposed acoustic emitter surface (22), said transmission hologram device (20) being acoustically coupled with the ultrasound source device (10) and being arranged for transmitting the ultrasound wave through the acoustic emitter surface (22) and creating the holographic ultrasound field in a surrounding space, wherein the acoustic emitter surface (22) is a smooth surface which do not influence the field distribution of the ultrasound wave. Furthermore, a method of creating a holographic ultrasound field in an object (3), wherein the ultrasonic apparatus (100) is used, and applications of the ultrasonic apparatus (100) are described.

Various devices related to a therapeutic ultrasound device for use during a medical procedure to cauterize tissue are disclosed. The therapeutic ultrasound device can include an inner tube assembly and an outer tube assembly. The device can further include a tissue engagement assembly that is secured to the distal end of the inner tube and the distal end of the outer tube. The tissue engagement assembly includes a plurality of transducers configured to provide therapeutic ultrasound. The device can include a housing assembly that is secured to the proximal end of the inner tube and the proximal end of the outer tube. The housing assembly can include a handle configured to actuate the inner tube relative to the outer tube to engage and disengage the tissue engagement assembly.