A method of acoustophoresis using selection particles that alter acoustic response is provided. The method can include selecting a set of selection particles based on surface markers of a plurality of target particles to be separated using acoustophoresis. The method can include incubating the set of selection particles with the plurality of target particles in a solution such that the set of selection particles bind with the surface markers on the plurality of target particles to create a plurality of bound particles. The method can include providing the plurality of bound particles to an acoustophoresis device tuned to separate the particles based on a net acoustic contrast between each of the plurality of bound particles. The method can include receiving a plurality of output streams from the acoustophoresis device that each include a respective bound particle of the plurality of bound particles.

A system for separating solids from a fluid mixture includes a vessel including a first chamber to receive a solid-laden fluid mixture, and a second chamber to receive liquids separated from the solid-laden fluid mixture. In certain aspects, at least one eductor is disposed in the first chamber to flow the solid-laden fluid mixture out of the first chamber. In certain aspects, an auger is disposed in the first chamber to move at least solids of the solid-laden fluid mixture out of the first chamber.

A particle recovery device for recovering particles contained in a liquid sample, the particle recovery device comprising: a flow cell having a flow path through which the liquid sample flows; a density acquisition unit that acquires a density of the liquid sample; standing wave forming means that applies an ultrasonic wave into the flow path to generate a standing wave; a control unit that determines a frequency of the ultrasonic wave that generates the standing wave in the flow path based on the density acquired by the density acquisition unit and causes the standing wave forming means to apply the ultrasonic wave of the determined frequency; and recovery means that recovers particles focused in the flow path by the standing wave.

A sonicator assembly, including: a microplate defining a plurality of wells; a manifold for containing a transducer fluid that is thermally coupled to the plurality of wells of the microplate; an ultrasonic generator operable for applying an ultrasonic excitation to the wells of the microplate; one or more of a heating module thermally coupled to and operable for selectively heating the transducer fluid and a cooling module thermally coupled to and operable for selectively cooling the transducer fluid; and a controller operable for controlling operation of the ultrasonic generator and the one or more of the heating module and the cooling module. The controller is further operable for monitoring a temperature and a pressure within the manifold. A temperature of the plurality of wells is controllable over a temperature range from 4° C. to 95° C. Optionally, the plurality of wells include a plurality of heat-resistant round-bottom hydrophilic wells.

Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating target particles from elements of whole blood. The whole blood and capture particles are flowed through a microfluidic separation channel formed in a thermoplastic. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements of the blood and target particles to specific aggregation axes.

Provided is a method for recycling a polishing agent slurry comprising: a first process including a slurry collecting process of collecting the used polishing agent slurry discharged from a polishing device; a desalting treatment process of reducing an ion concentration of the collected polishing agent slurry; and a dispersion treatment process of dispersing the polishing agent component and the constituent component of the object to be polished by adding a pH adjusting agent and a dispersing agent to the desalted polishing agent slurry; and after the first process, a second process of preparing a recycled polishing agent slurry from the polishing agent component by separating the polishing agent component and the constituent component of the object to be polished.

Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study.

Disclosed herein are systems and methods of purification of liquid from colloidal particles. More specifically, disclosed are systems and methods for treating water by effecting aggregation of colloidal particles and thus improving their sedimentation, by enhancing grouping of the particles using accelerating, decelerating, and reversing velocity gradients within the liquid. The disclosed methods and systems for water treatment allow for continuous treatment of a contaminated water stream in a single flocculation and sedimentation vessel (i.e. a hybrid process).

Techniques for separating cuttings from liquid include circulating a drilling fluid that comprises a liquid and formation cuttings to a scree of a screen assembly that includes screen sections; vibrating the screen assembly during circulation of the drilling fluid; while vibrating the screen assembly, separating the liquid from the plurality of formation cuttings; while vibrating the screen assembly, separating a first portion of the formation cuttings of a first size from the drilling fluid with a first screen section; rotating the screen assembly; subsequent to rotating the screen assembly and while vibrating the screen assembly, separating a second portion of the formation cuttings of a second size different than the first size from the drilling fluid with a second screen section; directing the separated liquid through the screen assembly to a liquid outlet; and directing at least one of the first or second portions of the formation cuttings to a cuttings outlet formed in the screen.

A system for enhancing the separation of particles or fluids from water is disclosed. A tank or bioreactor is provided with an open submersible acoustophoretic separator. The separator captures and holds fluid droplets or particles such as cells, permitting them to coalesce or agglomerate until they are large enough and have sufficient buoyant or weight force to float/sink to the top/bottom of the tank or bioreactor. In a tank or bioreactor, the separator captures and holds particles until they are large enough that their weight causes them to settle out of the host fluid. The acoustophoretic device thus speeds up separation of the particles or droplets from the host fluid.