A method is disclosed for monitoring deposit formation in an aqueous process. The method includes providing a feed flow of aqueous liquid onto a receiving surface of a monitoring cell. At least part of the receiving surface is illuminated with a light source. Visual data is collected at a multitude of positions across the receiving surface, and the collected visual data is analysed. A quantitative scaling and/or fouling indication is computed for the receiving surface. The monitoring cell has an inlet for the aqueous feed flow and an outlet for a reject flow from the monitoring cell. The receiving surface includes a selective barrier membrane. The feed flow is directed to the receiving surface at an elevated pressure to produce a permeate part that passes through the selective barrier membrane, and a concentrate part that forms the reject flow.

The present disclosure provides a cell separation apparatus for a bioreactor. The cell separation apparatus may be disposed outside the bioreactor and in fluid connection with the bioreactor, the cell separation apparatus may be in a shape of a box body, the cell separation apparatus may include a liquid buffer device including a first liquid cavity disposed in the box body; a filter device including a filter channel and a filter membrane disposed in the box body, the filter membrane may be disposed above the filter channel; and a first liquid channel may be configured in the box body to facilitate a fluid communication between the first liquid cavity and the filter channel. A power system for filtering and microfluidic channels are integrated in the cell separation apparatus that is of a box shape, thereby reducing the volume and production cost thereof.

A method of filtering a large volume of a medium using a pre-sterilizable, at least partially automated single-use filtration device which includes an unfiltrate inlet, a filtrate outlet, a main line running between the unfiltrate inlet and the filtrate outlet, filter elements arranged in the main line, a venting line and sensors for detecting specific process parameters and regulating means for adjusting specific process parameters, wherein the sensors and regulating means are connected to an external monitoring and control system which is adapted for evaluating and processing sensor data and for piloting the regulating means based on one or more control algorithms, comprises the following process steps: a) filling the single-use filtration device with medium with low flow; b) venting the single-use filtration device through the venting line; c) closing the venting line; d) rinsing the single-use filtration device, in particular the filter elements; e) filtering the medium by means of the filter elements; f) re-rinsing with high flow; and g) closing the main line; wherein the process steps f) and g) are optional.

Ultrapure water supply apparatuses, substrate processing systems, and substrate processing methods are provided. An ultrapure water supply apparatus includes: a first supply device that produces first ultrapure water; a second supply device that produces second ultrapure water; a first reserved supply device that provides the second supply device with a portion of fluid in the first supply device; and a second reserved supply device that provides the first supply device with a portion of fluid in the second supply device. The first supply device includes a first front-side filtering part, a first rear-side filtering part, and a first connection part. The second supply device includes a second front-side filtering part, a second rear-side filtering part, and a second connection part. Each of the first and second reserved supply devices connects the first connection part and the second connection part to each other.

A system for TFF filtration of a feedstock includes a feed vessel containing a solution comprising a target biomolecule, a filter membrane for filtering the solution, a feed pump for moving the solution from the feed vessel to the filter membrane, a buffer vessel coupled to the feed vessel by a buffer supply line, and a diafiltration pump disposed in the buffer supply line for delivering a buffer solution to the feed vessel. A variable path-length instrument is coupled to the feed line for determining, in real time, a concentration of the target biomolecule in the solution. A controller is coupled to the variable path-length instrument, the feed pump, and the diafiltration pump to control operation of the system based on the received information.

A fluorometric monitoring technique can be used to rapidly evaluate the efficiency of an osmosis membrane. In some examples, the technique includes injecting a bolus of fluorescent tracer into a feed stream. The tracer may be introduced for a period of time less than what is required for the tracer to reach an equilibrium concentration in the permeate stream. The feed stream and the permeate stream may be fluorometrically analyzed to determine a flow rate-independent cumulative-time concentration of the fluorescent tracer in the both streams. The efficiency of the osmosis membrane can then be determined based on these flow rate-independent cumulative-time concentrations.

A membrane defect inspection method that can detect damage in a filtrate membrane and can detect presence or absence of damage or a seal defect in a membrane module; and the method is for a membrane module set including multiple membrane modules connected under gas detection piping communicating with primary spaces of the multiple membrane modules where raw water is supplied or secondary spaces in multiple membrane modules where treated water is extracted after the raw water is filtrated by membranes. The method includes a gas injection process where gas is injected into spaces opposite the primary or secondary spaces communicating with gas detection piping in the multiple membrane modules while the gas detection piping is filled with water, and a vibration detection process where a vibration sensor is brought into contact with a protrusion protruding outward from the gas detection piping to detect vibration of the gas detection piping.

A method and apparatus for evaluating a condition of a water purification system (40, 110) comprising a water purification apparatus (110) arranged to output purified water through an outlet (128) and through at least one sterilizing grade filter (70a, 70b) of a line set (40) fluidly connected to the outlet (128), the method comprises: monitoring a flow rate (S1) correlated with the flow rate of the purified water flowing through the at least one sterilizing grade filter (70a, 70b); monitoring a pressure (S2) correlated with the pressure of the purified water flowing to the at least one sterilizing grade filter (70a, 70b); and evaluating (S3) a condition of the water purification system based on a relationship between the monitored flow rate and the monitored pressure.

The proposed prefabricated filtration module is provided for a modular filtration system, in particular a cross-flow filtration system, for low-volume screening applications. The prefabricated filtration module includes fluid ports and a plurality of components adjusted to low-volume screening applications, which are firmly integrated into the filtration module. The entire filtration module is designed as a single-use filtration module.

Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.