A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.

Information associated with a radiation treatment plan includes, for example, values of dose per voxel in a target volume, values of dose rate per voxel in the target volume, and values of parameters used when generating the values of dose per voxel and the values of dose rate per voxel. Renderings that include, for example, a rendering of an image of or including the target volume, and a rendering of selected values of the radiation treatment plan, are displayed. When a selection of a region of one of the renderings is received, a displayed characteristic of another one of the renderings is changed based on the selection.

Described herein are systems and methods for positioning a radiation source with respect to one or more regions of interest in a coordinate system. Such systems and methods may be used in emission guided radiation therapy (EGRT) for the localized delivery of radiation to one or more patient tumor regions. These systems comprise a gantry movable about a patient area, where a plurality of positron emission detectors, a radiation source are arranged movably on the gantry, and a controller. The controller is configured to identify a coincident positron annihilation emission path and to position the radiation source to apply a radiation beam along the identified emission path. The systems and methods described herein can be used alone or in conjunction with surgery, chemotherapy, and/or brachytherapy for the treatment of tumors.

A radiotherapy device control apparatus instructs a radiotherapy device to execute instruction information based on a treatment regimen determined in advance, controls the operations of an irradiation-related instrument provided in the radiotherapy device on the basis of irradiation conditions included in the instruction information, determines whether irradiation is permitted on the basis of results detected by an irradiation target detection unit that detects movement of a target to be irradiated, controls execution and interruption of therapeutic irradiation on the basis of the determined result, stores the history of interruption of irradiation according to the determination by the irradiation permission determination unit, and causes the instrument to run the operations based on the instruction information to completion, regardless of whether irradiation has been interrupted during execution of the instruction information.

Methods and devices for controlling movement of a carriage of a multi-leaf collimator are provided. In one aspect, a method includes obtaining a desired position of each of a set of leaves on the carriage in each of a plurality of segments from a field, determining an allowable moving range set of the carriage according to the desired position, the allowable moving range set including a respective allowable moving range of the carriage in each of the segments, determining a respective position of the carriage in each of the segments according to the allowable moving range set, and controlling the movement of the carriage according to the determined positions of the carriage in the segments.

The invention relates to a system for determining a radiation therapy plan for a radiation therapy system (100), comprising a multi-leaf collimator. The radiation therapy plan determination system (110) comprises a therapy system characteristics providing unit (111), wherein the characteristics comprise possible leaf positions and possible radiation fluence values, a planning objectives providing unit (112), wherein the planning objectives are indicative of a desired therapeutic radiation dose distribution, an optimization function providing unit (113), wherein the optimization function is indicative of a deviation of a radiation dose distribution from the planning objectives and of an uncertainty of the radiation dose distribution at edges of the possible apertures, and a therapy plan optimization unit (114) adapted to determine a sequence of possible apertures and possible radiation fluence values for which the optimization function is optimized. Thus, an optimal therapy plan can be provided for each individual patient.

An intraoral positioning device (IPD) is disclosed for positioning in a patient's mouth for radiation therapy planning and treatment, the device comprising an engagement member configured to engage structure within a patient's mouth during radiation planning or treatment, wherein the engagement member includes an upper wall, a lower wall and first and second side walls extending from and between the upper and lower walls, whereby the upper, lower and first and second side walls form top, bottom, front and rear walls of a bite block, and a handle extending from the engagement member to enable a user to grasp the IPD for introducing and removing it from the patient's mouth.

A method for adjusting a medical device is provided. The method includes obtaining an initial trajectory of a component of the medical device. The initial trajectory of the component includes a plurality of initial positions. For each of the plurality of initial positions, the method further includes determining whether a collision is likely to occur between a subject and the component according to the initial trajectory of the component. In response to the determination that the collision is likely to occur, the method further includes updating the initial trajectory of the component to determine an updated trajectory of the component.

Described are devices, systems, and methods for modulating the spectral energy distribution produced by an x-ray source via control of the energy of the x-ray-generating electron beam, e.g., for energy-modulated radiation therapy or other purposes. In some embodiments, such energy modulation is achieved by an add-on device to a linear accelerator. Also disclosed are computational methods and computer program products for planning energy-modulated therapy.

Described are devices, systems, and methods for modulating the spectral energy distribution produced by an x-ray source via control of the energy of the x-ray-generating electron beam, e.g., for energy-modulated radiation therapy or other purposes. In some embodiments, such energy modulation is achieved by an add-on device to a linear accelerator. Also disclosed are computational methods and computer program products for planning energy-modulated therapy.