B01D2311/26

ENHANCED PURIFICATION OF ADENO-ASSOCIATED VIRUS TO MORE EFFECTIVELY REMOVE CONTAMINATING DNA

A method for reducing a contaminating DNA content of a preparation containing AAV capsids and contaminating DNA, comprising the steps of a) Performing an extraction of DNA with a solid phase bearing positive charges at its surface said solid phase is contacted with the preparation at a pH of 7.0±1.0, and a salt concentration of 10 mM to 200 mM yielding a first fraction, (b) Diafiltering the first fraction by a first tangential flow filtration to obtain a second fraction, (c) Treating the second fraction with DNase, (d) Diafiltering the DNase treated second fraction obtained by step c) by a second tangential flow, (e) filtration to a buffer with pH of 7.0±1.0, and a salt concentration of 10 mM to 20 mM to yield a third fraction, and optionally (f) Concentrating the third fraction by tangential flow filtration before supplemental chromatography.

BIMODAL REVERSE OSMOSIS AND PRESSURE RETARDED OSMOSIS FRAMEWORK

A method of operating a dual reverse osmosis/pressure retarded osmosis plant, including when electricity costs less than a first predetermined price, moderate salinity water is pumped into the first portion of a pressure vessel having first and second portions separated by a water permeable/salt impermeable osmotic membrane to yield desalinated permeate in the second portion and brine in the first portion. Further, when electricity costs greater than the first predetermined price, low salinity water is pumped into the second portion and brine is pumped into the first portion to yield pressurized moderate salinity water in the second portion which is run through an energy recovery device to generate electricity. The salinity of the low salinity water is lower than the salinity of the moderate salinity water, and the salinity of the moderate salinity water is lower than the salinity of the brine.

WASTEWATER TREATMENT APPARATUS
20220371934 · 2022-11-24 ·

An apparatus for the treatment of wastewater having: a primary treatment module with at least one solids separation filter; a secondary treatment module with at least one microflotation unit and at least one oxidation treatment unit placed downstream of the at least one microflotation unit, the at least one oxidation treatment unit has an advanced oxidation process module for performing chemical processes, the advanced oxidation process module performing an ozone and hypochlorite treatment; a tertiary treatment module including at least one membrane filtration unit; the apparatus provided with sequentially flowing wastewater from the primary treatment module, through the secondary treatment module, and to the tertiary treatment module. A method for wastewater treatment in an apparatus having as sequentially treating wastewater through the primary treatment module, the secondary treatment module, and the tertiary treatment module.

APPARATUS AND METHOD FOR CONTROLLING REVERSE OSMOSIS MEMBRANE SEAWATER DESALINATION PLANT

Provided is an apparatus for controlling a seawater desalination plant. The apparatus includes: a dissolved air flotation device configured to provide treated water obtained by treating seawater according to a dissolved air flotation (DAF); an ultrafiltration device including a plurality of ultrafiltration units each having an ultrafiltration membrane, and configured to perform an ultrafiltration (UF) process of filtering impurities remaining in the treated water using the ultrafiltration membranes of the plurality of ultrafiltration units; a reverse osmosis device; an information collection unit; and a state treatment unit.

APPARATUS AND METHOD FOR CONTROLLING REVERSE OSMOSIS MEMBRANE SEAWATER DESALINATION PLANT

Provided is an apparatus for controlling a seawater desalination plant. The apparatus includes: a dissolved air flotation device configured to provide treated water obtained by treating seawater according to a dissolved air flotation (DAF); an ultrafiltration device including a plurality of ultrafiltration units each having an ultrafiltration membrane, and configured to perform an ultrafiltration (UF) process of filtering impurities remaining in the treated water using the ultrafiltration membranes of the plurality of ultrafiltration units; a reverse osmosis device; an information collection unit; and a state treatment unit.

METHODS FOR RECOVERING ORGANIC ACIDS OR SALTS OR LACTONES THEREOF FROM AQUEOUS SOLUTIONS USING WATER SOLVENT CRYSTALLIZATION AND COMPOSITIONS THEREOF

Compositions and methods are provided for producing crystalline forms of organic acids or salts or lactones thereof from an aqueous solution. More specifically, methods are provided for producing a crystalline form of a salt of mevalonic acid (also referred to as X-MVA) from an aqueous solution, comprising subjecting the aqueous solution comprising said X-MVA to a purification step to produce a purified solution and crystallizing said X-MVA from said purified solution by water solvent crystallization. Methods are also provided for producing mevalonolactone from an aqueous solution comprising X-MVA, comprising subjecting the aqueous solution comprising said X-MVA to cation exchange thereby converting said aqueous solution comprising X-MVA to an aqueous solution comprising mevalonolactone (MVL). Methods are also provided for producing mevalonolactone monohydrate crystals.

PLANT OIL EXTRACTION DEVICE
20220315859 · 2022-10-06 ·

A plant oil extraction device includes one or modules for extraction of a product, e.g., oil, from a plant biomass. Various embodiments of the plant oil extraction device are described that include one or more features for producing a clean organic stream, free from waxes and terpenes, from biomass feedstocks such as industrial hemp. Related systems, methods, and articles of manufacture are also described.

Removal of contaminating viruses from AAV preparations

The present invention relates to a separation of viruses of an essentially spherical shape from viruses with a rod-like shape that are comprised in a sample, wherein the sample comprising the viruses is subjected to filtration.

Method and Apparatus for Advanced Vacuum Membrane Distillation

Embodiments provide methods and strictures for purification or volume reduction of a brine by an advanced vacuum distillation process (AVMD) to achieve higher flux by passage of vapors through an AVMD distillation unit. In one example, brine is circulated in a tank. The tank may include one or more membrane pouches that are submerged in the circulating brine or placed above the water level of the hot circulating brine. In other embodiments the membrane pouches are outside of the tank that includes the hot circulating brine but still in communication with it. The circulating brine is heated, allowing creation of water vapor. Using a vacuum, the water vapor is drawn through the membrane, where it may be condensed and subjected to further beneficial use. This process can concentrate to levels to generate crystals or solids, which can be separated and utilized.

MULTI-STAGE SUBMERGED MEMBRANE DISTILLATION WATER TREATMENT APPARATUS AND A RESOURCE RECOVERY METHOD USING SAME

A multi-stage submerged membrane distillation water treatment apparatus including: a plurality of raw water tanks arranged in multiple stages ranging from a first stage to an n-th stage and storing raw water, the raw water flowing sequentially from the first stage to the n-th stage; membrane distillation (MD) modules submerged in the respective raw water tanks and discharging a portion of the raw water as vapor; heat exchangers submerged in the respective raw water tanks and maintaining the raw water at a predetermined temperature by performing heat exchange between the raw water and vapor supplied from the respective previous-stage MD modules; a vapor generator generating and supplying high-temperature vapor to the first-stage heat exchanger; a condenser condensing vapor supplied by the n-th-stage MD module; and a raw water feeder feeding low-temperature raw water to the first-stage raw water tank via the condenser.