A collection system for recovering a separated radioactive fraction, comprising: a collection inlet configured to receive a fraction from a separation system, a radio detector configured to determine the radioactivity of the fraction and generate a radiodetection signal based on the determined radioactivity, a collection valve system in fluid communication with the collection inlet, wherein the collection valve system comprises at least one or more of the collection vessel outlets and a waste outlet, a control unit configured to control the collection valve system to guide the fraction to one of the collection vessel outlets or a waste outlet.

A chromatographic purification method for the isolation of a product from a feed mixture using two columns, wherein in one step b) the first upstream column is loaded with feed, followed by at least one interconnected step c), wherein in the interconnected step c) the first column is fed with eluent with a gradient, wherein the stream exiting the first column is adjusted inline with inline adjustment eluent before entering the second column during the period of gradient elution, and wherein the inline adjustment eluent is as the eluent fed at the first column inlet but controlled to have a higher or lower modifier concentration than the eluent exiting at the first column, and wherein the modifier difference of the inline adjustment eluent is chosen such that the adherence of the product to the stationary phase of the second column is higher than without that difference.

Continuous monitoring of density in extraction and recovery using pressure density sensors is described herein. Metal recovery methods and processes using pressure density sensors are also described herein. A method comprises providing an aqueous material containing target ions to a direct extraction unit; extracting target ions from the aqueous material containing target ions using a selective withdrawal medium to yield an extract and a depleted material; using a pressure density sensor to determine a first density of the aqueous material containing target ions; using a pressure density sensor to determine a second density of the depleted material; comparing the first density with the second density; and operating the direct extraction unit based on the comparison.

A method of monitoring a chemical process in a column apparatus using a measurement system is disclosed, the column apparatus being configured to contain a solid stationary phase, receive a liquid mobile phase, and enable flow of the mobile phase through the stationary phase in a flow direction. The measurement system comprises a set of electrodes arranged at a sensing location of the column apparatus. The method comprises: providing the solid stationary phase within the column apparatus; causing the liquid mobile phase to flow through the stationary phase in a flow direction; applying an electrical stimulation to the set of electrodes; receiving an electrical signal from the set of electrodes; and determining one or more characteristics of a chemical interaction between the solid stationary phase and the liquid mobile phase by processing the electrical signal received from the set of electrodes.

Continuous monitoring of density in lithium extraction and recovery using inertial density sensors is described herein. Lithium recovery methods and processes using inertial density sensors are also described herein. A method comprises detecting a first density of an aqueous material using an inertial density sensor; performing an operation on the aqueous material to change a lithium concentration of the aqueous material; after performing the operation, detecting a second density of the aqueous material using an inertial density sensor; comparing the first density with the second density; and determining a change in concentration of lithium in the aqueous material based on the comparison.

A process and circuit for direct lithium extraction (DLE) from natural or synthetic lithium-bearing solutions is disclosed, utilizing an alumina-based lithium selective adsorbent. The process circuit employs a monovalent salt wash solution, such as sodium chloride (NaCl) or potassium chloride (KCl), to displace impurities (e.g., boron, calcium, magnesium) from the adsorbent, followed by elution with water or a dilute salt solution to recover lithium. The process circuit improves the lithium-to-impurity ratio in the eluate, reduces operational and capital expenditures, and minimizes waste by recycling displaced impurities into the brine feed stream.

A sample analysis method includes obtaining chromatography data of a plurality of separated materials that are separated from a sample, obtaining mass spectra corresponding to first peaks of the chromatography data, determining, based on the obtained mass spectra, at least one peak corresponding to a target material from the first peaks of the chromatography data, and selecting a protocol for separating the sample based on a result of analyzing the at least one peak corresponding to the target material.

A method for modifying the flow capabilities of an existing tangential flow filtration (TFF) system is contemplated in which the processing capabilities of the existing static TFF system may be increased without requiring the addition of additional systems running in parallel. This may be achieved via adjusting or replacing certain of the components of the TFF skid to accommodate a tubing set having a larger (or smaller) internal diameter than the existing tubing set or the tubing set for which the TFF system was originally manufactured. In this fashion, it may be seen that an existing skid may have its flow capabilities dramatically increased. It is further contemplated that a retrofit kit for an existing TFF system for use according to the described method may be provided.

A sample separation device for separating a fluidic sample includes a fluid drive arrangement for driving a mobile phase along a flow path to a sample separation unit, a sampler for sampling the fluidic sample, and a control device configured to control the metering device to thereby actively damp a fluctuation in the fluid drive arrangement operation. The sampler may include a metering device.

For the preparative separation of sample components accompanying a sample injection for each of plural sample injections, a preparative liquid chromatograph is controlled as follows: In the preparative separation of sample components accompanying the first sample injection, the separative collection of a sample component corresponding to a peak is performed by a separative collector for each peak emerging on a chromatogram, and the beginning time of each peak on the chromatogram is stored. In the preparative separation of sample components accompanying the second or subsequent sample injection, every peak emerging on the chromatogram is designated as a target peak, whether or not the target peak originates from the same component as one of the peaks is determined based on the beginning time of the target peak and those of the peaks, and the separative collector is operated to perform a predetermined separative collection operation based on the determination result.