Systems and methods are disclosed for analyzing data from oncology treatments such as immune checkpoint inhibitor or radiotherapy therapies, including predicting adverse events of the oncology therapies, predicting objective response of the oncology therapies, predicting symptoms from the oncology therapies, and use of such predictions by technological implementations to achieve improved system and medical outcomes. An example technique for generating a predicted treatment outcome includes: receiving patient data for a human subject, which provides patient-reported outcomes collected from the human subject relating to a particular oncology treatment; processing the patient data with a trained artificial intelligence (AI) prediction model, which receives the patient data as input and produces a prediction of a treatment outcome as output; and outputting data to modify a treatment workflow of an oncology treatment for the human subject, based on the prediction of the treatment outcome.

The invention relates to a marker body (10) for marking breast tissue for radiotherapy. The marker body (10) has an at least partly tube-like body (12) which is made from a soft elastic material and carries multiple radio-opaque marker elements (18). The at least partly tube-like body (12) is designed so that it offers hardly any resistance to an external, deforming force, but returns to its original shape in the absence of external forces. The at least partly tube-like body (12) has two free longitudinal ends (14, 16) which can be detachably interconnected or are interconnected, resulting in a tubular ring.

Systems and methods for predicting outcome of radiation therapy is described herein. An example method includes receiving respective values for tumor volume of a target patients tumor at first and second time points, and calculating a change in tumor volume between the first and second time points. The method also includes estimating a patient-specific carrying capacity based on a logistic growth model and the change in tumor volume. Additionally, the method includes predicting a volume of the target patient's tumor at a future time point during radiation treatment based, at least in part, on a historical carrying capacity reduction fraction distribution and the patient-specific carrying capacity. The method further includes predicting a patient-specific outcome of radiation therapy for the target patient based, at least in part, on the predicted volume of the target patients tumor at the future time point.

A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.

Disclosed is a bore based medical system comprising a camera carrier configured to be mounted in the bore based medical system and configured to monitor and/or track patient motion within said bore based medical system during radiotherapy, the bore based medical system comprising a rotatable ring-gantry configured to emit a radiotherapy beam focused at an iso-center of the bore based medical system, wherein the ring-gantry is configured to rotate at least partly around a through-going bore having a front side and a back side, configured to receive from said front side, a movable couch configured to be moved into and out from the through-going bore, wherein further the through-going bore comprises an inner side facing an inside of the bore, and wherein the camera carrier is configured to be mounted inside the bore in connection with the inner side of the through-going bore.

Information associated with a radiation treatment plan includes, for example, values of dose per voxel in a target volume, values of dose rate per voxel in the target volume, and values of parameters used when generating the values of dose per voxel and the values of dose rate per voxel. Renderings that include, for example, a rendering of an image of or including the target volume, and a rendering of selected values of the radiation treatment plan, are displayed. When a selection of a region of one of the renderings is received, a displayed characteristic of another one of the renderings is changed based on the selection.

A radiotherapy device control apparatus instructs a radiotherapy device to execute instruction information based on a treatment regimen determined in advance, controls the operations of an irradiation-related instrument provided in the radiotherapy device on the basis of irradiation conditions included in the instruction information, determines whether irradiation is permitted on the basis of results detected by an irradiation target detection unit that detects movement of a target to be irradiated, controls execution and interruption of therapeutic irradiation on the basis of the determined result, stores the history of interruption of irradiation according to the determination by the irradiation permission determination unit, and causes the instrument to run the operations based on the instruction information to completion, regardless of whether irradiation has been interrupted during execution of the instruction information.

A treatment planning apparatus includes an overall data management unit for storing a target irradiation dose distribution to be formed in an irradiation object, a broad irradiation parameter calculation unit and a scanning irradiation parameter calculation unit for cooperatively calculating and determining operational parameters for devices, such as an accelerator and an irradiation nozzle, to operate during a broad irradiation and an scanning irradiation, respectively, so that the sum of irradiation doses imparted by both broad irradiation and scanning irradiation forms the target irradiation dose distribution.

Provided herein are devices and methods generating a panoramic rendering of a subject's teeth. Methods and processes are provided to image the subject's teeth with a dental scan. Methods and processes are also provided to automatically 3D render the subject's teeth with the scan images. Methods and apparatuses are also provided to generate simulated panoramic views of the subject's dentition from various perspectives.

Methods, systems, and compositions for maintaining functioning drainage blebs to reduce intraocular pressure (IOP) of an eye being treated for glaucoma. The methods, systems, and compositions feature the combination of a minimally invasive glaucoma surgery (MIGS) implant or procedure and the application of beta radiation to the bleb. The beta radiation can function to inhibit or reduce the inflammation and/or fibrogenesis that typically occurs after insertion of a MIGS implant and leads to bleb failure. By reducing inflammation and/or fibrogenesis, the MIGS implant and the blebs can remain functioning appropriately.