Methods for controlling a spinning membrane separator so as to limit fouling of the membrane by changing the rotation rate of the spinning membrane in response to the fouling rate, while maintaining a constant outlet cellular concentration. Increasing the spinner rotation rate will increase the strength of the Taylor vortices generated within the separator by the spinning of the membrane, which should reduce fouling of the membrane. The goal of the method is to rotate the spinning membrane at the slowest rate possible without unacceptable fouling. Two specific methods to control fouling are disclosed. In a first, unidirectional method, the spin rate of the membrane is only increased in response to undesirable fouling in order to prevent the fouling from continuing. In a second, bidirectional method, the spin rate of the membrane may be either increased or decreased in response to the measured fouling rate in order to maintain the fouling rate within a desired range.

Systems and methods for the washing and processsing of biological fluid/biological cells are disclosed. The systems and methods prevent inadvertent target cell loss by monitoring pressure and providing for the dilution of the cell feed.

The filtration system having a housing having an inlet, at least one outlet being axially spaced from the inlet and forming a helical purge path therebetween, and a filtrate outlet extending out along the axis, with a flow rate ratio being balanced by flow restriction between the filtrate outlet and the at least one purge outlet during regular operation; a filter element including a filtration membrane and a support membrane mounted concentrically around the axis, at least one of said filtration membrane and support membrane being rotatably mounted to the housing for rotation about the axis to impart a relative rotation speed between the filtration membrane and support membrane during operation; the system being operable to temporarily increase the flow rate ratio through the at least one outlet compared to said regular operation.

A method and system for collecting leukoreduced red blood cells employing a spinning membrane separator including a housing having an upper end region and a lower end region in an operating position with a red blood cell outlet in the upper end region of the housing and a whole blood inlet in the lower end region of the housing. The method and system provide for flowing additive solution into the whole blood inlet of the housing to prime the separator; flowing whole blood into the whole blood inlet of the housing; separating red blood cells from the whole blood; flowing separated red blood cells out of the red blood cell outlet of the housing; combining the separated red blood cells with additive solution: passing the separated red blood cells and additive solution combination through a leukoreduction filter; and collecting the filtered red blood cells and additive solution.

Pressure processing systems disclosed herein comprise rotating fluid flow paths. Transfer of angular momentum between the working fluid and the fluid flow path may be configured to increase pressure within the system and/or recover energy used to increase pressure within the system. Rotation of pressure processing systems may be configured to alter working fluid pressure within the pressure processing system. Filtration and/or chemical processes may be performed within a pressure processing portion of such systems. Working fluid may be introduced or recovered from the system at various radial positions.

Pressure processing systems disclosed herein comprise rotating fluid flow paths. Transfer of angular momentum between the working fluid and the fluid flow path may be configured to increase pressure within the system and/or recover energy used to increase pressure within the system. Rotation of pressure processing systems may be configured to alter working fluid pressure within the pressure processing system. Filtration and/or chemical processes may be performed within a pressure processing portion of such systems. Working fluid may be introduced or recovered from the system at various radial positions.

Systems and methods for performing hemodialysis to remove metabolic waste from the blood of a patient are disclosed. The systems and methods preferably comprise at least one blood processing apparatus that receives whole blood from a patient. Cellular blood components are removed from the whole blood by hemofiltration, to provide filtered plasma comprising metabolic waste that is substantially reduced of blood cells. The cellular blood components may be returned to the patient. The filtered plasma comprising waste may be removed from the blood processing apparatus through a waste path for further processing in a separate apparatus, or in the same apparatus in a second stage processing procedure to remove metabolic waste components and excess water from the plasma by hemodialysis. At least one of the hemofiltration and hemodialysis processing apparatus comprises a Taylor vortex-enhanced separation apparatus.

The treatment system provides a feature that may reduce cost of the electrochemical plating process by reusing the virgin makeup solution in the spent electrochemical plating bath. The treatment system provides a rotating filter shaft which receives the spent electrochemical plating bath and captures the additives and by-products created by the additives during the electrochemical plating process. To capture the additives and the by-products, the rotating filter shaft includes one or more types of membranes. Materials such as semi-permeable membrane are used to capture the used additives and by-products in the spent electrochemical plating bath. The treatment system may be equipped with an electrochemical sensor to monitor a level of additives in the filtered electrochemical plating bath.

During a first stage of a priming procedure, a priming fluid is conveyed into a spinning membrane separator via a filtrate outlet port so as to convey air out of the spinning membrane separator via an inlet port and a retentate outlet port of the spinning membrane separator. During an optional second stage of the priming procedure, the priming fluid is conveyed into the spinning membrane separator via the inlet port so as to convey air out of the spinning membrane separator via the retentate outlet port. A rotor positioned within a housing of the spinning membrane separator may be rotated with respect to the housing during the first and second stages to force air from within the rotor into an annulus defined between the rotor and the housing for more complete priming of the spinning membrane separator.

The treatment system provides a feature that may reduce cost of the electrochemical plating process by reusing the virgin makeup solution in the spent electrochemical plating bath. The treatment system provides a rotating filter shaft which receives the spent electrochemical plating bath and captures the additives and by-products created by the additives during the electrochemical plating process. To capture the additives and the by-products, the rotating filter shaft includes one or more types of membranes. Materials such as semi-permeable membrane are used to capture the used additives and by-products in the spent electrochemical plating bath. The treatment system may be equipped with an electrochemical sensor to monitor a level of additives in the filtered electrochemical plating bath.