The invention is directed to biomarkers for predicting a patient's response, both therapeutic and toxic, to immunotherapy.

A beam shaping assembly for neutron capture therapy includes a beam inlet, a target having nuclear reaction with an incident proton beam from the beam inlet to produce neutrons forming a neutron beam, a moderator adjoining to the target, a reflector surrounding the moderator, a thermal neutron absorber adjoining to the moderator, a radiation shield arranged inside the beam shaping assembly and a beam outlet. The material of the moderator is subjected to a powder sintering process using a powder sintering device so as to change powders or a power compact into blocks. The reflector leads the neutrons deviated from the main axis back. The thermal neutron absorber is used for absorbing thermal neutrons so as to avoid overdosing in superficial normal tissue during therapy. The radiation shield is used for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation.

The invention comprises a method and apparatus for tracking and/or imaging impact of a particle beam treating a tumor using one or more imaging systems positionable about the tumor, such as a positron emission tracking and/or imaging system, where resulting tracking/imaging data: dynamically determines a treatment beam position, tracks a history of treatment beam positions, guides the treatment beam, and/or images a tumor before, during, and/or after treatment with the charged particle beam.

A treatment planning apparatus includes an overall data management unit for storing a target irradiation dose distribution to be formed in an irradiation object, a broad irradiation parameter calculation unit and a scanning irradiation parameter calculation unit for cooperatively calculating and determining operational parameters for devices, such as an accelerator and an irradiation nozzle, to operate during a broad irradiation and an scanning irradiation, respectively, so that the sum of irradiation doses imparted by both broad irradiation and scanning irradiation forms the target irradiation dose distribution.

A reusable joint for a medical linac, a reusable CF choke flange for a medical linac, a linac and a method for forming a reusable joint for a medical linac are disclosed. The reusable joint comprises a CF choke flange, a CF cover flange and a gasket. The CF choke flange comprises a first waveguide aperture, a choke groove and a first CF groove comprising a first knife-edge, wherein the choke groove is disposed radially inwards from the first CF groove on the CF choke flange. The CF cover flange comprises a second waveguide aperture aligned with the first waveguide aperture and a second CF groove comprising a second knife-edge and aligned with the first CF groove. The gasket is disposed between and in contact with the first CF groove and the second CF groove.

A particle-accelerator diagnostic technology capable of evaluating extraction efficiency of charged particles in a short cycle is provided.

A diagnostic device for a particle accelerator includes: a first receiver configured to receive a first detection signal from a first detector that detects a first current value generated by movement of charged particles in a circular accelerator, the first detection signal being outputted as a signal corresponding to the first current value; a second receiver configured to receive a second detection signal from a second detector that detects a second current value generated by movement of charged particles extracted from the circular accelerator into a beam transport system, the second detection signal being outputted as a signal corresponding to the second current value; and a calculator configured to calculate an extraction efficiency of charged particles based on the first and second detection signals.

Methods and systems are disclosed for radiating a moving object. The method may comprise acquiring a plurality of indicators of the phase of a physiological cycle of a patient and a plurality of images of the patient that include a target. Each image may be taken at a different phase of the physiological cycle and may be registered to the phase at which the image was taken. The method may also include identifying the target in each of the plurality of images, calculating a dose of radiation required to treat the target, calculating the number, orientation, and dwell time of one or more radiation beams required to deliver the calculated required dose of radiation to the target, and calculating a position of each of the one or more radiation beams required to achieve the calculated orientation. Each position may be a function of the phase of the physiological cycle to which each of the plurality of images is registered.

A radiotherapy system (220, 320) comprises a first rotary support apparatus (204, 304) configured to support a radiation beam source (200, 300) and to cause a radiation beam source (200, 300) to rotate about a rotation axis (218, 318, 518), a second rotary support apparatus (214, 314, 414, 514) and a radiation shield (202, 302, 402, 502) mounted to the second rotary support apparatus (214, 314, 414, 514). The second rotary support apparatus (214, 314, 414, 514) is configured to cause the radiation shield (202, 302, 402, 502) to rotate about the rotation axis (218, 318, 518).

The present disclosure provides methods of treating cancer in a patient comprising administering a combination of a low dose radiotherapy and an immune checkpoint inhibitor therapy. The patient may be further administered a cell therapy, such as chimeric antigen receptor T-cell therapy or chimeric antigen receptor NK-cell therapy. The low dose radiation modulates the tumor microenvironment of solid tumors to allow better efficacy, activation, and infiltration of the anti-tumor effector immune cells.

An x-ray treatment system includes an electron beam generator configured to generate an electron beam and an x-ray treatment head comprising an array of pixel source cells including side walls defining an x-ray transmissive interior. The side walls include an x-ray absorptive material. A target element is positioned to, when impacted by the electron beam, generate x-ray photon radiation within the x-ray transmissive pixel source cell interior. An electron beam control system includes a controller configured to control responsive to a treatment plan at least one of the direction and intensity of the electron beam to a particular one of the pixel source cells, and then responsive to the treatment plan to control at least one of the direction and intensity of the electron beam to at least one additional pixel source cell. A method of treating a patient with x-ray photon radiation is also disclosed.