The present invention aims to provide a porous separation membrane that does not suffer a significant decrease in the protein permeability even after long term use. The porous separation membrane has an asymmetric structure with a dense layer forming one surface layer and with a coarse layer forming the other surface layer, supports a biocompatible polymer, and meet the requirements (1) and (2) given below in surface analysis of a cross section containing the dense layer and the coarse layer performed by TOF-SIMS: (1) the minimum value of normalized intensity of the ion signal attributed to the biocompatible polymer in the coarse layer is 0.15 times or more of the maximum value, and (2) the normalized average intensity of the ion signal attributed to the biocompatible polymer in the dense layer is 2.0 times or more of the normalized average intensity of the ion signal attributed to carboxylic acid in the coarse layer.

This invention is directed to filtration system, filtration apparatus and methods of use thereof, wherein the filtration system comprises a solid support, perylene diimide based membrane layer and a polymer, specifically a Nafion polymer. The system and apparatus of this invention enables filtration of solutes such as: dyes, salts, heavy metal ions, pharmaceuticals and small organic molecules.

A method of manufacture of crosslinked, edible, porous hollow fibers and sheet membranes suitable for the manufacture of clean meat products, the hollow fibers and sheet membranes made therefrom and methods of use thereof.

Disclosed is an alumina membrane, its preparation method and application. The preparation method comprises the following steps: carrying out constant voltage anodizing treatment on a surface on one side of an aluminum sheet to obtain an alumina membrane with a porous structure on the surface on one side; removing pure aluminum on an other side of the alumina membrane by a physical processing method, and carrying out pore-enlarging treatment to obtain a membrane with interconnected pores on both sides; and depositing a silicon coating on the surface of the membrane on the side that has been physically processed to obtain the alumina membrane. According to the disclosure, the pure aluminum on the other side is etched by physical processing method after the aluminum on one side is oxidized, so as to avoid an absorbability of an alumina crystal form formed by chemical reagent corrosion on a platelet membrane protein.

The disclosure relates to a method for improving the selectivity of a membrane, specifically of a membrane comprising a blend of i) a polysulfone, polyethersulfone or polyarylethersulfone and ii) polyvinylpyrrolidone, characterized in that the membrane is coated with polydopamine and heparin in a one-step or two-step reaction or by in situ modification with polydopamine followed by coating with heparin. The disclosure further relates to a process for producing such modified membranes having an improved selectivity, and to a filtration/diffusion device comprising the membrane which can be used, for example, in hemodialysis applications.

The present disclosure relates to a membrane prepared from a blend comprising i) a polysulfone, polyether sulf one or polyarylethersulfone and ii) polyvinylpyrrolidone, characterized in that the membrane is coated with polydopamine and chon-droitin. Optionally the coating further comprises heparin. The disclosure further relates to a process for producing the coated membrane, a method of increasing the selectivity of a membrane, and to a filtration/diffusion device comprising the membrane which can be used, for example, in hemodialysis applications.

The present invention relates to a biocompatible membrane, specifically to a minimally swellable biocompatible membrane and the preparation method thereof. The preparation method of the minimally swellable biocompatible membrane comprises the following steps: synthesis of a copolymer containing a skeleton and a hydrophilic group, the introduction of a biocompatible property, the preparation of a biocompatible membrane solution, and the coating of the biocompatible membrane. The present invention can effectively regulate glucose, and has high biocompatibility (long service life) as well, thereby improving the sensitivity, accuracy, reproducibility, stability, specificity and anti-interference ability in a continuous glucose monitoring (CGM) system, prolonging the life time of the CGM, and greatly reducing the cost of the CGM.

The present invention aims to provide a porous separation membrane that does not suffer a significant decrease in the protein permeability even after long term use. The porous separation membrane has an asymmetric structure with a dense layer forming one surface layer and with a coarse layer forming the other surface layer, supports a biocompatible polymer, and meet the requirements (1) and (2) given below in surface analysis of a cross section containing the dense layer and the coarse layer performed by TOF-SIMS: (1) the minimum value of normalized intensity of the ion signal attributed to the biocompatible polymer in the coarse layer is 0.15 times or more of the maximum value, and (2) the normalized average intensity of the ion signal attributed to the biocompatible polymer in the dense layer is 2.0 times or more of the normalized average intensity of the ion signal attributed to carboxylic acid in the coarse layer.