The present invention relates to a method of purifying a target component from a full plasma sample. The present invention further relates to a method of removing one or more target components from a full plasma sample.

A separation system and methods for separating and purifying a target component include a separation system for separating and purifying a target component, a method for separating and purifying a target component, and the use of a single-pass crossflow diafiltration unit for integrally connecting a first and a second chromatography device.

The invention relates to membranes for separation, removal, and/or concentration purposes. The object of the invention is the simple and reliable adsorption of the molecules and to simplify the desorption of target molecules that are adsorbed and chromatographically bonded on membranes, preferably without the addition of substances with a high ion content, such as acids, alkalis or salts. The object of the invention is also to develop a value that can be easily measured, which allows for an indication of the current and/or remaining binding capacity of the membrane during the adsorption process and/or the control thereof. The adsorption takes place on a charged membrane and desorption is achieved using physical, electromagnetic and/or the generation of electrical fields. This is carried out with a thin metal layer being applied to one or both sides of a positively or negatively charged membrane and a voltage is applied for desorption.

A method for modifying the flow capabilities of an existing tangential flow filtration (TFF) system is contemplated in which the processing capabilities of the existing static TFF system may be increased without requiring the addition of additional systems running in parallel. This may be achieved via adjusting or replacing certain of the components of the TFF skid to accommodate a tubing set having a larger (or smaller) internal diameter than the existing tubing set or the tubing set for which the TFF system was originally manufactured. In this fashion, it may be seen that an existing skid may have its flow capabilities dramatically increased. It is further contemplated that a retrofit kit for an existing TFF system for use according to the described method may be provided.