A medical device that includes a carrier member, one or more operative components disposed in the carrier member, an optical fiber at least partly disposed in the carrier member, and at least one fiber Bragg grating (FBG) sensor array associated with the optical fiber and disposed in the carrier member. The carrier member includes an insertion end and side walls that contact the subject's body during positioning of the carrier member in the subject's body. The at least one FBG sensor array measures contact forces at one or both of the insertion end and along the side walls of the carrier member during positioning of the carrier member in the subject's body. A multi-core optical fiber configured for use in a medical device for positioning in a subject's body is also provided. A system and method for guiding positioning of a medical device in a subject's body is also provided.

In one aspect, embodiments relate to a system for preventative dental laser treatment that ensures even irradiation of a laser beam. The system includes, a laser arrangement configured to generate the laser beam. The laser beam has one or more of a super-Gaussian energy profile and a transverse ring mode. The system also includes a focus optic. The focus optic is configured to converge the laser beam with a numerical aperture of 0.1 or less to a focal region. The system also includes a hand piece configured to direct the laser beam at a surface of a dental hard tissue. The system additionally includes a controller. The controller is configured to control one or more parameters of the laser source, such that a portion of the surface of the dental hard tissue is heated to a temperature in a range between 400° Celsius and 1300° Celsius.

Devices, systems, and methods can be used to deliver photobiomodulation therapy (PBMT) to the GI tract. For example, this document describes battery-enabled LED light source devices that can be deployed through or over an endoscope and anchored directly to the GI tract. Significant systemic effects can be produced by PBMT with application to one part of the body promoting beneficial anti-inflammatory and metabolic benefits in other remote sites promoted by enhanced mitochondrial function and mitokine signaling.

A system employing projected light upon objects or surfaces to determine a safe light wave length range of light to be emitted for treatment of the object or surface is provided. Light emitters are employed for projecting light waves upon the surfaces along with light reception components which are employed to receive reflected light wave ranges from such emitted light. Thereafter, a safe light wave range can be employed to treat or affect the object or surface.

The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., skin cancer). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody). In certain embodiments, the skin cancer is cutaneous squamous cell carcinoma or basal cell carcinoma.

Provided is a mouthpiece which is mounted in an oral cavity for use in changing the shape of the skull including the maxillary bone and is composed of a plurality of segment pieces, at least some of the segment pieces being configured to approach or be spaced apart from each other by means of a screw, wherein the surfaces of the segment pieces facing or contacting the skin in the oral cavity are configured such that the segment pieces overlap with each other, such that a gap does not occur in spite of the approaching or spacing-apart movement of the segment pieces relative to each other.

A radiation treatment device comprises a radiation source layer comprising a radiation source and a controller. The radiation source is configured to emit radiation with a wavelength in the range 822 nm to 1322 nm. In a preferred embodiment, the device configured to emit radiation with a wavelength of 1067 to 1077 nm.

Provided are a treatment apparatus and a treatment method capable of effectively treating cancer tumor cell (for example cancer in a range including at least a part of a cervix). A treatment apparatus is configured to irradiate an antibody-photosensitive substance bound to a tumor cell with excitation light, and includes: a main shaft including a distal portion and a proximal portion; a distal structure portion disposed on a distal side of the main shaft and formed to be larger than the main shaft in a radial direction of the main shaft; a distal shaft protruding from the distal structure portion toward the distal side; and at least one irradiation unit configured to emit the excitation light of the antibody-photosensitive substance from the distal shaft and the distal structure portion.

A treatment apparatus and a treatment method capable of effectively treating cancer in a range including at least a part of a cervix. A treatment apparatus is configured to irradiate an antibody-photosensitive substance accumulated in a tumor cell with excitation light, and includes: a tubular device including an elongated tubular member; and an irradiation device configured to be inserted into the tubular member. The irradiation device includes a main shaft including a distal portion and a proximal portion, a disk portion disposed on a distal side of the main shaft, a distal shaft protruding from the disk portion toward the distal side, and an irradiation unit disposed on the distal shaft and configured to emit the excitation light.

A tooth whitening kit and method of whitening teeth using the same. The method may include applying a tooth whitening composition directly to surfaces of a user's teeth, exposing the surfaces of the user's teeth to ambient air for a first period of time to form a film of the tooth whitening composition on the surfaces of the user's teeth, applying light to the surfaces of the user's teeth for a second period of time while the film of the tooth whitening composition remains on the surfaces of the user's teeth, ceasing application of the light to the surfaces of the user's teeth and leaving the film of the tooth whitening composition on the surfaces of the user's teeth for a third period of time, and removing the film of the tooth whitening composition from the surfaces of the user's teeth.