The present disclosure relates to compositions and methods of killing cells. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein, such as a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm.sup.−2. The cell is also contacted with one or more therapeutic agents (such as an anti-cancer agent), for example about 0 to 8 hours after irradiating the cell, thereby killing the cell. Also provided are methods of imaging cell killing in real time, using fluorescence lifetime imaging. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.

An anti-oxidizing agent or skin stress suppressing agent was provided with.

An anti-oxidizing agent or skin stress suppressing agent comprising a wavelength conversion substance as an active ingredient; a composition and a product comprising the anti-oxidizing agent or skin stress suppressing agent; and a method for suppressing oxidization and skin stress of skin using thereof were provided with. The present invention can exhibit a desirable effect on skin by effectively making use of ultraviolet light to suppress skin cells.

The present invention is directed to a tandem-structured bio-organic light emitting diode (bio-OLED) for photodynamic therapy, and to a photodynamic therapy device including the same to convert a red light emitted from the bio-organic light emitting diode into a near-infrared light (NIR) emission, thereby enabling the use of a PBM therapy in a wide wavelength range of 600 to 1,000 nm.

A phosphor-containing drug activator activatable from a Monte Carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a Monte Carlo derived x-ray dose distribution. A system for treating a disease in a subject in need thereof, includes the drug activator and a photoactivatable drug, one or more devices which infuse the photoactivatable drug and the activator including the pharmaceutically acceptable carrier into a diseased site in the subject; and an x-ray source which is controlled to deliver the Monte Carlo derived x-ray exposure to the subject for production of ultraviolet and visible light inside the subject to activate the photoactivatable drug and induce a persistent therapeutic response, the dose comprising a pulsed sequence of x-rays delivering from 0.5-2 Gy to the tumor.

Lighting systems, methods, and devices for protecting human circadian neuroendocrine function during night use are described. Suitable lighting conditions can be provided for a working environment while protecting the circadian neuroendocrine systems of those occupying the illuminated workplace during the night. Lighting systems, methods, and devices can provide substantive attenuation of the pathologic circadian disruption in night workers. Lighting systems, methods, and devices can attenuate the specific bands of light implicated in circadian disruption. LED lighting systems, methods, and devices can provide increased intensity at a different portion of the spectrum than conventional LEDs, providing a useable white light even when unfavorable portions of the wavelength are attenuated by a notch filter. LED lighting systems, methods, and devices can switch between a daytime configuration and a night time configuration, wherein the daytime configuration provides unfiltered light and the night time configuration provides filtered light.

A photothermal treatment device includes: irradiation means that irradiates a lesion tissue in a body cavity with heating light; a thermo-endoscope including endoscopic imaging means that images the inside of the body cavity and thermographic imaging means that images a surface temperature of a tissue in the body cavity as a thermal image; and control means (control personal computer (PC)) that controls an output and an irradiation time of the irradiation means based on temperature information of the thermal image obtained from the thermographic imaging means.

An implantable light delivery device comprises: a core portion cladded in a cladding, the core portion comprising upconversion nano-particles (UCNPs) encapsulated in an encapsulation material. The implantable light delivery device may be used in treatments such as photodynamic therapy to provide an emission of light at a wavelength configured by the selection of UCNPs. The encapsulation material may comprise hydrogel and the cladding may comprise fluorinated ethylene propylene.

A method and a system for light-activated drug delivery. An optical probe is coupled to a tissue for transmitting light signals to the tissue for actuating and/or monitoring drug delivery with a multi-phase method for drug delivery. A first light signal is transmitted through the optical probe for actuating and/or monitoring the drug delivery and a second light signal having a different wavelength is transmitted, simultaneously with the first light signal, through the optical probe for actuating and/or monitoring the drug delivery.

Various example embodiments relate to guiding a user of a medical laser device by voice based on monitored treatment data. In addition, a voice control procedure for operating the medical laser device with improved safety is provided. Improved usage of the medical laser device is enabled also in situations where there is a limited visual and physical access to control the device. An apparatus, a method, a theranostic system and a computer program are disclosed.

A theranostic laser system for light-activated drug delivery and monitoring. The system includes a light source, a light receiver and a coupler for simultaneously coupling a first optical delivery fiber to the light source for transmitting one or more first downstream light signals from the light source to the first optical delivery fiber and to the light receiver for transmitting one or more first upstream light signals from the first optical delivery fiber to the light receiver.