A device for tangential flow filtration includes a filter unit having first and second fluid openings, a filter element and a permeate opening, a first flow connection to connect the first fluid opening to a reservoir, a second flow connection to connect the second fluid opening to the reservoir, a first centrifugal pump in the first flow connection to convey the fluid from the reservoir to the filter unit, a first controller to actuate the first centrifugal pump, the filter unit designed such that the fluid for tangential flow filtration is capable of flowing substantially parallel to the filter element, a second centrifugal pump in the second flow connection, with which a counter-pressure is capable of being generated at the second fluid opening, and a second controller to actuate the second centrifugal pump.

The present disclosure relates to tangential flow filters, membranes, and ultrafiltration membranes, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same. In an aspect, an alternating tangential flow system for continuous processing may include a feed line containing a fluid. A retentate line may be in fluid communication with the feed line. A first diaphragm may be at an inlet of the retentate line configured to pump fluid toward an outlet of the retentate line. A second diaphragm may be at the outlet of the retentate line configured to pump fluid toward the inlet of the retentate line. A membrane may be in fluid communication with the retentate line between the first diaphragm and the second diaphragm. A retentate pump may be at the retentate outlet configured to pump the fluid out of the retentate line.

A filtration unit for separating at least one analyte from a fluid sample. The filtration unit includes: an inlet configured to receive the fluid sample and an outlet configured to receive the at least one analyte; a fluid pathway providing fluid communication between the inlet and the outlet, where the fluid pathway has a longitudinal axis along which the fluid sample flows, in use; a filter located in the fluid pathway, where the filter includes at least one surface configured to allow the passage of the at least one analyte and the at least one surface is substantially transverse to the longitudinal axis of the fluid pathway; and an impeller located adjacent to the filter, where the impeller is configured to generate tangential fluid flow in the vicinity of the filter and wherein the impeller includes a rotatable shaft coupled to at least one blade having a rounded leading edge.

The present disclosure relates to tangential flow filters, membranes, and ultrafiltration membranes, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same. In an aspect, an alternating tangential flow system for continuous processing may include a feed line containing a fluid. A retentate line may be in fluid communication with the feed line. A first diaphragm may be at an inlet of the retentate line configured to pump fluid toward an outlet of the retentate line. A second diaphragm may be at the outlet of the retentate line configured to pump fluid toward the inlet of the retentate line. A membrane may be in fluid communication with the retentate line between the first diaphragm and the second diaphragm. A retentate pump may be at the retentate outlet configured to pump the fluid out of the retentate line.

An oxygenator module for gas exchange between blood and a gas in an extracorporeal lung support system, with several layers of semipermeable, gas-perfusable hollow fibers, wherein the hollow fibers of one of the layers are oriented at an angle of rotation about a central longitudinal axis of the oxygenator module with respect to the hollow fibers of another one of the layers, and with a potting which extends along the central longitudinal axis and in which the hollow fibers are fixed, wherein the potting defines a cavity that extends along the central longitudinal axis and in which the hollow fibers are arranged and which is blood-perfusable in the direction of the central longitudinal axis, wherein the potting has an essentially circular inner sheath surface that limits the cavity radially outward; as well as a method for producing the oxygenator module.

A tangential filtration device, particularly for fluid food products, includes a tangential filter arranged essentially vertically and provided with a plurality of filtering membranes having a longitudinal extension and arranged essentially vertically, an inlet for the product to be filtered, an outlet for the retentate and an outlet for the permeate. The inlet for the product to be filtered is disposed at the lower portion of the tangential filter so that the filtering membranes are longitudinally crossed, from the bottom upwards, by the product to be processed. The device further includes a pump, a cleaning apparatus, and a collection area.

An orifice cavitation device is disclosed herein which promote cavitation at low operating pressures. An output opening has a sharp edge which facilitates cavitation. Moreover, an inner perimeter length may be increased by forming notches in the opening. Also, grooves may be formed on the inner surface of a funnel of the orifice cavitation device. The grooves may be straight and also spiral or slanted to encourage the water to rotate and increase shearing forces which also facilitates cavitation.