The invention relates to a method for determining the position of a surgical tool relative to a target volume inside an animal body according to a pre-plan comprising the steps of i) obtaining a plurality of two-dimensional images of said target volume using imaging means, each 2D-image being represented by an image data slice I(x,y,z); ii) reconstructing from said plurality of image data slices I(x,y,z) a three-dimensional image of said target volume using transformation means, said 3D-image being represented by a volumetric image data array V(x,y,z); iii) displaying said three-dimensional image of said target volume to an user using displaying means.

The present disclosure relates generally to devices, systems, and methods for diagnosis and treatment via laser-treated skin and, more particularly, to devices, systems, and methods for inducing leakage or rupture of one or more blood vessels comprising the dermis for various diagnostic and therapeutic applications. Other aspects of the present disclosure can include methods for detecting one or more target analytes in a dermis of a subject, methods for facilitating skin-to-blood delivery of agent in a subject, and methods for collecting a fluid sample from the dermis of a subject.

A microparticle for drug loading, a drug loading microparticle, a particle containing tube, and an implantation system for the microparticle. The microparticle for drug loading includes a housing (31) and a drug loading part (34) located inside the housing and is used for being implanted into body tissues by means of a puncture needle (5); the housing (31) is provided with at least one micro-hole (33) running through the wall thickness of the housing (31); and the drug loading part (34) is located inside the housing (31) and is used for loading drugs. The microparticle for drug loading/drug loading microparticle can achieve different types of drug loading and different release speeds, can be directly implanted into tissues, and have the technical advantages of both microspheres and radioactive particles.

A fastener applicator includes a body portion including a handle assembly, a cartridge assembly supported within the body portion, the cartridge assembly including implantable fasteners, a drive assembly supported within the body portion and operatively coupled to the cartridge assembly to engage the implantable fasteners, and an actuation assembly supported within the handle assembly and operatively coupled to the drive assembly to fire a distal-most implantable fastener upon actuation of the actuation assembly. At least one of the implantable fasteners includes a body including a tissue facing surface, a tissue penetrating portion extending from the body, and a capsule affixed to the tissue facing surface of the body, the capsule including radioactive material.

Carriers for embodying radioactive seeds, as well as a device for loading and customizing brachytherapy carriers based on the principles of optimizing a more precise and predictable dosimetry, and adaptable to the geometric challenges of a tumor bed in a real-time setting. The present disclosure relates to a specialized loading device designed to enable a medical team to create a radionuclide carrier for each patient and tumor reliably, reproducibly and efficiently.

An interventional therapy system may include at least one catheter configured for insertion within an object of interest (OOI); and at least one controller which configured to: obtain a reference image dataset including a plurality of image slices which form a three-dimensional image of the OOI; define restricted areas (RAs) within the reference image dataset; determine location constraints for the at least one catheter in accordance with at least one of planned catheter intersection points, a peripheral boundary of the OOI and the RAs defined in the reference dataset; determine at least one of a position and an orientation of the distal end of the at least one catheter; and/or determine a planned trajectory for the at least one catheter in accordance with the determined at least one position and orientation for the at least one catheter and the location constraints.

A method for treating a tumor, comprising identifying a tumor as a squamous cell carcinoma and implanting in the tumor identified as a squamous cell carcinoma tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon between 3.5 Mega becquerel (MBq) hour and 8 MBq hour, per centimeter length.

Described embodiments include an apparatus (20, 21), which includes a support (22), including an outer surface (24) and configured for insertion into a body of a subject. The apparatus further includes multiple atoms (26) of a radionuclide, which radioactively decays to produce a daughter radionuclide, coupled to the outer surface, and a layer (28, 33) of a polymer, which is permeable to the daughter radionuclide, that covers the atoms. Other embodiments are also described.

A method for treating a tumor, comprising identifying a tumor as a pancreatic cancer tumor and implanting in the tumor identified as a pancreatic cancer tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon between 5.6 Mega becquerel (MBq) hour and 9.5 MBq hour, per centimeter length.

A method for treating a tumor, comprising identifying a tumor as a glioblastoma tumor and implanting in the tumor identified as a glioblastoma tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon between 3.7 Mega becquerel (MBq) hour and 8.8 MBq hour, per centimeter length.