A method for membrane filtration of water comprising alternating in-line additions of coagulant and adsorbent to the water upstream of the membrane, wherein each addition time is in a range from 10 seconds to one hour.

A submerged water purification system including a plurality of spiral wound hyperfiltration membrane modules each connected in a parallel flow arrangement to a common feed manifold and a common permeate manifold; wherein each module includes at least one feed spacer sheet and one membrane envelop wound about a permeate collection tube having a plurality of openings along its length that are in fluid communication with the membrane envelop, and further including an end cap secured to an end of the module with a manifold junction reversibly connected to the end cap of each module, wherein the manifold junction provides a sealed fluid communication between the feed spacer sheets and permeate collection tubes of each module to the feed manifold and permeate manifold, respectively.

A perfusion bioprocessing system (10) includes a bioreactor (12) and a recirculation flow path (14) provided with at least in one first feed flow control device (46) and at least one second feed control device (48). The perfusion bioprocessing system (10) further includes a first tangential flow filter (16) coupled to the bioreactor (12) via the recirculation flow path (14) and a second tangential flow filter (18) coupled to the bioreactor (12) via the recirculation flow path (14). The first tangential flow filter and the second tangential flow filter are coupled to a permeate flow path and a retentate flow path. Additionally, the perfusion bioprocessing system (10) includes a control unit (90) coupled to the at least one first feed flow control device (38) and the at least one second feed control device (40).

The present invention relates to systems and methods for filtration and/or dilution of fluids, in particular for the dialysis of blood. The systems comprise a filter device (10) having a fluid chamber (18) and comprising a first lid (20) having arranged thereon a first fluid port (22). The filter device (10) further comprises a second lid (30) having arranged thereon at least a second fluid port (32). The filter device (10) further comprises a plurality of hollow fibers (40) arranged within the housing (12), wherein each of the plurality of hollow fibers (40) comprises a semi-permeable membrane and defines a fluid channel extending longitudinally through an interior of the respective hollow fiber (40). Also, the filter device (10) comprises a fourth fluid port (50) and a fifth fluid port (52) both provided at the fluid chamber (18).

A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator. The hardware component comprises a pump for flowing the suspension of biological cells to the inlet of the separator and at least one flow control device associated with the first outlet and the second outlet of the separator for selectively opening and closing the outlets so as to permit one of the first type of cells and the second type of cells to flow out of the separator in accordance with a predetermined duty cycle equal to the ratio of a target flow rate of first type of cells through the first outlet to the predetermined inlet flow rate.

A means capable of simply and efficiently concentrating a cell suspension. A concentrator has a culture vessel having a first port and a second port, a server bag having a port, a case having a hollow fiber bundle in the internal space, a filtering device having an inlet port, a first outlet port, and a second outlet port, a collection vessel having a port, a liquid supply circuit connected to the first port, the inlet port, and the server bag's port so that flow passages are switchable, a liquid discharge circuit connected to the second port, the first outlet port, the second outlet port, and the collection vessel's port so that flow passages are switchable, a liquid supply mechanism having a switching mechanism, a supply pump, and a discharge pump, and a rotation mechanism rotating the filtering device.

A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator. The hardware component comprises a pump for flowing the suspension of biological cells to the inlet of the separator and at least one flow control device associated with the first outlet and the second outlet of the separator for selectively opening and closing the outlets so as to permit one of the first type of cells and the second type of cells to flow out of the separator in accordance with a predetermined duty cycle equal to the ratio of a target flow rate of first type of cells through the first outlet to the predetermined inlet flow rate.

Provided is a filtration device including: a flow path that meanders; a filtration membrane that separates a supply side and a permeation side of the flow path; a first distribution port that is provided at one end of the supply side of the flow path; a second distribution port that is provided at the other end of the supply side of the flow path; a first discharge port that is provided on the permeation side of the flow path; and a second discharge port that is provided at a position different from that of the first discharge port on the permeation side of the flow path. First liquid feeding for allowing a liquid flowed in from the first distribution port to flow out from the second distribution port, and second liquid feeding for allowing a liquid flowed in from the second distribution port to flow out from the first distribution port are alternately performed. A liquid that has passed through the filtration membrane is discharged from the first discharge port while the first liquid feeding is performed, and a liquid that has passed through the filtration membrane is discharged from the second discharge port while the second liquid feeding is performed.

A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator. The hardware component comprises a pump for flowing the suspension of biological cells to the inlet of the separator and at least one flow control device associated with the first outlet and the second outlet of the separator for selectively opening and closing the outlets so as to permit one of the first type of cells and the second type of cells to flow out of the separator in accordance with a predetermined duty cycle equal to the ratio of a target flow rate of first type of cells through the first outlet to the predetermined inlet flow rate.

Water treatment apparatus, including: a ceramic filter; and a flow apparatus operable to pass water through the ceramic filter in a forward direction so as to filter the water, the flow apparatus also operable to pass water through the ceramic filter in a reverse direction so as to remove material from the ceramic filter, whereby material having been deposited by filtration of the water is removed.