There is provided a multi-layered membrane for separating components in an aqueous sample. There is also provided a method of preparing said multi-layered membrane, a method of separating blood plasma from a whole blood sample and a diagnostic device for separation of blood plasma from a whole blood sample.

The invention relates to a blood treatment device configured to dephosphorylate extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and/or lipopolysaccharide (LPS) in the blood of a patient in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix having alkaline phosphatase (AP) immobilized thereon. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating an infection, preferably a blood or systemic infection, such as sepsis, and/or for the treatment of sepsis-associated acute kidney injury (AKI).

The invention relates to a method for preparing a MeAPO-18 supported membrane comprising a MeAPO-18 crystal layer on a porous support, wherein the obtained MeAPO-18 supported membrane as a lamellar crystal morphology. The invention is also directed to the said membranes and to their use.

The present specification relates to a method for manufacturing a water-treatment membrane, a water-treatment membrane manufactured using the same, and a water-treatment module including the water-treatment membrane.

The present specification relates to a method for manufacturing a water-treatment membrane, a water-treatment membrane manufactured using the same, and a water-treatment module including the water-treatment membrane.

The invention relates to a blood treatment device configured to dephosphorylate extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and/or lipopolysaccharide (LPS) in the blood of a patient in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix having alkaline phosphatase (AP) immobilized thereon. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating an infection, preferably a blood or systemic infection, such as sepsis, and/or for the treatment of sepsis-associated acute kidney injury (AKI).

The invention relates to a blood treatment device configured to dephosphorylate extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and/or lipopolysaccharide (LPS) in the blood of a patient in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix having alkaline phosphatase (AP) immobilized thereon. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating an infection, preferably a blood or systemic infection, such as sepsis, and/or for the treatment of sepsis-associated acute kidney injury (AKI).

A membrane made of a polymeric support, and an active layer with a polyamide grafted with a copolymer on the polymeric support. The copolymer is reacted units of a diallyldimethylammonium chloride (DADMAC), 3-(N,N-diallyl-N-methylammonio)propanesulfonate (DAMAPS), and N,N-diallyldodecane-1,12-diamine (DADA), and the copolymer is grafted to the polyamide with a linking molecule. Further, a method of making the membrane by dissolving an amine and the copolymer in water to form an aqueous solution, dissolving TMC in an organic solvent to form an organic mixture, pouring the aqueous solution onto a polymeric support and then pouring the organic mixture onto the same support for form a coated support, and heating the coated support to form a membrane.